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Study · In vitro (cells) · 2018

5 results

Mechano growth factor E peptide inhibits invasion of melanoma cells and up-regulates CHOP expression via endoplasmic reticulum stress

He J, Dong L, Xu K, Qian Y, Wang C, Sha Y, Zhong J, Liu W, Lv Y, Song Y, Yang L

Biotechnology letters1 Jan 2018

PepBankPUB-98914263
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Summary

The text of this summary is not shown here, because the article license does not allow reuse.

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In GLL19 melanoma cells, MGF decreased the invasive capability measured by transwell assay.

    In plain wordsIn cells, MGF reduced how well melanoma cells invaded.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMelanoma cell invasion
    Study

    n: not reported in source

    GLL19 melanoma cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10, 20 and 30 ng/ml · 24 hAs given in this study.

    Source sentences

    Summary
    MGF decreased the invasive capabilities of melanoma cells
    1 context sentence
    Summary · context
    Melanoma cells (GLL19) were treated with 10, 20 and 30 ng MGF/ml for 24 h.
  2. 02LabIn vitro (cells)Mechanism

    In GLL19 melanoma cells, MGF induced changes in cytoskeleton distribution.

    In plain wordsIn cells, MGF changed how the internal cell scaffold was arranged in melanoma cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableCytoskeleton distribution
    Study

    n: not reported in source

    GLL19 melanoma cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10, 20 and 30 ng/ml · 24 hAs given in this study.

    Source sentences

    Summary
    induced changes in cytoskeleton distribution.
    1 context sentence
    Summary · context
    Melanoma cells (GLL19) were treated with 10, 20 and 30 ng MGF/ml for 24 h.
  3. 03LabIn vitro (cells)Mechanism

    In GLL19 melanoma cells, MGF down-regulated the expression of matrix metalloproteinases.

    In plain wordsIn cells, MGF lowered the level of enzymes that help melanoma cells invade.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMMP expression
    Study

    n: not reported in source

    GLL19 melanoma cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10, 20 and 30 ng/ml · 24 hAs given in this study.

    Source sentences

    Summary
    MGF also down-regulated the expression of MMPs
    1 context sentence
    Summary · context
    Melanoma cells (GLL19) were treated with 10, 20 and 30 ng MGF/ml for 24 h.
  4. 04LabIn vitro (cells)Mechanism

    In GLL19 melanoma cells, MGF up-regulated the apoptosis-related protein CHOP.

    In plain wordsIn cells, MGF raised the level of a cell death related protein in melanoma cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseCHOP expression
    Study

    n: not reported in source

    GLL19 melanoma cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10, 20 and 30 ng/ml · 24 hAs given in this study.

    Source sentences

    Summary
    up-regulated the expression of the cell apoptosis-related protein CHOP by inducing ER stress.
    1 context sentence
    Summary · context
    Melanoma cells (GLL19) were treated with 10, 20 and 30 ng MGF/ml for 24 h.
  5. 05LabIn vitro (cells)Mechanism

    In GLL19 melanoma cells, MGF induced endoplasmic reticulum stress.

    In plain wordsIn cells, MGF caused stress in a cell compartment called the endoplasmic reticulum.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseEndoplasmic reticulum stress
    Study

    n: not reported in source

    GLL19 melanoma cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10, 20 and 30 ng/ml · 24 hAs given in this study.

    Source sentences

    Summary
    by inducing ER stress.
    1 context sentence
    Summary · context
    Melanoma cells (GLL19) were treated with 10, 20 and 30 ng MGF/ml for 24 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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