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Study · Not a test of the peptide alone · 2021

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Model of therapeutic intervention in anorexia nervosa of adolescents with depressive behavioral disorders

Mykhailova I, Mitelov D, Matkovska T, Mayorov O

European psychiatry : the journal of the Association of European Psychiatrists13 Aug 2021

PMCIDPMC9528209 (opens in a new tab)PepBankPUB-90475786
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Summary

Introduction Anorexia nervosa is often associated with the development of depressive disorders. Objectives Skillful dissimulation of the true causes of fasting in adolescents leads to diagnostic errors and delayed adequate therapy. Methods The study design includes clinical psychopathological, somatic-neurological, and psychological methods for examination of 54 adolescent girls aged 12-14, with a recurrent depression, and factors determine disorders in alimentary behavior (anorexia nervosa) in teen-agers. The following psychological tests were performed: Children’s Depression Rating Scale Revised, Columbia - Suicide Severity Rating Scale, Mendelevitch - Yakhin Scale to establish a neurotic state. Results in all adolescent girls with anorexia nervosa depressive disorders were present in prepuberty. Behavioral syndrome and aggressive vulnerability prevailed in the structure of depression. Cognitive component was represented in the form of unstable type of poor memory and decreased rate of sensorimotor reactions with episodic recurrent attacks of bulimia. Our model of therapeutic intervention included: behavioral intervention, intravenous administration of Cerebrolysin 10,0 with 0,9 % Sodium chloride 200,0 (No.15). Therapeutic neuroplasticity, multimodal effect, and a disease - modifying therapy effects in short terms provide regression of emotional-cognitivity. Conclusions In adolescent girls with a recurrent depression anorexia nervosa has specific features that require early differentiation, neurotropic and neurodegenerative therapy.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

  1. 01HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In adolescent girls with anorexia and recurrent depression, a model including behavioral intervention and Cerebrolysin reportedly reduced emotional-cognitive symptoms.

    In plain wordsIn adolescent girls with anorexia and depression, a model including behavioral intervention and Cerebrolysin reportedly reduced emotional-cognitive symptoms.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseEmotional-cognitive symptoms
    Study

    n: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    Therapeutic neuroplasticity, multimodal effect, and a disease - modifying therapy effects in short terms provide regression of emotional-cognitivity.
    2 context sentences
    Summary · context
    The study design includes clinical psychopathological, somatic-neurological, and psychological methods for examination of 54 adolescent girls aged 12-14, with a recurrent depression, and factors determine disorders in alimentary behavior (anorexia nervosa) in teen-agers.
    Summary · context
    Our model of therapeutic intervention included: behavioral intervention, intravenous administration of Cerebrolysin 10,0 with 0,9 % Sodium chloride 200,0 (No.15).

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

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