In children with achondroplasia, median total AHI was 3.2 events/hour with vosoritide versus 6.9 without treatment, without statistical significance (p = 0.105).
In plain wordsChildren with achondroplasia receiving vosoritide had lower median AHI than untreated children, but the difference was not significant.
- Peptide
- Vosoritide
- Outcome
- DecreaseTotal apnea-hypopnea index
- Study
n: not reported in source
- Comparator
- Children not receiving vosoritide
- Outcome group
- Sleep · Respiratory
- Studied dose
- Dose not stated
Measurements
- Median total AHI
- 3.2 events/hour
- vosoritide
- Median total AHI
- 6.9 events/hour
- untreated
- p
- 0.105
Source sentences
Median total AHI was 3.2 events/hour in children receiving vosoritide and 6.9 in those not receiving treatment (p = 0.105).
2 context sentences(design, population, supporting numbers)
This retrospective study included 49 children evaluated between March 2016 and February 2025.
Total AHI was compared according to sex, upper airway surgery history, foramen magnum stenosis, and vosoritide treatment.