A comparison of changes in whole body and skin amino acid metabolism of sheep in response to 24 h continuous infusions of variants of insulin-like growth factor 1

Lobley GE, Lee J, Hocking Edwards J, Harris PM

Canadian Journal of Animal Science1 Dec 1997Cited by 2 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In sheep, plasma immunoreactive IGF-1 decreased after 24 h of LR3IGF-1 infusion, while it increased with rhIGF-1.
In plain wordsIn sheep, blood IGF-1 fell after 24 hours of LR3IGF-1, while it rose with rhIGF-1.
Peptide
IGF-1 LR3
Outcome
DecreasePlasma immunoreactive IGF-1 after 24 h
Study
sheepn = 3
adult castrated Romney sheep
Comparator
rhIGF-1
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · close-arterial skin infusion · 24 hAs given in this study (sheep).
Source sentences
Summary
The plasma concentration of immunoreactive IGF-1 of sheep infused with rhIGF-1 increased (P < 0.01) with time of administration, but decreased (P < 0.05) after 24 h of LR3IGF-1 infusion.
1 context sentence(design, population, supporting numbers)
Summary · context
comparing the effects of a 24 h, close-arterial, skin infusion of IGF-1, in the form of either recombinant human (rhIGF-1) or an extended variant (LR3IGF-1), on both whole body and skin amino acid metabolism adult, castrated Romney sheep, with three animals allocated to each treatment
Report a problemFND-9524318701
02AnimalAnimal study (in vivo)Mechanism
In sheep, both IGF-1 variants, including LR3IGF-1, caused a sustained decrease in arterial insulin to less than 50% of pre-infusion values.
In plain wordsIn sheep, both IGF-1 forms, including LR3IGF-1, cut blood insulin to less than half of its starting value.
Peptide
IGF-1 LR3
Outcome
DecreaseArterial insulin
Study
sheepn = 3
adult castrated Romney sheep
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
Dose not stated · close-arterial skin infusion · 24 hAs given in this study (sheep).
Source sentences
Summary
Administration of both IGF-1 variants caused a substantial and sustained decrease in arterial insulin to less than 50% (P < 0.05) of pre-infusion values
1 context sentence(design, population, supporting numbers)
Summary · context
comparing the effects of a 24 h, close-arterial, skin infusion of IGF-1, in the form of either recombinant human (rhIGF-1) or an extended variant (LR3IGF-1), on both whole body and skin amino acid metabolism adult, castrated Romney sheep, with three animals allocated to each treatment
Report a problemFND-9524318702
03AnimalAnimal study (in vivo)Mechanism
In sheep, both IGF-1 variants, including LR3IGF-1, reduced arterial plasma glucose by only 7%.
In plain wordsIn sheep, both IGF-1 forms, including LR3IGF-1, lowered blood glucose by only 7%.
Peptide
IGF-1 LR3
Outcome
DecreaseArterial plasma glucose
Study
sheepn = 3
adult castrated Romney sheep
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · close-arterial skin infusion · 24 hAs given in this study (sheep).
Measurements
Arterial plasma glucose reduction
7%
both IGF-1 variants
Source sentences
Summary
Administration of both IGF-1 variants caused a substantial and sustained decrease in arterial insulin to less than 50% (P < 0.05) of pre-infusion values, while arterial plasma glucose concentrations were only reduced by 7%.
1 context sentence(design, population, supporting numbers)
Summary · context
comparing the effects of a 24 h, close-arterial, skin infusion of IGF-1, in the form of either recombinant human (rhIGF-1) or an extended variant (LR3IGF-1), on both whole body and skin amino acid metabolism adult, castrated Romney sheep, with three animals allocated to each treatment
Report a problemFND-9524318703
04AnimalAnimal study (in vivo)Mechanism
In sheep, IGF-1 infusions, including LR3IGF-1, decreased amino acid concentrations within 4 h.
In plain wordsIn sheep, IGF-1 infusions, including LR3IGF-1, lowered amino acid levels in blood within 4 hours.
