SUN-311 Adrenal Reserve Testing with the Glucagon Stimulation Test (GST) and Cosyntropin Stimulation Test (CST) in Deployed Veterans with Mild Traumatic Brain Injury

Nagireddi R, Win H, Wagstaff S, Neal M, Friedman K, Anderson R

Journal of the Endocrine Society8 May 2020

PMCIDPMC7208304PepBankPUB-93112381

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cosyntropin.

01HumanNot a test of Cosyntropin aloneObservational studyActivity measurement
In veterans with mild traumatic brain injury, 60-minute cosyntropin cortisol correlated with glucagon-test cortisol at Year 0 (r=0.553, p=0.008).
In plain wordsIn veterans with mild brain injury, cosyntropin and glucagon cortisol tests correlated at baseline.
Peptide
Cosyntropin
Outcome
Not applicableCortisol test correlation at Year 0
Study
n = 22
Comparator
Glucagon stimulation test
Outcome group
Adrenal Diagnostic Testing · Endocrine and hormones
Measurements
Correlation, GST cortisol vs 60-minute CST cortisol, Year 0
0.553 r
n = 22; p = 0.008
Source sentences
Summary
Correlations of the cortisol levels from GST vs the 60-minute cortisol from CST were significant at Year 0 (n=22, r=0.553, p=0.008) and at Year 1 (n=18, r=0.802, p<0.0001).
2 context sentences(design, population, supporting numbers)
Summary · context
We reviewed the utility of the fixed dose Glucagon Stimulation Test (GST) compared with the high dose Cosyntropin Stimulation test (CST) for hypothalamic-pituitary-adrenal (HPA) reserve over time in these patients with mTBI.
Summary · context
We present an interim report of our 4-year longitudinal prospective pilot study of pituitary function in Veterans diagnosed with mTBI.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-9311238101
02HumanNot a test of Cosyntropin aloneObservational studyActivity measurement
In veterans with mild traumatic brain injury, 60-minute cosyntropin cortisol correlated with glucagon-test cortisol at Year 1 (r=0.802, p<0.0001).
In plain wordsIn veterans with mild brain injury, cosyntropin and glucagon cortisol tests correlated at the next annual test.
Peptide
Cosyntropin
Outcome
Not applicableCortisol test correlation at Year 1
Study
n = 18
Comparator
Glucagon stimulation test
Outcome group
Adrenal Diagnostic Testing · Endocrine and hormones
Measurements
Correlation, GST cortisol vs 60-minute CST cortisol, Year 1
0.802 r
n = 18; p < 0.0001
Source sentences
Summary
Correlations of the cortisol levels from GST vs the 60-minute cortisol from CST were significant at Year 0 (n=22, r=0.553, p=0.008) and at Year 1 (n=18, r=0.802, p<0.0001).
2 context sentences(design, population, supporting numbers)
Summary · context
We reviewed the utility of the fixed dose Glucagon Stimulation Test (GST) compared with the high dose Cosyntropin Stimulation test (CST) for hypothalamic-pituitary-adrenal (HPA) reserve over time in these patients with mTBI.
Summary · context
We present an interim report of our 4-year longitudinal prospective pilot study of pituitary function in Veterans diagnosed with mTBI.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-9311238102
03HumanNot a test of Cosyntropin aloneObservational studyActivity measurement
In veterans with mild traumatic brain injury, cosyntropin cortisol predicted low glucagon-test cortisol in only 2/6 subjects.
In plain wordsIn veterans with mild brain injury, cosyntropin testing predicted low glucagon-test cortisol in only 2/6 subjects.
Peptide
Cosyntropin
Outcome
Not applicablePrediction of low glucagon-test cortisol
Study
n = 6
Comparator
Glucagon stimulation test
Outcome group
Adrenal Diagnostic Testing · Endocrine and hormones
Measurements
Low GST cortisol cases predicted by CST cortisol
2 subjects
of 6 subjects
Source sentences
Summary
However, the CST cortisol value predicted the low GST value in only 2/6 subjects.
2 context sentences(design, population, supporting numbers)
Summary · context
We reviewed the utility of the fixed dose Glucagon Stimulation Test (GST) compared with the high dose Cosyntropin Stimulation test (CST) for hypothalamic-pituitary-adrenal (HPA) reserve over time in these patients with mTBI.
Summary · context
We present an interim report of our 4-year longitudinal prospective pilot study of pituitary function in Veterans diagnosed with mTBI.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-9311238105
