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Study · In vitro (cells) · 2020

1 result

SAT-402 Investigating Analogues of Parathyroid Hormone (PTH) and PTH-Related Peptide (PTHrP) to Improve Anabolic: Catabolic Response Ratios Using UMR106-01 Osteocytic Cells

Oladapo O, Sugamori K, Mitchell J

Journal of the Endocrine Society8 May 2020

PMCIDPMC7209206 (opens in a new tab)PepBankPUB-91562429
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In UMR106-01 osteocytic cells, abaloparatide showed a cellular impedance potency of 1.7 nM, among the highest tested.

    In plain wordsIn cells, abaloparatide had a potency of 1.7 nM in the receptor stimulation assay.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    Not applicableCellular impedance potency
    Study

    n: not reported in source

    UMR106-01 osteocytic cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Potency
    1.7 nM
    abaloparatide cellular impedance assay

    Source sentences

    Summary
    xCELLigence assays showed PTH1-34, PTHrP1-34 and Abaloparatide had the highest potencies (3.7 nM,1.4 nM,1.7nM respectively)
    1 context sentence
    Summary · context
    Screening assays used are UMR106-01 osteocytic cells that have high levels of PTH1R to measure mRNAs involved in anabolic responses (suppression of WNT inhibitors SOST and Dkk1) and catabolic responses (stimulation of RANKL/OPG, IL6).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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