Anti-nervous necrosis virus activity of the growth hormone releasing peptide-6, GHRP-6

Álvarez-Torres D, Martínez R, Moreno P, Alonso MC, García-Rosado E, Estrada MP, Béjar J

Aquaculture international : journal of the European Aquaculture Society1 Jun 2025

PepBankPUB-96408221

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Summary

The text of this summary is not shown here, because the article license does not allow reuse.

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In European seabass, GHRP‑6 significantly increased TNF-A expression in head kidney and intestine.
In plain wordsIn European seabass, GHRP‑6 increased TNF-A gene expression in head kidney and intestine.
Peptide
GHRP-6
Outcome
IncreaseTNF-A expression
Study
European seabassn: not reported in source
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · intraperitonealAs given in this study (European seabass).
Source sentences
Summary
In order to conduct the in vivo evaluation, European seabass specimens were intraperitoneally injected with GHRP-6, resulting in the significant upregulation of several immune genes, such as TNF-A, RTP3, and IgM, in head kidney and intestine.
1 context sentence(design, population, supporting numbers)
Summary · context
This study evaluates the effects of GHRP-6 against the infection with the nervous necrosis virus (NNV), an important pathogen affecting the central nervous system of a wide range of fish species, including European seabass (Dicentrarchus labrax).
Report a problemFND-9640822104
02AnimalAnimal study (in vivo)Mechanism
In European seabass, GHRP‑6 significantly increased RTP3 expression in head kidney and intestine.
In plain wordsIn European seabass, GHRP‑6 increased RTP3 gene expression in head kidney and intestine.
Peptide
GHRP-6
Outcome
IncreaseRTP3 expression
Study
European seabassn: not reported in source
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · intraperitonealAs given in this study (European seabass).
Source sentences
Summary
In order to conduct the in vivo evaluation, European seabass specimens were intraperitoneally injected with GHRP-6, resulting in the significant upregulation of several immune genes, such as TNF-A, RTP3, and IgM, in head kidney and intestine.
1 context sentence(design, population, supporting numbers)
Summary · context
This study evaluates the effects of GHRP-6 against the infection with the nervous necrosis virus (NNV), an important pathogen affecting the central nervous system of a wide range of fish species, including European seabass (Dicentrarchus labrax).
Report a problemFND-9640822105
03AnimalAnimal study (in vivo)Mechanism
In European seabass, GHRP‑6 significantly increased IgM expression in head kidney and intestine.
In plain wordsIn European seabass, GHRP‑6 increased IgM gene expression in head kidney and intestine.
Peptide
GHRP-6
Outcome
IncreaseIgM expression
Study
European seabassn: not reported in source
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · intraperitonealAs given in this study (European seabass).
Source sentences
Summary
In order to conduct the in vivo evaluation, European seabass specimens were intraperitoneally injected with GHRP-6, resulting in the significant upregulation of several immune genes, such as TNF-A, RTP3, and IgM, in head kidney and intestine.
1 context sentence(design, population, supporting numbers)
Summary · context
This study evaluates the effects of GHRP-6 against the infection with the nervous necrosis virus (NNV), an important pathogen affecting the central nervous system of a wide range of fish species, including European seabass (Dicentrarchus labrax).
Report a problemFND-9640822106
04AnimalAnimal study (in vivo)Efficacy outcome
In European seabass, brain NNV replication was lower with GHRP‑6 than in controls.
In plain wordsIn European seabass, GHRP‑6 reduced brain viral replication compared with controls.
Peptide
GHRP-6
Outcome
DecreaseBrain NNV replication
Study
European seabassn: not reported in source
Comparator
Controls
Outcome group
Antiviral activity · Infection
Studied dose
Dose not stated · intraperitonealAs given in this study (European seabass).
Source sentences
Summary
Furthermore, NNV replication was lower in the brain from GHRP-6 injected fish than in controls, and the brain antiviral immune response was clearly modulated in treated fish.
1 context sentence(design, population, supporting numbers)
Summary · context