04HumanNot a test of Cosyntropin aloneObservational studyActivity measurement
In veterans with mild traumatic brain injury, cosyntropin and glucagon cortisol tests showed no significant correlations at Years 2 through 4, which the abstract attributes to decreased numbers.
In plain wordsIn veterans with mild brain injury, the tests did not significantly correlate in later years, which the abstract attributes to fewer people tested.
Peptide
Cosyntropin
Outcome
No significant changeCortisol test correlations at Years 2 through 4
Study
n: not reported in source
Comparator
Glucagon stimulation test
Outcome group
Adrenal Diagnostic Testing · Endocrine and hormones
Source sentences
Summary
Due to decreased numbers, there were no significant correlations at Years 2 through 4.
2 context sentences(design, population, supporting numbers)
Summary · context
We reviewed the utility of the fixed dose Glucagon Stimulation Test (GST) compared with the high dose Cosyntropin Stimulation test (CST) for hypothalamic-pituitary-adrenal (HPA) reserve over time in these patients with mTBI.
Summary · context
We present an interim report of our 4-year longitudinal prospective pilot study of pituitary function in Veterans diagnosed with mTBI.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-9311238103
05HumanNot a test of Cosyntropin aloneObservational studyActivity measurement
In veterans with mild traumatic brain injury, 30-minute cosyntropin cortisol gave correlations with glucagon-test cortisol similar to 60-minute values.
In plain wordsIn veterans with mild brain injury, earlier cosyntropin cortisol values gave similar correlations with glucagon testing.
Peptide
Cosyntropin
Outcome
Not applicableCorrelations using 30-minute cosyntropin cortisol
Study
n: not reported in source
Comparator
Glucagon stimulation test
Outcome group
Adrenal Diagnostic Testing · Endocrine and hormones
Source sentences
Summary
Similar correlations were obtained using the 30-minute CST values.
3 context sentences(design, population, supporting numbers)
Summary · context
Correlations of the cortisol levels from GST vs the 60-minute cortisol from CST were significant at Year 0 (n=22, r=0.553, p=0.008) and at Year 1 (n=18, r=0.802, p<0.0001).
Summary · context
We reviewed the utility of the fixed dose Glucagon Stimulation Test (GST) compared with the high dose Cosyntropin Stimulation test (CST) for hypothalamic-pituitary-adrenal (HPA) reserve over time in these patients with mTBI.
Summary · context
We present an interim report of our 4-year longitudinal prospective pilot study of pituitary function in Veterans diagnosed with mTBI.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-9311238104
06HumanNot a test of Cosyntropin aloneObservational studyActivity measurement
In veterans with mild traumatic brain injury, mean 60-minute cosyntropin cortisol did not significantly differ across Years 0 through 4 (F=1.519, p=0.206).
In plain wordsIn veterans with mild brain injury, mean cosyntropin cortisol results did not significantly differ across follow-up years.
Peptide
Cosyntropin
Outcome
No significant changeCosyntropin cortisol over follow-up years
Study
n: not reported in source
Comparator
Other follow-up years
Outcome group
Adrenal Diagnostic Testing · Endocrine and hormones
Source sentences
Summary
The mean GST cortisol levels and 60-minute CST cortisol levels for subjects at each year were not significantly different over Years 0 through 4 based on ANOVA analyses (CST: F=1.519, p= 0.206; GST: F= 0.796, p=0.532).
2 context sentences(design, population, supporting numbers)
Summary · context
We reviewed the utility of the fixed dose Glucagon Stimulation Test (GST) compared with the high dose Cosyntropin Stimulation test (CST) for hypothalamic-pituitary-adrenal (HPA) reserve over time in these patients with mTBI.
Summary · context
We present an interim report of our 4-year longitudinal prospective pilot study of pituitary function in Veterans diagnosed with mTBI.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-9311238106

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

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Abstract

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