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Study · Animal study (in vivo) · rat · 2016

6 results

Intramuscular injection of mechano growth factor E domain peptide regulated expression of memory-related sod, miR-134 and miR-125b-3p in rat hippocampus under simulated weightlessness

Chen H, Lv K, Dai Z, Ji G, Wang T, Wang Y, Zhang Y, Kan G, Li Y, Qu L

Biotechnology letters1 Dec 2016

PepBankPUB-95083370
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Summary

The text of this summary is not shown here, because the article license does not allow reuse.

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats under simulated weightlessness, intramuscular MGF E domain peptide inhibited the rise in hippocampal Igf-iea mRNA.

    In plain wordsIn rats under simulated weightlessness, the MGF E domain peptide blocked a rise in brain Igf-iea gene activity.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseIgf-iea mRNA in hippocampus under simulated weightlessness
    Study

    ratn: not reported in source

    Hippocampus under simulated weightlessness (14 days tail suspension)
    Comparator
    Tail suspension without E domain peptide
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscularAs given in this study (rat).

    Source sentences

    Summary
    Igf-iea and mgf mRNA levels, expression of antioxidant genes sod1 and sod2 and levels of miR-134 and miR-125b-3p increased in rat hippocampus after 14 days tail suspension to simulate weightlessness which was inhibited with intramuscular injection of E domain peptide.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats under simulated weightlessness, intramuscular MGF E domain peptide inhibited the rise in hippocampal mgf mRNA.

    In plain wordsIn rats under simulated weightlessness, the MGF E domain peptide blocked a rise in brain mgf gene activity.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMgf mRNA in hippocampus under simulated weightlessness
    Study

    ratn: not reported in source

    Hippocampus under simulated weightlessness (14 days tail suspension)
    Comparator
    Tail suspension without E domain peptide
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscularAs given in this study (rat).

    Source sentences

    Summary
    Igf-iea and mgf mRNA levels, expression of antioxidant genes sod1 and sod2 and levels of miR-134 and miR-125b-3p increased in rat hippocampus after 14 days tail suspension to simulate weightlessness which was inhibited with intramuscular injection of E domain peptide.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats under simulated weightlessness, intramuscular MGF E domain peptide inhibited the rise in hippocampal sod1 expression.

    In plain wordsIn rats under simulated weightlessness, the MGF E domain peptide blocked a rise in brain sod1 gene activity.

    Peptide
    MGF / PEG-MGF
    Outcome
    Decreasesod1 expression in hippocampus under simulated weightlessness
    Study

    ratn: not reported in source

    Hippocampus under simulated weightlessness (14 days tail suspension)
    Comparator
    Tail suspension without E domain peptide
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscularAs given in this study (rat).

    Source sentences

    Summary
    Igf-iea and mgf mRNA levels, expression of antioxidant genes sod1 and sod2 and levels of miR-134 and miR-125b-3p increased in rat hippocampus after 14 days tail suspension to simulate weightlessness which was inhibited with intramuscular injection of E domain peptide.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats under simulated weightlessness, intramuscular MGF E domain peptide inhibited the rise in hippocampal sod2 expression.

    In plain wordsIn rats under simulated weightlessness, the MGF E domain peptide blocked a rise in brain sod2 gene activity.

    Peptide
    MGF / PEG-MGF
    Outcome
    Decreasesod2 expression in hippocampus under simulated weightlessness
    Study

    ratn: not reported in source

    Hippocampus under simulated weightlessness (14 days tail suspension)
    Comparator
    Tail suspension without E domain peptide
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscularAs given in this study (rat).

    Source sentences

    Summary
    Igf-iea and mgf mRNA levels, expression of antioxidant genes sod1 and sod2 and levels of miR-134 and miR-125b-3p increased in rat hippocampus after 14 days tail suspension to simulate weightlessness which was inhibited with intramuscular injection of E domain peptide.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats under simulated weightlessness, intramuscular MGF E domain peptide inhibited the rise in hippocampal miR-134.

    In plain wordsIn rats under simulated weightlessness, the MGF E domain peptide blocked a rise in brain miR-134.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreasemiR-134 level in hippocampus under simulated weightlessness
    Study

    ratn: not reported in source

    Hippocampus under simulated weightlessness (14 days tail suspension)
    Comparator
    Tail suspension without E domain peptide
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscularAs given in this study (rat).

    Source sentences

    Summary
    Igf-iea and mgf mRNA levels, expression of antioxidant genes sod1 and sod2 and levels of miR-134 and miR-125b-3p increased in rat hippocampus after 14 days tail suspension to simulate weightlessness which was inhibited with intramuscular injection of E domain peptide.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats under simulated weightlessness, intramuscular MGF E domain peptide inhibited the rise in hippocampal miR-125b-3p.

    In plain wordsIn rats under simulated weightlessness, the MGF E domain peptide blocked a rise in brain miR-125b-3p.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreasemiR-125b-3p level in hippocampus under simulated weightlessness
    Study

    ratn: not reported in source

    Hippocampus under simulated weightlessness (14 days tail suspension)
    Comparator
    Tail suspension without E domain peptide
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscularAs given in this study (rat).

    Source sentences

    Summary
    Igf-iea and mgf mRNA levels, expression of antioxidant genes sod1 and sod2 and levels of miR-134 and miR-125b-3p increased in rat hippocampus after 14 days tail suspension to simulate weightlessness which was inhibited with intramuscular injection of E domain peptide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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