Peptide
IGF-1 LR3
Outcome
DecreasePlasma amino acid concentrations
Study
sheepn = 3
adult castrated Romney sheep
Outcome group
Protein and amino acid metabolism · Metabolic and weight
Studied dose
Dose not stated · close-arterial skin infusion · 24 hAs given in this study (sheep).
Source sentences
Summary
Within 4 h both AA concentrations and whole body plasma ILR of essential and non-essential AA were decreased (P < 0.05 for seven AA) by IGF-1 infusions.
1 context sentence(design, population, supporting numbers)
Summary · context
comparing the effects of a 24 h, close-arterial, skin infusion of IGF-1, in the form of either recombinant human (rhIGF-1) or an extended variant (LR3IGF-1), on both whole body and skin amino acid metabolism adult, castrated Romney sheep, with three animals allocated to each treatment
Report a problemFND-9524318704
05AnimalAnimal study (in vivo)Mechanism
In sheep, IGF-1 infusions, including LR3IGF-1, decreased whole body plasma ILR of essential and non-essential amino acids within 4 h.
In plain wordsIn sheep, IGF-1 infusions, including LR3IGF-1, lowered whole-body amino acid turnover measures within 4 hours.
Peptide
IGF-1 LR3
Outcome
DecreaseWhole body plasma ILR of amino acids
Study
sheepn = 3
adult castrated Romney sheep
Outcome group
Protein and amino acid metabolism · Metabolic and weight
Studied dose
Dose not stated · close-arterial skin infusion · 24 hAs given in this study (sheep).
Source sentences
Summary
Within 4 h both AA concentrations and whole body plasma ILR of essential and non-essential AA were decreased (P < 0.05 for seven AA) by IGF-1 infusions.
1 context sentence(design, population, supporting numbers)
Summary · context
comparing the effects of a 24 h, close-arterial, skin infusion of IGF-1, in the form of either recombinant human (rhIGF-1) or an extended variant (LR3IGF-1), on both whole body and skin amino acid metabolism adult, castrated Romney sheep, with three animals allocated to each treatment
Report a problemFND-9524318705
06AnimalAnimal study (in vivo)Mechanism
In sheep, both IGF-1 variants, including LR3IGF-1, caused acute increases in skin blood flow.
In plain wordsIn sheep, both IGF-1 forms, including LR3IGF-1, quickly raised blood flow in the skin.
Peptide
IGF-1 LR3
Outcome
IncreaseSkin blood flow, acute
Study
sheepn = 3
adult castrated Romney sheep
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · close-arterial skin infusion · 24 hAs given in this study (sheep).
Source sentences
Summary
Both IGF-1 variants caused acute increases (P < 0.05) in skin blood flow and, for 13 of the 15 AA measured, isotopic transfers (range 50-220%; P < 0.05 for cysteine and tyrosine), which probably reflect increased protein synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
comparing the effects of a 24 h, close-arterial, skin infusion of IGF-1, in the form of either recombinant human (rhIGF-1) or an extended variant (LR3IGF-1), on both whole body and skin amino acid metabolism adult, castrated Romney sheep, with three animals allocated to each treatment
Report a problemFND-9524318706
07AnimalAnimal study (in vivo)Mechanism
In sheep, both IGF-1 variants, including LR3IGF-1, acutely increased isotopic transfers for 13 of 15 amino acids in skin, which probably reflects increased protein synthesis.
In plain wordsIn sheep, both IGF-1 forms, including LR3IGF-1, quickly raised amino acid transfers in skin, probably reflecting more protein synthesis.
Peptide
IGF-1 LR3
Outcome
IncreaseSkin amino acid isotopic transfers
Study
sheepn = 3
adult castrated Romney sheep
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · close-arterial skin infusion · 24 hAs given in this study (sheep).
Measurements
Isotopic transfer increase
50 to 220%
13 of 15 amino acids
Source sentences
Summary
Both IGF-1 variants caused acute increases (P < 0.05) in skin blood flow and, for 13 of the 15 AA measured, isotopic transfers (range 50-220%; P < 0.05 for cysteine and tyrosine), which probably reflect increased protein synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
comparing the effects of a 24 h, close-arterial, skin infusion of IGF-1, in the form of either recombinant human (rhIGF-1) or an extended variant (LR3IGF-1), on both whole body and skin amino acid metabolism adult, castrated Romney sheep, with three animals allocated to each treatment
Report a problemFND-9524318707
08AnimalAnimal study (in vivo)Mechanism
In sheep, skin blood flow had returned to pre-infusion values by 24 h of IGF-1 infusion.
