Self-assembled manganese-based nanoplatforms synergizing immunogenic cell death and STING activation for triple-negative breast cancer.

Yang M, Qin M, Liu Y, Li J, Yin Y, Huang Y, Yu M, Gong J, Chen S, Wang J, Zhou Q, Zhang X, Li G

Materials today. Bio19 Jun 2026

PMID42376245PMCIDPMC13312589DOI10.1016/j.mtbio.2026.103364PepBankPUB-42376245

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone11

In this study, LTX-315 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking LTX-315.

01AnimalNot a test of LTX-315 aloneAnimal study (in vivo)Efficacy outcome
In mice with orthotopic triple-negative breast cancer, HLM315 inhibited tumor growth.
In plain wordsIn mice with breast tumors, HLM315 inhibited tumor growth.
Peptide
LTX-315
Outcome
DecreaseTumor growth
Study
mousen: not reported in source
orthotopic triple-negative breast cancer
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Ultimately, HLM315 systematically reshaped the TME and potently inhibited the tumor growth in TNBC orthotopic mouse model.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we developed a manganese-based nanoparticle, termed HLM315, via one-step self-assembly of alendronate-modified hyaluronic acid (HA-AL), the amphiphilic cationic peptide LTX-315, and Mn²⁺ under weakly alkaline conditions.
In this study, LTX-315 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LTX-315.
Report a problemFND-4237624509
02AnimalNot a test of LTX-315 aloneAnimal study (in vivo)Mechanism
In mice with orthotopic triple-negative breast cancer, HLM315 reshaped the tumor microenvironment.
In plain wordsIn mice with breast tumors, HLM315 changed the tumor microenvironment.
Peptide
LTX-315
Outcome
Not applicableTumor microenvironment remodeling
Study
mousen: not reported in source
orthotopic triple-negative breast cancer
Outcome group
Immune response · Cancer
Source sentences
Summary
Ultimately, HLM315 systematically reshaped the TME and potently inhibited the tumor growth in TNBC orthotopic mouse model.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we developed a manganese-based nanoparticle, termed HLM315, via one-step self-assembly of alendronate-modified hyaluronic acid (HA-AL), the amphiphilic cationic peptide LTX-315, and Mn²⁺ under weakly alkaline conditions.
In this study, LTX-315 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LTX-315.
Report a problemFND-4237624510
03AnimalNot a test of LTX-315 aloneOther designPharmacokinetics
In tumor models, HLM315 targeted tumors and released LTX‑315 in response to the tumor microenvironment.
In plain wordsIn tumor models, HLM315 targeted tumors and released LTX‑315 in response to local conditions.
Peptide
LTX-315
Outcome
Not applicableTumor targeting and peptide release
Study
n: not reported in source
HLM315 nanoparticle tumor models
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
HLM315 actively targeted tumors and responded to the TME, releasing LTX-315 and generating Mn²⁺.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we developed a manganese-based nanoparticle, termed HLM315, via one-step self-assembly of alendronate-modified hyaluronic acid (HA-AL), the amphiphilic cationic peptide LTX-315, and Mn²⁺ under weakly alkaline conditions.
In this study, LTX-315 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LTX-315.
Report a problemFND-4237624501
04AnimalNot a test of LTX-315 aloneOther designMechanism
In the HLM315 combination system containing LTX‑315 and manganese, tumor membrane disruption induced immunogenic cell death.
In plain wordsIn the HLM315 combination system, tumor membrane disruption induced cell death that stimulates immunity.
Peptide
LTX-315
Outcome
IncreaseImmunogenic cell death
Study
n: not reported in source
HLM315 nanoparticle tumor models
Outcome group
Immune response · Cancer
Source sentences
Summary
LTX-315 induced immunogenic cell death (ICD) through tumor membrane disruption and release of tumor antigens and damage-associated molecular patterns (DAMPs), thereby providing an initial signal for immune activation.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we developed a manganese-based nanoparticle, termed HLM315, via one-step self-assembly of alendronate-modified hyaluronic acid (HA-AL), the amphiphilic cationic peptide LTX-315, and Mn²⁺ under weakly alkaline conditions.
In this study, LTX-315 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LTX-315.
Report a problemFND-4237624502
05AnimalNot a test of LTX-315 aloneOther designMechanism
In the HLM315 combination system containing LTX‑315 and manganese, tumor membrane disruption released tumor antigens.
In plain wordsIn the HLM315 combination system, tumor membrane disruption released tumor antigens.
Peptide
LTX-315
Outcome
IncreaseTumor antigen release
Study
n: not reported in source
HLM315 nanoparticle tumor models
Outcome group
Immune response · Cancer
Source sentences
Summary
LTX-315 induced immunogenic cell death (ICD) through tumor membrane disruption and release of tumor antigens and damage-associated molecular patterns (DAMPs), thereby providing an initial signal for immune activation.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we developed a manganese-based nanoparticle, termed HLM315, via one-step self-assembly of alendronate-modified hyaluronic acid (HA-AL), the amphiphilic cationic peptide LTX-315, and Mn²⁺ under weakly alkaline conditions.
In this study, LTX-315 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LTX-315.
Report a problemFND-4237624503
06AnimalNot a test of LTX-315 aloneOther designMechanism
In the HLM315 combination system containing LTX‑315 and manganese, tumor membrane disruption released damage-associated molecular patterns.
In plain wordsIn the HLM315 combination system, tumor membrane disruption released danger signals.
