NAP peptide modulated proteome profiling of rat brain cortex under hypobaric hypoxia.

Sharma NK, Bhargava K

Respiratory physiology & neurobiology11 Sept 2026

PMID42727869DOI10.1016/j.resp.2026.104648PepBankPUB-42727869

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In hypoxic rats, comparison with NAP supplementation identified both upregulated and downregulated cortical proteins in both groups.
In plain wordsIn hypoxic rats, cortical proteins increased and decreased in both the hypoxia and NAP-supplemented groups.
Peptide
Davunetide
Outcome
MixedCortical protein regulation
Study
ratn: not reported in source
hypobaric hypoxia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Comparison of proteome profiling of hypoxia and NAP-supplemented rats enabled us to identify the number of proteins upregulated as well as downregulated in both groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats from the hypoxia group as well as from NAP supplemented hypoxia group were subjected to heights of 25000 ft for 3, 6, and 12 hrs.
Report a problemFND-4272786901
02AnimalAnimal study (in vivo)Mechanism
In hypoxic rats, Nrf2-mediated oxidative stress response occurred in both the NAP-supplemented and hypoxia groups.
In plain wordsIn hypoxic rats, both groups showed an Nrf2-mediated oxidative stress response, including the NAP group.
Peptide
Davunetide
Outcome
Not applicableNrf2-mediated oxidative stress response
Study
ratn: not reported in source
hypobaric hypoxia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Nrf2-mediated oxidative stress response was observed in both groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats from the hypoxia group as well as from NAP supplemented hypoxia group were subjected to heights of 25000 ft for 3, 6, and 12 hrs.
Report a problemFND-4272786902
03AnimalAnimal study (in vivo)Mechanism
In hypoxic rats, NAP supplementation showed antioxidant and free radical detoxification processes, while hypoxia alone showed energy-regulated processes.
In plain wordsIn hypoxic rats, NAP supplementation showed antioxidant and detoxification processes compared with energy-regulated processes in the hypoxia group.
Peptide
Davunetide
Outcome
Not applicableAntioxidant and free radical detoxification processes
Study
ratn: not reported in source
hypobaric hypoxia
Comparator
Hypoxia group
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A comparison of biological processes showed energy-regulated biological processes in the hypoxia group while antioxidant and free radical detoxification in NAP supplemented group.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats from the hypoxia group as well as from NAP supplemented hypoxia group were subjected to heights of 25000 ft for 3, 6, and 12 hrs.
Report a problemFND-4272786903
04AnimalAnimal study (in vivo)Mechanism
In hypoxic rats, NAP supplementation increased expression of certain reactive oxygen species-related proteins versus the hypoxic group.
In plain wordsIn hypoxic rats, NAP increased certain proteins related to reactive oxygen species compared with the hypoxic group.
Peptide
Davunetide
Outcome
IncreaseReactive oxygen species-related proteins
Study
ratn: not reported in source
hypobaric hypoxia
Comparator
Hypoxic group
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Additionally, overexpression of certain proteins related to reactive oxygen species and upregulation of peroxiredoxins was identified in NAP supplemented group versus the hypoxic group.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats from the hypoxia group as well as from NAP supplemented hypoxia group were subjected to heights of 25000 ft for 3, 6, and 12 hrs.
Report a problemFND-4272786904
05AnimalAnimal study (in vivo)Mechanism
In hypoxic rats, NAP supplementation increased peroxiredoxins versus the hypoxic group.
In plain wordsIn hypoxic rats, NAP increased peroxiredoxins compared with the hypoxic group.
Peptide
Davunetide
Outcome
IncreasePeroxiredoxins
Study
ratn: not reported in source
hypobaric hypoxia
Comparator
Hypoxic group
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Additionally, overexpression of certain proteins related to reactive oxygen species and upregulation of peroxiredoxins was identified in NAP supplemented group versus the hypoxic group.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats from the hypoxia group as well as from NAP supplemented hypoxia group were subjected to heights of 25000 ft for 3, 6, and 12 hrs.
Report a problemFND-4272786905
06AnimalAnimal study (in vivo)Mechanism
In hypoxia-exposed rat cortex, the GSH/GSSG ratio showed no significant decrease after NAP supplementation.
In plain wordsIn hypoxic rats, the cortical GSH/GSSG ratio did not decrease significantly after NAP supplementation.
Peptide
Davunetide
Outcome
No significant changeGSH/GSSG ratio
Study
ratn: not reported in source
hypobaric hypoxia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The GSH/GSSG ratio was discovered to be decreased in hypoxia-exposed rat brain cortex and no significant decrease was observed after NAP supplementation.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats from the hypoxia group as well as from NAP supplemented hypoxia group were subjected to heights of 25000 ft for 3, 6, and 12 hrs.
Report a problemFND-4272786906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

Keywords

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