Hypothalamic actions of growth hormone secretagogues

Kumarnsit E

University of Edinburgh1 Jan 2003

PepBankPUB-95096170

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In rat hypothalamic tissue, GHRP‑6 significantly increased arcuate neuron electrical activity.
In plain wordsIn lab tests, GHRP‑6 increased electrical activity in rat arcuate neurons.
Peptide
GHRP-6
Outcome
IncreaseArcuate neuron electrical activity
Study
ratn: not reported in source
Hypothalamic neurons in vitro
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Extracellular recordings showed that electrical activity of neuronal population in the arcuate nucleus was significantly excited by GHRP-6 and L-144,446.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, the rat hypothalamic brain areas; the arcuate nucleus and the ventromedial hypothalamic nucleus, were selected for study of GHRP-6 and L-144,446 effects in vitro.
Report a problemFND-9509617001
02LabEx vivo tissueActivity measurement
In rat hypothalamic tissue, GHRP‑6 and L-144,446 produced closely similar excitation patterns.
In plain wordsIn lab tests, GHRP‑6 and L-144,446 produced closely similar excitation patterns in rat hypothalamic neurons.
Peptide
GHRP-6
Outcome
Not applicableExcitation pattern versus L-144,446
Study
ratn: not reported in source
Hypothalamic neurons in vitro
Comparator
L-144,446
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Patterns of excitation by either GHRP-6 or L-144,446 were closely similar.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, the rat hypothalamic brain areas; the arcuate nucleus and the ventromedial hypothalamic nucleus, were selected for study of GHRP-6 and L-144,446 effects in vitro.
Report a problemFND-9509617002
03LabEx vivo tissueActivity measurement
In rat hypothalamic tissue, the secretagogue-induced firing increase had a latency of approximately 2 to 5 minutes.
In plain wordsIn lab tests, rat hypothalamic firing increased approximately 2 to 5 minutes after secretagogue exposure.
Peptide
GHRP-6
Outcome
Not applicableFiring response latency
Study
ratn: not reported in source
Hypothalamic neurons in vitro
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Measurements
Latency
2 to 5 min
secretagogue-induced firing
Source sentences
Summary
The increase in firing rate was observed with latency period of approximately 2 to 5 min.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, the rat hypothalamic brain areas; the arcuate nucleus and the ventromedial hypothalamic nucleus, were selected for study of GHRP-6 and L-144,446 effects in vitro.
Report a problemFND-9509617003
04LabEx vivo tissueActivity measurement
In rat hypothalamic tissue, excitation persisted more than 1 hour after secretagogue washout.
In plain wordsIn lab tests, rat hypothalamic excitation persisted more than 1 hour after the secretagogue was removed.
Peptide
GHRP-6
Outcome
Not applicableExcitation persistence
Study
ratn: not reported in source
Hypothalamic neurons in vitro
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The excitation was sustained for more than 1 h after the secretagogue washout.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, the rat hypothalamic brain areas; the arcuate nucleus and the ventromedial hypothalamic nucleus, were selected for study of GHRP-6 and L-144,446 effects in vitro.
Report a problemFND-9509617004
05LabEx vivo tissueActivity measurement
In rat hypothalamic tissue, GHRP‑6 increased ventromedial neuron firing.
In plain wordsIn lab tests, GHRP‑6 increased firing in rat ventromedial hypothalamic neurons.
Peptide
GHRP-6
Outcome
IncreaseVentromedial neuron firing
Study
ratn: not reported in source
Hypothalamic neurons in vitro
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Interestingly, GHRF-6 was also observed to increase the firing activity of neurones in the ventromedial hypothalamic nucleus.
2 context sentences(design, population, supporting numbers)
Summary · context
According to our evidence that ventromedial hypothalamic neurones were significantly excited to GHRP-6 in vitro, it was hypothesised that, in vivo, ... (continues)
Summary · context
In this study, the rat hypothalamic brain areas; the arcuate nucleus and the ventromedial hypothalamic nucleus, were selected for study of GHRP-6 and L-144,446 effects in vitro.
Report a problemFND-9509617005
06LabEx vivo tissueActivity measurement
In rat hypothalamic tissue, ventromedial firing responses to GHRP‑6 resembled arcuate neuron responses.
In plain wordsIn lab tests, rat ventromedial neurons showed GHRP‑6 firing responses similar to arcuate neurons.
Peptide
GHRP-6
Outcome
Not applicableRegional firing patterns
Study
ratn: not reported in source
Hypothalamic neurons in vitro
Comparator
Arcuate neurons
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Patterns of increase in firing activity of ventromedial hypothalamic neurones were very similar to those observed in arcuate neurones.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, the rat hypothalamic brain areas; the arcuate nucleus and the ventromedial hypothalamic nucleus, were selected for study of GHRP-6 and L-144,446 effects in vitro.
Report a problemFND-9509617006

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Dissertation

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