Skip to content

Study · Measured the body's own peptide · 2004

4 results

An investigation of IGF-I isoforms in human skeletal muscle : the effects of age and exercise

Hammeed M

University College London (University of London)1 Jan 2004

PepBankPUB-90319247
Source linkAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyMechanism

    In young and old subjects, resting muscle levels of MGF did not differ significantly between age groups.

    In plain wordsAt rest, the body's own MGF levels in muscle were similar in young and old people.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeResting MGF levels, young versus old
    Study

    n = 15

    Comparator
    Old subjects
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    At rest there were no significant differences between resting levels of either isoform between the young and old subjects.
    2 context sentences
    Summary · context
    This thesis has focussed on the expression of the different insulin like growth factor-I (IGF-I) isoforms (IGF-IEa, IGF-IEb and MGF) in human skeletal muscle, with specific reference to exercise and the ageing process.
    Summary · context
    The acute response of IGF-IEa and MGF to a single bout of high resistance exercise was studied in young (n 8, age 29.5 1.5 years) and old (n 7, age 74.4 1.8 years) subjects.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyMechanism

    In young subjects, the mechano-sensitive isoform MGF was significantly upregulated 2.5 hours after a single bout of high resistance exercise.

    In plain wordsIn young people, the body's own MGF in muscle rose 2.5 hours after one bout of heavy exercise.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF after high resistance exercise, young
    Study

    n = 8

    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Measurements

    Time after exercise
    2.5 hours
    young subjects

    Source sentences

    Summary
    The study showed that when measured 2.5 hours after the end of the exercise bout, the mechano-sensitive isoform, MGF, was significantly upregulated in the young but not the old subjects (P 0.05).
    2 context sentences
    Summary · context
    This thesis has focussed on the expression of the different insulin like growth factor-I (IGF-I) isoforms (IGF-IEa, IGF-IEb and MGF) in human skeletal muscle, with specific reference to exercise and the ageing process.
    Summary · context
    The acute response of IGF-IEa and MGF to a single bout of high resistance exercise was studied in young (n 8, age 29.5 1.5 years) and old (n 7, age 74.4 1.8 years) subjects.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyMechanism

    In old subjects, MGF was not significantly upregulated 2.5 hours after a single bout of high resistance exercise.

    In plain wordsIn older people, the body's own MGF in muscle did not rise 2.5 hours after one bout of heavy exercise.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeMGF after high resistance exercise, old
    Study

    n = 7

    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Measurements

    Time after exercise
    2.5 hours
    old subjects

    Source sentences

    Summary
    The study showed that when measured 2.5 hours after the end of the exercise bout, the mechano-sensitive isoform, MGF, was significantly upregulated in the young but not the old subjects (P 0.05).
    2 context sentences
    Summary · context
    This thesis has focussed on the expression of the different insulin like growth factor-I (IGF-I) isoforms (IGF-IEa, IGF-IEb and MGF) in human skeletal muscle, with specific reference to exercise and the ageing process.
    Summary · context
    The acute response of IGF-IEa and MGF to a single bout of high resistance exercise was studied in young (n 8, age 29.5 1.5 years) and old (n 7, age 74.4 1.8 years) subjects.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyMechanism

    In situ hybridisation with MGF-specific oligo probes confirmed MGF mRNA localisation within muscle fibres.

    In plain wordsA lab stain showed the body's own MGF messages are located inside muscle fibres.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableMGF mRNA localisation in muscle fibres
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    Furthermore, in situ hybridisation using oligo probes specific for MGF mRNA confirmed its localisation within the muscle fibres
    2 context sentences
    Summary · context
    This thesis has focussed on the expression of the different insulin like growth factor-I (IGF-I) isoforms (IGF-IEa, IGF-IEb and MGF) in human skeletal muscle, with specific reference to exercise and the ageing process.
    Summary · context
    The acute response of IGF-IEa and MGF to a single bout of high resistance exercise was studied in young (n 8, age 29.5 1.5 years) and old (n 7, age 74.4 1.8 years) subjects.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.