Synergistic Effects of Cerebrolysin and Aerobic Exercise on 6-hydroxydopamine-induced Model of Parkinson Disease in Adult Male Rats.

Athari SZ, Farajdokht F, Mohajeri D, Nourazar MA

Basic and clinical neuroscience1 Mar 2025

PMID42382515PMCIDPMC13318195DOI10.32598/bcn.2025.6378.1PepBankPUB-42382515

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study16

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In Parkinson disease model rats, CBL alone decreased ipsilateral apomorphine rotation.
In plain wordsIn rats with Parkinson disease, CBL alone reduced ipsilateral apomorphine rotation.
Peptide
Cerebrolysin
Outcome
DecreaseIpsilateral apomorphine rotation
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
2.5 mL/kg · intraperitoneal · three weeksAs given in this study (rat).
Source sentences
Summary
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
2 context sentences(design, population, supporting numbers)
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Report a problemFND-4238251501
02AnimalAnimal study (in vivo)Efficacy outcome
In Parkinson disease model rats, CBL alone decreased muscle rigidity.
In plain wordsIn rats with Parkinson disease, CBL alone reduced muscle rigidity.
Peptide
Cerebrolysin
Outcome
DecreaseMuscle rigidity
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
2.5 mL/kg · intraperitoneal · three weeksAs given in this study (rat).
Source sentences
Summary
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
2 context sentences(design, population, supporting numbers)
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Report a problemFND-4238251502
03AnimalAnimal study (in vivo)Mechanism
In Parkinson disease model rats, behavioral improvements with CBL alone were associated with reduced MDA levels.
In plain wordsIn rats with Parkinson disease, behavioral improvements with CBL alone were linked to lower MDA levels.
Peptide
Cerebrolysin
Outcome
DecreaseMalondialdehyde levels
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
2.5 mL/kg · intraperitoneal · three weeksAs given in this study (rat).
Source sentences
Summary
Moreover, these behavioral changes were associated with reduced malondialdehyde (MDA) levels and α-synuclein protein levels, increased TAC level and GPx activity, and a greater neuronal count in the SN.
3 context sentences(design, population, supporting numbers)
Summary · context
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
Report a problemFND-4238251505
04AnimalAnimal study (in vivo)Mechanism
In Parkinson disease model rats, behavioral improvements with CBL alone were associated with reduced α-synuclein protein levels.
In plain wordsIn rats with Parkinson disease, behavioral improvements with CBL alone were linked to lower α-synuclein protein levels.
Peptide
Cerebrolysin
Outcome
Decreaseα-synuclein protein levels
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
2.5 mL/kg · intraperitoneal · three weeksAs given in this study (rat).
Source sentences
Summary
Moreover, these behavioral changes were associated with reduced malondialdehyde (MDA) levels and α-synuclein protein levels, increased TAC level and GPx activity, and a greater neuronal count in the SN.
3 context sentences(design, population, supporting numbers)
Summary · context
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
Report a problemFND-4238251506
05AnimalAnimal study (in vivo)Mechanism
In Parkinson disease model rats, behavioral improvements with CBL alone were associated with increased TAC.
In plain wordsIn rats with Parkinson disease, behavioral improvements with CBL alone were linked to higher total antioxidant capacity.
Peptide
Cerebrolysin
Outcome
IncreaseTotal antioxidant capacity
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
2.5 mL/kg · intraperitoneal · three weeksAs given in this study (rat).
Source sentences
Summary
Moreover, these behavioral changes were associated with reduced malondialdehyde (MDA) levels and α-synuclein protein levels, increased TAC level and GPx activity, and a greater neuronal count in the SN.
3 context sentences(design, population, supporting numbers)
Summary · context
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
Report a problemFND-4238251507
06AnimalAnimal study (in vivo)Mechanism
In Parkinson disease model rats, behavioral improvements with CBL alone were associated with increased GPx activity.
In plain wordsIn rats with Parkinson disease, behavioral improvements with CBL alone were linked to higher glutathione peroxidase activity.
Peptide
Cerebrolysin
Outcome
IncreaseGlutathione peroxidase activity
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
2.5 mL/kg · intraperitoneal · three weeksAs given in this study (rat).
Source sentences
Summary
Moreover, these behavioral changes were associated with reduced malondialdehyde (MDA) levels and α-synuclein protein levels, increased TAC level and GPx activity, and a greater neuronal count in the SN.
3 context sentences(design, population, supporting numbers)
Summary · context
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
Report a problemFND-4238251508
07AnimalAnimal study (in vivo)Efficacy outcome
In Parkinson disease model rats, behavioral improvements with CBL alone were associated with greater substantia nigra neuronal counts.
In plain wordsIn rats with Parkinson disease, behavioral improvements with CBL alone were linked to more substantia nigra neurons.
Peptide
Cerebrolysin
Outcome
IncreaseSubstantia nigra neuronal count
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
2.5 mL/kg · intraperitoneal · three weeksAs given in this study (rat).
Source sentences
Summary
Moreover, these behavioral changes were associated with reduced malondialdehyde (MDA) levels and α-synuclein protein levels, increased TAC level and GPx activity, and a greater neuronal count in the SN.
3 context sentences(design, population, supporting numbers)
Summary · context
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
Report a problemFND-4238251509

