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Study · Not a test of the peptide alone · 2000

3 results

High cell density fermentation of recombinant human thymosin alpha1

Yan Zhen, Zhang Yingqi, Li Min, Chen Changqing

Pharmaceutical Biotechnology1 Jan 2000

PepBankPUB-92916022
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Summary

The text of this summary is not shown here, because the article license does not allow reuse.

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 01LabNot a test of Thymosin alpha-1 aloneOther designOther

    In fed-batch fermentation of E. coli expressing recombinant human thymosin alpha1, the final cell density was more than 60 A600 in three repeated runs.

    In plain wordsIn lab fermentation of bacteria making thymosin alpha1, cell density reached more than 60 A600 in three runs.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableFinal cell density in fed-batch fermentation
    Study

    n: not reported in source

    E. coli Top10/pThio His-Talpha fed-batch fermentation
    Outcome group
    Synthesis and manufacturing · Pharmacology

    Measurements

    Final cell density
    > 60 A600
    5L fed-batch, three repeats

    Source sentences

    Summary
    In three times repeated fermentation, final cell density were all more than 60 A_(600), (relative to 25.6g dry cell weight/L).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 02LabNot a test of Thymosin alpha-1 aloneOther designOther

    In fed-batch fermentation, the average expression of the fusion protein was 42.4% of total bacterial proteins.

    In plain wordsIn lab fermentation, the thymosin alpha1 fusion protein made up 42.4% of the bacterial protein.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableFusion protein expression as share of bacterial protein
    Study

    n: not reported in source

    E. coli Top10/pThio His-Talpha fed-batch fermentation
    Outcome group
    Synthesis and manufacturing · Pharmacology

    Measurements

    Average expression
    42.4 % of total bacterial proteins
    fed-batch

    Source sentences

    Summary
    The average expression was 42.4% of total bacterial proteins.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 03LabNot a test of Thymosin alpha-1 aloneOther designOther

    In fed-batch fermentation, the fused protein content was about 5.7 g/L, equal to 2.4 g/L thymosin alpha.

    In plain wordsIn lab fermentation, the fusion protein yield was about 5.7 g per litre, equal to 2.4 g per litre of thymosin alpha.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableFusion protein yield
    Study

    n: not reported in source

    E. coli Top10/pThio His-Talpha fed-batch fermentation
    Outcome group
    Synthesis and manufacturing · Pharmacology

    Measurements

    Fused protein content
    ≈ 5.7 g/L
    fed-batch
    Thymosin alpha equivalent
    2.4 g/L
    fed-batch

    Source sentences

    Summary
    The content of fused protein was about 5.7 g/L, equal to 2.4 g/L thymosin alpha.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

The source lists no publication types, MeSH terms or keywords.

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