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Study · Not a test of the peptide alone · 2001

2 results

Expression and biological activities of thymosin alpha1-thioredoxin fusion protein

Zhao Yongtong, Shi Jihong, Zhao Ning, Wang Junlou, Yan Zhen, Han Wei, Zhang Yingqi

Pharmaceutical Biotechnology1 Jan 2001

PepBankPUB-96946437
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Summary

The text of this summary is not shown here, because the article license does not allow reuse.

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 01LabNot a test of Thymosin alpha-1 aloneEx vivo tissueActivity measurement

    In ConA-stimulated mouse spleen lymphocytes, the thioredoxin-thymosin alpha‑1 fusion protein increased the proliferative response.

    In plain wordsIn lab tests on mouse cells, a thymosin alpha‑1 fusion protein increased immune cell growth.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseProliferation of ConA-stimulated spleen lymphocytes
    Study

    mousen: not reported in source

    ConA-stimulated spleen lymphocytes
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The results showed that the fusion protein could increase the porliferative response of the mitogen ConA stimulated mice speen lymphocytes.
    1 context sentence
    Summary · context
    Its biological activity was analysed by ~(3)H-TdR incorparation.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 02LabNot a test of Thymosin alpha-1 aloneOther designOther

    In E. coli TOP10, a thioredoxin-thymosin alpha‑1 fusion protein of about 38 kD made up about 40% of total bacterial protein after IPTG induction.

    In plain wordsIn lab-grown bacteria, a thymosin alpha‑1 fusion protein made up about 40% of the bacterial protein.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableFusion protein expression level in E. coli
    Study

    n: not reported in source

    E. coli TOP10 expression system
    Outcome group
    Synthesis and manufacturing · Pharmacology

    Measurements

    Expression level
    ≈ 40 % of total bacterial protein
    E. coli TOP10, 1 mmol/L IPTG, 4 h
    Molecular weight
    ≈ 38 kD
    fusion protein

    Source sentences

    Summary
    By 12% SDS-PAGE and densitometry analysis, higher levels of expression of fusion protein, with a molecular weight of about 38 kD, was about 40% of the total bacteria protein after induction at 37deg C by 1 mmol/L IPTG for 4 hours, and was identified by western blotting.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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