Studies that did not test the peptide alone9

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

08AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In Parkinson disease model rats, CBL with exercise decreased ipsilateral apomorphine rotation.
In plain wordsIn rats with Parkinson disease, CBL with exercise reduced ipsilateral apomorphine rotation.
Peptide
Cerebrolysin
Outcome
DecreaseIpsilateral apomorphine rotation with combination
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Outcome group
Exercise and physical function · Nervous system and cognition
Source sentences
Summary
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
2 context sentences(design, population, supporting numbers)
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4238251503
09AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In Parkinson disease model rats, CBL with exercise decreased muscle rigidity.
In plain wordsIn rats with Parkinson disease, CBL with exercise reduced muscle rigidity.
Peptide
Cerebrolysin
Outcome
DecreaseMuscle rigidity with combination
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Outcome group
Exercise and physical function · Nervous system and cognition
Source sentences
Summary
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
2 context sentences(design, population, supporting numbers)
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4238251504
10AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In Parkinson disease model rats, behavioral improvements with CBL and exercise were associated with reduced MDA levels.
In plain wordsIn rats with Parkinson disease, improvements with CBL and exercise were linked to lower MDA levels.
Peptide
Cerebrolysin
Outcome
DecreaseMalondialdehyde levels with combination
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Moreover, these behavioral changes were associated with reduced malondialdehyde (MDA) levels and α-synuclein protein levels, increased TAC level and GPx activity, and a greater neuronal count in the SN.
3 context sentences(design, population, supporting numbers)
Summary · context
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4238251510
11AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In Parkinson disease model rats, behavioral improvements with CBL and exercise were associated with reduced α-synuclein protein levels.
In plain wordsIn rats with Parkinson disease, improvements with CBL and exercise were linked to lower α-synuclein protein levels.
Peptide
Cerebrolysin
Outcome
Decreaseα-synuclein levels with combination
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Moreover, these behavioral changes were associated with reduced malondialdehyde (MDA) levels and α-synuclein protein levels, increased TAC level and GPx activity, and a greater neuronal count in the SN.
3 context sentences(design, population, supporting numbers)
Summary · context
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4238251511
12AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In Parkinson disease model rats, behavioral improvements with CBL and exercise were associated with increased TAC.
In plain wordsIn rats with Parkinson disease, improvements with CBL and exercise were linked to higher total antioxidant capacity.
Peptide
Cerebrolysin
Outcome
IncreaseTotal antioxidant capacity with combination
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Moreover, these behavioral changes were associated with reduced malondialdehyde (MDA) levels and α-synuclein protein levels, increased TAC level and GPx activity, and a greater neuronal count in the SN.
3 context sentences(design, population, supporting numbers)
Summary · context
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4238251512
13AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In Parkinson disease model rats, behavioral improvements with CBL and exercise were associated with increased GPx activity.
In plain wordsIn rats with Parkinson disease, improvements with CBL and exercise were linked to higher GPx activity.
Peptide
Cerebrolysin
Outcome
IncreaseGPx activity with combination
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Moreover, these behavioral changes were associated with reduced malondialdehyde (MDA) levels and α-synuclein protein levels, increased TAC level and GPx activity, and a greater neuronal count in the SN.
3 context sentences(design, population, supporting numbers)
Summary · context
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4238251513
14AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In Parkinson disease model rats, behavioral improvements with CBL and exercise were associated with greater substantia nigra neuronal counts.
In plain wordsIn rats with Parkinson disease, improvements with CBL and exercise were linked to more substantia nigra neurons.
Peptide
Cerebrolysin
Outcome
IncreaseNeuronal count with combination
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Moreover, these behavioral changes were associated with reduced malondialdehyde (MDA) levels and α-synuclein protein levels, increased TAC level and GPx activity, and a greater neuronal count in the SN.
3 context sentences(design, population, supporting numbers)
Summary · context
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4238251514
15AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In Parkinson disease model rats, CBL and exercise combination effects exceeded single therapy effects.
In plain wordsIn rats with Parkinson disease, CBL and exercise had greater effects than single therapy.
Peptide
Cerebrolysin
Outcome
IncreaseOverall combination effects versus single therapy
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Comparator
Single therapy
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Notably, the combination effects were greater than single therapy and levodopa treatment.
3 context sentences(design, population, supporting numbers)
Summary · context
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4238251515
16AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In Parkinson disease model rats, CBL and exercise combination effects exceeded levodopa treatment effects.
In plain wordsIn rats with Parkinson disease, CBL and exercise had greater effects than levodopa.
Peptide
Cerebrolysin
Outcome
IncreaseOverall combination effects versus levodopa
Study
ratn: not reported in source
Male Wistar rats with 6-OHDA-induced Parkinson disease
Comparator
Levodopa
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Notably, the combination effects were greater than single therapy and levodopa treatment.
3 context sentences(design, population, supporting numbers)
Summary · context
The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals.
Summary · context
This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA).
Summary · context
PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks)
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4238251516

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

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