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Study · Animal study (in vivo) · mouse

5 results

302 Abaloparatide as a novel therapy for posttraumatic osteoarthritis

Landgrave S, Ishii T, Maynard R, Wu A, Godfrey D, Manes T, Butler V, Villani D, Hendesi H, Frank R, Iyer S, Payne K and 4 more

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Adams D, Favazzo L, Lanske B, Zuscik M

Journal of clinical and translational science4 Jul 2022

PMCIDPMC9209282 (opens in a new tab)PepBankPUB-99761827
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with DMM injury, abaloparatide decreased cartilage loss versus saline.

    In plain wordsIn mice with knee injury, abaloparatide reduced cartilage loss versus saline.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    DecreaseCartilage loss
    Study

    mousen: not reported in source

    DMM-induced posttraumatic osteoarthritis
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg daily · subcutaneous · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    RESULTS/ANTICIPATED RESULTS: Safranin O/Fast Green stained sections showed a decreased cartilage loss in DMM joints from ABL-treated versus saline-treated mice.
    2 context sentences
    Summary · context
    METHODS/STUDY POPULATION: 16-week-old C57BL/6 male mice received destabilization of the medial meniscus (DMM) surgery to induce knee PTOA.
    Summary · context
    Beginning 2 weeks post-DMM, 40 μg/kg of ABL (or saline) was administered daily via subcutaneous injection and tissues were harvested after 6 weeks of daily injections and 8 weeks after DMM surgery.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with DMM injury, histomorphometry showed preservation of tibial cartilage tissue with abaloparatide.

    In plain wordsIn mice with knee injury, abaloparatide preserved tibial cartilage tissue versus saline.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseTibial cartilage area
    Study

    mousen: not reported in source

    DMM-induced posttraumatic osteoarthritis
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg daily · subcutaneous · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Histomorphometric analysis of total tibial cartilage area revealed preservation of cartilage tissue on the tibial surface.
    2 context sentences
    Summary · context
    METHODS/STUDY POPULATION: 16-week-old C57BL/6 male mice received destabilization of the medial meniscus (DMM) surgery to induce knee PTOA.
    Summary · context
    Beginning 2 weeks post-DMM, 40 μg/kg of ABL (or saline) was administered daily via subcutaneous injection and tissues were harvested after 6 weeks of daily injections and 8 weeks after DMM surgery.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with DMM injury, abaloparatide mitigated cartilage Col10 upregulation.

    In plain wordsIn mice with knee injury, abaloparatide reduced cartilage Col10 upregulation versus saline.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    DecreaseCol10 expression
    Study

    mousen: not reported in source

    DMM-induced posttraumatic osteoarthritis
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg daily · subcutaneous · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Immunohistochemical analyses showed that upregulation of Col10 in DMM joints was mitigated in the cartilage of ABL-treated mice, and chondrocyte expression of Prg4 was increased in uncalcified cartilage areas in ABL-treated group.
    2 context sentences
    Summary · context
    METHODS/STUDY POPULATION: 16-week-old C57BL/6 male mice received destabilization of the medial meniscus (DMM) surgery to induce knee PTOA.
    Summary · context
    Beginning 2 weeks post-DMM, 40 μg/kg of ABL (or saline) was administered daily via subcutaneous injection and tissues were harvested after 6 weeks of daily injections and 8 weeks after DMM surgery.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with DMM injury, abaloparatide increased chondrocyte Prg4 expression in uncalcified cartilage.

    In plain wordsIn mice with knee injury, abaloparatide increased cartilage cell Prg4 expression versus saline.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreasePrg4 expression
    Study

    mousen: not reported in source

    DMM-induced posttraumatic osteoarthritis
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg daily · subcutaneous · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Immunohistochemical analyses showed that upregulation of Col10 in DMM joints was mitigated in the cartilage of ABL-treated mice, and chondrocyte expression of Prg4 was increased in uncalcified cartilage areas in ABL-treated group.
    2 context sentences
    Summary · context
    METHODS/STUDY POPULATION: 16-week-old C57BL/6 male mice received destabilization of the medial meniscus (DMM) surgery to induce knee PTOA.
    Summary · context
    Beginning 2 weeks post-DMM, 40 μg/kg of ABL (or saline) was administered daily via subcutaneous injection and tissues were harvested after 6 weeks of daily injections and 8 weeks after DMM surgery.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with DMM injury, abaloparatide reduced larger hypertrophic-like cells in tibial cartilage.

    In plain wordsIn mice with knee injury, abaloparatide reduced enlarged cartilage cells versus saline.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    DecreaseLarge hypertrophic-like chondrocytes
    Study

    mousen: not reported in source

    DMM-induced posttraumatic osteoarthritis
    Comparator
    Saline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg daily · subcutaneous · 6 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Quantification of chondrocytes in uncalcified and calcified tibial cartilage areas revealed a reduction in the number of larger hypertrophic-like cells in ABL treated mice, suggesting deceleration of hypertrophic differentiation.
    2 context sentences
    Summary · context
    METHODS/STUDY POPULATION: 16-week-old C57BL/6 male mice received destabilization of the medial meniscus (DMM) surgery to induce knee PTOA.
    Summary · context
    Beginning 2 weeks post-DMM, 40 μg/kg of ABL (or saline) was administered daily via subcutaneous injection and tissues were harvested after 6 weeks of daily injections and 8 weeks after DMM surgery.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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