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Study · Case report or series · n = 1 · 2026

4 results

Biological activation of prolonged delayed fracture healing following abaloparatide under stable circular external fixation: successful limb salvage of a Gustilo type III-C pilon fracture in severe immune thrombocytopenia-a case report.

Nozaka K, Shirahata T, Yuasa Y, Harata S, Miyakoshi N

Journal of medical case reports25 Jun 2026

PMID42351259 (opens in a new tab)PMCIDPMC13339858 (opens in a new tab)DOI10.1186/s13256-026-06289-0 (opens in a new tab)PepBankPUB-42351259
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanCase report or seriesEfficacy outcome

    In a man with prolonged delayed tibial healing, abundant bridging callus appeared within 6 weeks after abaloparatide initiation.

    In plain wordsIn one man with delayed tibial healing, bridging callus appeared within 6 weeks after abaloparatide started.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseBridging callus
    Study

    n = 1

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Within 6 weeks, abundant bridging callus appeared at the tibial fracture site, followed by cortical bridging at 12 weeks without additional intervention.
    2 context sentences
    Summary · context
    A 59-year-old Japanese man with severe immune thrombocytopenia (platelet count approximately 5000/microL) sustained a Gustilo type III-C open pilon fracture after a crush injury.
    Summary · context
    Despite stable fixation, early full weight bearing, and low-intensity pulsed ultrasound therapy, serial radiographs showed minimal progression and absence of bridging callus for more than 8 months. At 9 months after injury, abaloparatide was initiated for a sacral insufficiency fracture associated w…
  2. 02HumanCase report or seriesEfficacy outcome

    In a man with delayed tibial healing, cortical bridging appeared at 12 weeks after abaloparatide initiation without additional intervention.

    In plain wordsIn one man with delayed tibial healing, cortical bridging appeared at 12 weeks after abaloparatide started without additional treatment.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseCortical bridging
    Study

    n = 1

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Within 6 weeks, abundant bridging callus appeared at the tibial fracture site, followed by cortical bridging at 12 weeks without additional intervention.
    2 context sentences
    Summary · context
    A 59-year-old Japanese man with severe immune thrombocytopenia (platelet count approximately 5000/microL) sustained a Gustilo type III-C open pilon fracture after a crush injury.
    Summary · context
    Despite stable fixation, early full weight bearing, and low-intensity pulsed ultrasound therapy, serial radiographs showed minimal progression and absence of bridging callus for more than 8 months. At 9 months after injury, abaloparatide was initiated for a sacral insufficiency fracture associated w…
  3. 03HumanCase report or seriesEfficacy outcome

    In a man who received abaloparatide after delayed tibial healing, sustained union was confirmed at 24 months.

    In plain wordsIn one man who received abaloparatide after delayed tibial healing, the fracture remained united at 24 months.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    Not applicableSustained fracture union
    Study

    n = 1

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Sustained union and full functional recovery were confirmed at 24 months.
    2 context sentences
    Summary · context
    A 59-year-old Japanese man with severe immune thrombocytopenia (platelet count approximately 5000/microL) sustained a Gustilo type III-C open pilon fracture after a crush injury.
    Summary · context
    Despite stable fixation, early full weight bearing, and low-intensity pulsed ultrasound therapy, serial radiographs showed minimal progression and absence of bridging callus for more than 8 months. At 9 months after injury, abaloparatide was initiated for a sacral insufficiency fracture associated w…
  4. 04HumanCase report or seriesEfficacy outcome

    In a man who received abaloparatide after delayed tibial healing, full functional recovery was confirmed at 24 months.

    In plain wordsIn one man who received abaloparatide after delayed tibial healing, full functional recovery was confirmed at 24 months.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    Not applicableFunctional recovery
    Study

    n = 1

    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Sustained union and full functional recovery were confirmed at 24 months.
    2 context sentences
    Summary · context
    A 59-year-old Japanese man with severe immune thrombocytopenia (platelet count approximately 5000/microL) sustained a Gustilo type III-C open pilon fracture after a crush injury.
    Summary · context
    Despite stable fixation, early full weight bearing, and low-intensity pulsed ultrasound therapy, serial radiographs showed minimal progression and absence of bridging callus for more than 8 months. At 9 months after injury, abaloparatide was initiated for a sacral insufficiency fracture associated w…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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