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Study · Observational study · 2026

1 result

Differentiating hypothalamic from pituitary adrenal insufficiency: underlying causes and diagnostic utility of the corticotropin-releasing hormone and growth hormone-releasing peptide-2 stimulation tests.

Okada N, Nakagawa T, Murahashi N, Kurosu T, Kusuda S, Kaneko C, Hishida Y, Nakamura Y, Asai S, Yokota K, Sone M

Endocrine journal11 Sept 2026

PMID42732957 (opens in a new tab)DOI10.1507/endocrj.ej26-0192 (opens in a new tab)PepBankPUB-42732957
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanObservational studyOther

    In patients with normal cortisol responses to CRH, a peak cortisol level below 12 μg/dL in the GHRP‑2 stimulation test was specific to hypothalamic secondary adrenal insufficiency.

    In plain wordsIn patients with normal cortisol responses to CRH, a low cortisol peak after a GHRP‑2 test pointed to a hypothalamic cause of adrenal insufficiency.

    Peptide
    GHRP-2
    Outcome
    Not applicablePeak cortisol below 12 ug/dL in the GHRP-2 test as marker of hypothalamic secondary adrenal insufficiency
    Study

    n: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Peak cortisol cut-off
    < 12 μg/dL
    GHRP-2 stimulation test

    Source sentences

    Summary
    In addition, a peak cortisol level <12 μg/dL in the growth hormone-releasing peptide-2 (GHRP-2) stimulation test was also specific to hypothalamic SAI among patients with normal cortisol responses to CRH.
    1 context sentence
    Summary · context
    We retrospectively analyzed 69 patients who underwent both tests between August 2015 and December 2024.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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