Skip to content

Study · Animal study (in vivo) · rat · 2016

4 results

Mechano-growth factor E peptide promotes healing of rat injured tendon

Zhang B, Luo Q, Kuang D, Ju Y, Song G

Biotechnology letters.1 Oct 2016

PepBankPUB-90767507
Ask about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse.

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with injured Achilles tendons, MGF-C25E treatment significantly increased the Achilles functional index compared with saline.

    In plain wordsIn rats with injured Achilles tendons, MGF-C25E improved the walking function score more than saline.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseAchilles functional index
    Study

    ratn: not reported in source

    Injured Achilles tendon
    Comparator
    Saline-treated tendons
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A significantly increased Achilles functional index was found in the MGF-C25E-treated tendons relative to the saline-treated tendons.
    1 context sentence
    Summary · context
    To determine the possible beneficial effects of a synthetic mechano-growth factor E peptide (MGF-C25E) on the healing of rat Achilles tendon.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with injured Achilles tendons, repair of tendons treated with MGF-C25E (1000 ng/ml) looked superior to saline-treated tendons.

    In plain wordsIn rats with injured Achilles tendons, tendons treated with MGF-C25E looked better repaired than saline-treated tendons.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMacroscopic tendon repair
    Study

    ratn: not reported in source

    Injured Achilles tendon
    Comparator
    Saline-treated tendons
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    1000 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    Macroscopic observation showed that the repair of MGF-C25E-treated (1000 ng/ml) tendons was superior to that of the saline-treated tendons.
    1 context sentence
    Summary · context
    To determine the possible beneficial effects of a synthetic mechano-growth factor E peptide (MGF-C25E) on the healing of rat Achilles tendon.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with injured Achilles tendons, MGF-C25E (1000 ng/ml) significantly increased the stiffness of repaired tendons compared with saline.

    In plain wordsIn rats with injured Achilles tendons, repaired tendons were stiffer with MGF-C25E than with saline.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseStiffness of repaired tendon
    Study

    ratn: not reported in source

    Injured Achilles tendon
    Comparator
    Saline-treated tendons
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    1000 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    The mean value of the stiffness of the repaired tendons was significantly increased in the MGF-C25E-treated (1000 ng/ml) tendons relative to the saline-treated tendons.
    1 context sentence
    Summary · context
    To determine the possible beneficial effects of a synthetic mechano-growth factor E peptide (MGF-C25E) on the healing of rat Achilles tendon.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with injured Achilles tendons, histology of MGF-C25E-treated tendons gave evidence of tissue remodeling and cell alignment.

    In plain wordsIn rats with injured Achilles tendons, tissue slides showed signs of remodeling and cell alignment after MGF-C25E.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableHistological tissue remodeling and cell alignment
    Study

    ratn: not reported in source

    Injured Achilles tendon
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, histological analysis provided evidence of tissue remodeling and cell alignment.
    1 context sentence
    Summary · context
    To determine the possible beneficial effects of a synthetic mechano-growth factor E peptide (MGF-C25E) on the healing of rat Achilles tendon.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.