Skip to content

Study · Systematic review · 2026

8 results

The Regenerative Potential of GHK-Cu in Aesthetic Medicine.

Mokhtar J, Mohamad B, Haddad J, Said A, Menon A, Kreutz-Rodrigues L, Vyas KS, Cetrulo CL Jr, Lellouch AG

Aesthetic surgery journal20 Aug 2026

PMID42619529 (opens in a new tab)DOI10.1093/asj/sjag169 (opens in a new tab)PepBankPUB-42619529
Publisher pagePubMedAsk about this study
Jump to 8 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 3 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In a systematic review, clinical studies showed that GHK‑Cu improved patient-reported satisfaction after laser resurfacing.

    In plain wordsA review of studies found that GHK‑Cu was linked to higher patient satisfaction after laser skin resurfacing.

    Peptide
    GHK-Cu
    Outcome
    IncreasePatient-reported satisfaction after laser resurfacing
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Clinically, GHK-Cu improved patient-reported satisfaction after laser resurfacing and significantly reduced wrinkle volume and depth compared with controls.
    1 context sentence
    Summary · context
    20 studies (18 preclinical; 2 RCTs) were included.
  2. 02HumanSystematic reviewEfficacy outcome

    In a systematic review, clinical studies showed that GHK‑Cu significantly reduced wrinkle volume compared with controls.

    In plain wordsA review of studies found that GHK‑Cu was linked to less wrinkle volume than in controls.

    Peptide
    GHK-Cu
    Outcome
    DecreaseWrinkle volume
    Study

    n: not reported in source

    Comparator
    Controls
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Clinically, GHK-Cu improved patient-reported satisfaction after laser resurfacing and significantly reduced wrinkle volume and depth compared with controls.
    1 context sentence
    Summary · context
    20 studies (18 preclinical; 2 RCTs) were included.
  3. 03HumanSystematic reviewEfficacy outcome

    In a systematic review, clinical studies showed that GHK‑Cu significantly reduced wrinkle depth compared with controls.

    In plain wordsA review of studies found that GHK‑Cu was linked to shallower wrinkles than in controls.

    Peptide
    GHK-Cu
    Outcome
    DecreaseWrinkle depth
    Study

    n: not reported in source

    Comparator
    Controls
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Clinically, GHK-Cu improved patient-reported satisfaction after laser resurfacing and significantly reduced wrinkle volume and depth compared with controls.
    1 context sentence
    Summary · context
    20 studies (18 preclinical; 2 RCTs) were included.
  4. 04AnimalOther designEfficacy outcome

    In preclinical models included in the review, GHK‑Cu enhanced extracellular matrix synthesis, including type I collagen and glycosaminoglycans.

    In plain wordsIn preclinical studies, GHK‑Cu increased production of collagen and other skin support molecules.

    Peptide
    GHK-Cu
    Outcome
    IncreaseExtracellular matrix synthesis (type I collagen and glycosaminoglycans)
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Preclinical data consistently demonstrated that GHK-Cu enhances extracellular matrix synthesis (type I collagen and glycosaminoglycans), modulates metalloproteinase activity, and promotes angiogenesis and cellular proliferation.
    1 context sentence
    Summary · context
    20 studies (18 preclinical; 2 RCTs) were included.
  5. 05AnimalOther designEfficacy outcome

    In preclinical models included in the review, GHK‑Cu modulated metalloproteinase activity.

    In plain wordsIn preclinical studies, GHK‑Cu changed the activity of enzymes that break down tissue matrix.

    Peptide
    GHK-Cu
    Outcome
    MixedMetalloproteinase activity
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Preclinical data consistently demonstrated that GHK-Cu enhances extracellular matrix synthesis (type I collagen and glycosaminoglycans), modulates metalloproteinase activity, and promotes angiogenesis and cellular proliferation.
    1 context sentence
    Summary · context
    20 studies (18 preclinical; 2 RCTs) were included.
  6. 06AnimalOther designEfficacy outcome

    In preclinical models included in the review, GHK‑Cu promoted angiogenesis and cellular proliferation.

    In plain wordsIn preclinical studies, GHK‑Cu increased new blood vessel growth and cell multiplication.

    Peptide
    GHK-Cu
    Outcome
    IncreaseAngiogenesis and cellular proliferation
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Preclinical data consistently demonstrated that GHK-Cu enhances extracellular matrix synthesis (type I collagen and glycosaminoglycans), modulates metalloproteinase activity, and promotes angiogenesis and cellular proliferation.
    1 context sentence
    Summary · context
    20 studies (18 preclinical; 2 RCTs) were included.
  7. 07AnimalOther designEfficacy outcome

    In preclinical models included in the review, GHK‑Cu exhibited significant anti-inflammatory effects by suppressing TGF-β and IL-6.

    In plain wordsIn preclinical studies, GHK‑Cu lowered the inflammatory signals TGF-β and IL-6.

    Peptide
    GHK-Cu
    Outcome
    DecreaseTGF-β and IL-6 suppression
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It also exhibited significant anti-inflammatory effects by suppressing TGF-β and IL-6.
    1 context sentence
    Summary · context
    20 studies (18 preclinical; 2 RCTs) were included.
  8. 08AnimalOther designPharmacokinetics

    In preclinical studies included in the review, advanced delivery systems such as microneedles and liposomes markedly improved GHK‑Cu transdermal bioavailability and efficacy.

    In plain wordsIn preclinical studies in a review, microneedles and liposomes improved how well GHK‑Cu crossed the skin and worked.

    Peptide
    GHK-Cu
    Outcome
    IncreaseTransdermal bioavailability and efficacy with advanced delivery systems
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, advanced delivery systems, including microneedles and liposomes, markedly improved its transdermal bioavailability and efficacy.
    1 context sentence
    Summary · context
    20 studies (18 preclinical; 2 RCTs) were included.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.