Peptide
LTX-315
Outcome
IncreaseDAMP release
Study
n: not reported in source
HLM315 nanoparticle tumor models
Outcome group
Immune response · Cancer
Source sentences
Summary
LTX-315 induced immunogenic cell death (ICD) through tumor membrane disruption and release of tumor antigens and damage-associated molecular patterns (DAMPs), thereby providing an initial signal for immune activation.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we developed a manganese-based nanoparticle, termed HLM315, via one-step self-assembly of alendronate-modified hyaluronic acid (HA-AL), the amphiphilic cationic peptide LTX-315, and Mn²⁺ under weakly alkaline conditions.
In this study, LTX-315 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LTX-315.
Report a problemFND-4237624504
07AnimalNot a test of LTX-315 aloneOther designMechanism
In tumor models, combined HLM315 mechanisms promoted type I interferon production.
In plain wordsIn tumor models, combined HLM315 mechanisms increased type I interferon production.
Peptide
LTX-315
Outcome
IncreaseType I interferon production
Study
n: not reported in source
HLM315 nanoparticle tumor models
Outcome group
Immune response · Cancer
Source sentences
Summary
Together, these mechanisms synergistically promoted type I interferon production, dendritic cell (DC) maturation, T-cell recruitment and activation, and elicited an enhanced immunological memory.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we developed a manganese-based nanoparticle, termed HLM315, via one-step self-assembly of alendronate-modified hyaluronic acid (HA-AL), the amphiphilic cationic peptide LTX-315, and Mn²⁺ under weakly alkaline conditions.
In this study, LTX-315 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LTX-315.
Report a problemFND-4237624505
08AnimalNot a test of LTX-315 aloneOther designMechanism
In tumor models, combined HLM315 mechanisms promoted dendritic cell maturation.
In plain wordsIn tumor models, combined HLM315 mechanisms promoted dendritic cell maturation.
Peptide
LTX-315
Outcome
IncreaseDendritic cell maturation
Study
n: not reported in source
HLM315 nanoparticle tumor models
Outcome group
Immune response · Cancer
Source sentences
Summary
Together, these mechanisms synergistically promoted type I interferon production, dendritic cell (DC) maturation, T-cell recruitment and activation, and elicited an enhanced immunological memory.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we developed a manganese-based nanoparticle, termed HLM315, via one-step self-assembly of alendronate-modified hyaluronic acid (HA-AL), the amphiphilic cationic peptide LTX-315, and Mn²⁺ under weakly alkaline conditions.
In this study, LTX-315 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LTX-315.
Report a problemFND-4237624506
09AnimalNot a test of LTX-315 aloneOther designMechanism
In tumor models, combined HLM315 mechanisms promoted T-cell recruitment.
In plain wordsIn tumor models, combined HLM315 mechanisms promoted T-cell recruitment.
Peptide
LTX-315
Outcome
IncreaseT-cell recruitment
Study
n: not reported in source
HLM315 nanoparticle tumor models
Outcome group
Immune response · Cancer
Source sentences
Summary
Together, these mechanisms synergistically promoted type I interferon production, dendritic cell (DC) maturation, T-cell recruitment and activation, and elicited an enhanced immunological memory.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we developed a manganese-based nanoparticle, termed HLM315, via one-step self-assembly of alendronate-modified hyaluronic acid (HA-AL), the amphiphilic cationic peptide LTX-315, and Mn²⁺ under weakly alkaline conditions.
In this study, LTX-315 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LTX-315.
Report a problemFND-4237624507
10AnimalNot a test of LTX-315 aloneOther designMechanism
In tumor models, combined HLM315 mechanisms enhanced immunological memory.
In plain wordsIn tumor models, combined HLM315 mechanisms increased immune memory.
Peptide
LTX-315
Outcome
IncreaseImmunological memory
Study
n: not reported in source
HLM315 nanoparticle tumor models
Outcome group
Immune response · Cancer
Source sentences
Summary
Together, these mechanisms synergistically promoted type I interferon production, dendritic cell (DC) maturation, T-cell recruitment and activation, and elicited an enhanced immunological memory.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we developed a manganese-based nanoparticle, termed HLM315, via one-step self-assembly of alendronate-modified hyaluronic acid (HA-AL), the amphiphilic cationic peptide LTX-315, and Mn²⁺ under weakly alkaline conditions.
In this study, LTX-315 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LTX-315.
Report a problemFND-4237624508
11AnimalNot a test of LTX-315 aloneOther designMechanism
In tumor models, combined HLM315 mechanisms promoted T-cell activation.
In plain wordsIn tumor models, combined HLM315 mechanisms promoted T-cell activation.
Peptide
LTX-315
Outcome
IncreaseT-cell activation
Study
n: not reported in source
HLM315 nanoparticle tumor models
Outcome group
Immune response · Cancer
Source sentences
Summary
Together, these mechanisms synergistically promoted type I interferon production, dendritic cell (DC) maturation, T-cell recruitment and activation, and elicited an enhanced immunological memory.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we developed a manganese-based nanoparticle, termed HLM315, via one-step self-assembly of alendronate-modified hyaluronic acid (HA-AL), the amphiphilic cationic peptide LTX-315, and Mn²⁺ under weakly alkaline conditions.
In this study, LTX-315 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LTX-315.
Report a problemFND-4237624511

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.