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Study · Animal study (in vivo) · 2007

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Thymalfasin can potentiate immune-mediated killing of glioblastoma cells when used as an adjuvant in combination with a chloroethylnitrosurea chemotherapeutic compound

WANDS JACK R, LA MONTE SUZANNE

Journal not recorded10 Dec 2002

PepBankPUB-97040198
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In an in vivo glioblastoma model, thymalfasin added to BCNU enhanced BCNU-mediated eradication of glioblastoma compared with BCNU alone.

    In plain wordsIn an animal glioblastoma model, adding thymalfasin made the BCNU chemotherapy work better than BCNU alone.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseGlioblastoma eradication with BCNU
    Study

    n: not reported in source

    Comparator
    BCNU alone
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymalfasin enhances chloroehtylnitrosurea-mediated eradication of glioblastoma in vivo, and that thymalfasin mediates its effects by activating pro-apoptosis mechanisms, rendering neoplastic cells more sensitive to oxidative stress and killing by Granzyme B (T cells) or chemotherapy.
    1 context sentence
    Summary · context
    The figure shows the effect of BCNU and BCNU + thymalfasin (THY) on glioblastoma progression in vivo.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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