This study evaluates the effects of GHRP-6 against the infection with the nervous necrosis virus (NNV), an important pathogen affecting the central nervous system of a wide range of fish species, including European seabass (Dicentrarchus labrax).
Report a problemFND-9640822107
05AnimalAnimal study (in vivo)Mechanism
In European seabass, GHRP‑6 modulated the brain antiviral immune response.
In plain wordsIn European seabass, GHRP‑6 changed the brain antiviral immune response, with no direction stated.
Peptide
GHRP-6
Outcome
Direction not reportedBrain antiviral immune response
Study
European seabassn: not reported in source
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · intraperitonealAs given in this study (European seabass).
Source sentences
Summary
Furthermore, NNV replication was lower in the brain from GHRP-6 injected fish than in controls, and the brain antiviral immune response was clearly modulated in treated fish.
1 context sentence(design, population, supporting numbers)
Summary · context
This study evaluates the effects of GHRP-6 against the infection with the nervous necrosis virus (NNV), an important pathogen affecting the central nervous system of a wide range of fish species, including European seabass (Dicentrarchus labrax).
Report a problemFND-9640822108
06LabIn vitro (cells)Efficacy outcome
In E11 cells, GHRP‑6 increased cellular survival during NNV infection compared with control cells.
In plain wordsIn cells, GHRP‑6 increased survival during viral infection compared with control cells.
Peptide
GHRP-6
Outcome
IncreaseCellular survival
Study
n: not reported in source
E11 cells
Comparator
Control cells
Outcome group
Antiviral activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
For the in vitro evaluation, E11 cells were treated with GHRP-6 before and/or during viral infection, resulting in higher cellular survival rates, lower viral genome replication, and lower production of infective viral particles compared with control cells.
1 context sentence(design, population, supporting numbers)
Summary · context
This study evaluates the effects of GHRP-6 against the infection with the nervous necrosis virus (NNV), an important pathogen affecting the central nervous system of a wide range of fish species, including European seabass (Dicentrarchus labrax).
Report a problemFND-9640822101
07LabIn vitro (cells)Efficacy outcome
In E11 cells, GHRP‑6 reduced NNV genome replication compared with control cells.
In plain wordsIn cells, GHRP‑6 reduced viral genome replication compared with control cells.
Peptide
GHRP-6
Outcome
DecreaseViral genome replication
Study
n: not reported in source
E11 cells
Comparator
Control cells
Outcome group
Antiviral activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
For the in vitro evaluation, E11 cells were treated with GHRP-6 before and/or during viral infection, resulting in higher cellular survival rates, lower viral genome replication, and lower production of infective viral particles compared with control cells.
1 context sentence(design, population, supporting numbers)
Summary · context
This study evaluates the effects of GHRP-6 against the infection with the nervous necrosis virus (NNV), an important pathogen affecting the central nervous system of a wide range of fish species, including European seabass (Dicentrarchus labrax).
Report a problemFND-9640822102
08LabIn vitro (cells)Efficacy outcome
In E11 cells, GHRP‑6 reduced production of infective NNV particles compared with control cells.
In plain wordsIn cells, GHRP‑6 reduced production of infectious viral particles compared with control cells.
Peptide
GHRP-6
Outcome
DecreaseInfective viral particle production
Study
n: not reported in source
E11 cells
Comparator
Control cells
Outcome group
Antiviral activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
For the in vitro evaluation, E11 cells were treated with GHRP-6 before and/or during viral infection, resulting in higher cellular survival rates, lower viral genome replication, and lower production of infective viral particles compared with control cells.
1 context sentence(design, population, supporting numbers)
Summary · context
This study evaluates the effects of GHRP-6 against the infection with the nervous necrosis virus (NNV), an important pathogen affecting the central nervous system of a wide range of fish species, including European seabass (Dicentrarchus labrax).
Report a problemFND-9640822103

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

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