In plain wordsIn sheep, skin blood flow was back to its starting value by 24 hours of IGF-1 infusion.
Peptide
IGF-1 LR3
Outcome
No significant changeSkin blood flow at 24 h
Study
sheepn = 3
adult castrated Romney sheep
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · close-arterial skin infusion · 24 hAs given in this study (sheep).
Source sentences
Summary
By 24 h skin blood flow, AA uptake and protein synthesis had returned to pre-infusion values.
1 context sentence(design, population, supporting numbers)
Summary · context
comparing the effects of a 24 h, close-arterial, skin infusion of IGF-1, in the form of either recombinant human (rhIGF-1) or an extended variant (LR3IGF-1), on both whole body and skin amino acid metabolism adult, castrated Romney sheep, with three animals allocated to each treatment
Report a problemFND-9524318708
09AnimalAnimal study (in vivo)Mechanism
In sheep, skin amino acid uptake had returned to pre-infusion values by 24 h of IGF-1 infusion.
In plain wordsIn sheep, amino acid uptake in skin was back to its starting value by 24 hours of IGF-1 infusion.
Peptide
IGF-1 LR3
Outcome
No significant changeSkin amino acid uptake at 24 h
Study
sheepn = 3
adult castrated Romney sheep
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · close-arterial skin infusion · 24 hAs given in this study (sheep).
Source sentences
Summary
By 24 h skin blood flow, AA uptake and protein synthesis had returned to pre-infusion values.
1 context sentence(design, population, supporting numbers)
Summary · context
comparing the effects of a 24 h, close-arterial, skin infusion of IGF-1, in the form of either recombinant human (rhIGF-1) or an extended variant (LR3IGF-1), on both whole body and skin amino acid metabolism adult, castrated Romney sheep, with three animals allocated to each treatment
Report a problemFND-9524318709
10AnimalAnimal study (in vivo)Mechanism
In sheep, skin protein synthesis had returned to pre-infusion values by 24 h of IGF-1 infusion.
In plain wordsIn sheep, protein synthesis in skin was back to its starting value by 24 hours of IGF-1 infusion.
Peptide
IGF-1 LR3
Outcome
No significant changeSkin protein synthesis at 24 h
Study
sheepn = 3
adult castrated Romney sheep
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · close-arterial skin infusion · 24 hAs given in this study (sheep).
Source sentences
Summary
By 24 h skin blood flow, AA uptake and protein synthesis had returned to pre-infusion values.
1 context sentence(design, population, supporting numbers)
Summary · context
comparing the effects of a 24 h, close-arterial, skin infusion of IGF-1, in the form of either recombinant human (rhIGF-1) or an extended variant (LR3IGF-1), on both whole body and skin amino acid metabolism adult, castrated Romney sheep, with three animals allocated to each treatment
Report a problemFND-9524318710
11AnimalAnimal study (in vivo)Efficacy outcome
In sheep, food intake did not differ between the LR3IGF-1 and rhIGF-1 groups.
In plain wordsIn sheep, food intake was the same with LR3IGF-1 as with rhIGF-1.
Peptide
IGF-1 LR3
Outcome
No significant changeFood intake
Study
sheepn = 3
adult castrated Romney sheep
Comparator
rhIGF-1
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · close-arterial skin infusion · 24 hAs given in this study (sheep).
Source sentences
Summary
There were no differences in food intake between the two treatment groups.
1 context sentence(design, population, supporting numbers)
Summary · context
comparing the effects of a 24 h, close-arterial, skin infusion of IGF-1, in the form of either recombinant human (rhIGF-1) or an extended variant (LR3IGF-1), on both whole body and skin amino acid metabolism adult, castrated Romney sheep, with three animals allocated to each treatment
Report a problemFND-9524318711

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

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