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Study · Measured the body's own peptide · 2026

1 result

Feasibility study examining the short-term effects of Sonic Augmentation Technology™.

Dale LP, Dana AN, Lee CE, Lamont H, Van Vleet Goelz D, Dale CV, Nazarloo P, McIntosh M, Cuffe SP

Frontiers in psychiatry8 Jun 2026

PMID42338740 (opens in a new tab)PMCIDPMC13284157 (opens in a new tab)DOI10.3389/fpsyt.2026.1772405 (opens in a new tab)PepBankPUB-42338740
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Summary

BackgroundThe current study evaluated Sonic Augmentation Technology™ (SAT), a novel, Polyvagal-informed probe that incorporates continuously varying and acoustic features modeled on patterns of autonomic regulation into musical soundscapes. Specifically, the study examined whether SAT led to improvements in self-reported biobehavioral state (e.g. relaxation, breathing slowly, interoceptive clarity), and whether individuals with poorer baseline functioning (i.e., increased autonomic reactivity and anxiety/depression symptoms) reported greater improvements in biobehavioral state following SAT. It also sought to determine whether there would be changes in endogenous oxytocin level, and whether individuals who exhibit larger gains in biobehavioral state would show greater increases in oxytocin.MethodsThe current study examined data obtained from four samples, with 72 participants providing data virtually and 41 participants providing data in-person. Participants completed self-report measures of biobehavioral state, autonomic reactivity, and psychiatric symptomatology (i.e. anxiety and depression). Salivary oxytocin (pg/mL) was assessed via enzyme immunoassay in the participants who completed the study in person, with samples collected pre-and post-SAT.ResultsFollowing SAT, participants reported significant improvements in total biobehavioral state and the low and high arousal subscales. We also found that participants scoring above the cutoff for autonomic reactivity, anxiety, and depression reported greater increases in total biobehavioral state and decreases in the high arousal subscale. Greater decreases in the low arousal subscale were observed in the participants with increased anxiety. The subset of participants with salivary oxytocin samples exhibited increases in salivary oxytocin.ConclusionsThus, our results support the potential of SAT as a low-cost, non-invasive auditory probe for improving wellbeing, especially for clinical populations experiencing autonomic dysregulation and psychiatric difficulties, such as anxiety and depression.Clinical trial registrationClinicalTrials.gov, identifiers NCT06710886, NCT06902506, NCT06580119, and NCT07065227.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialOther

    In adults who completed the study in person, salivary oxytocin levels increased after listening to Sonic Augmentation Technology soundscapes.

    In plain wordsIn adults who heard the sound program, the body's own oxytocin level in saliva went up afterwards.

    Peptide
    Oxytocin
    Outcome
    IncreaseSalivary oxytocin change after Sonic Augmentation Technology
    Study

    n = 41

    Comparator
    Pre-intervention baseline
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    The subset of participants with salivary oxytocin samples exhibited increases in salivary oxytocin.
    2 context sentences
    Summary · context
    The current study examined data obtained from four samples, with 72 participants providing data virtually and 41 participants providing data in-person.
    Summary · context
    Salivary oxytocin (pg/mL) was assessed via enzyme immunoassay in the participants who completed the study in person, with samples collected pre-and post-SAT.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedNot applicableNCT06580119

Somatic Psychoeducational Intervention

University of Floridan = 3015 Oct 2024 to 20 Feb 2025

Work Related Stress

Trial pageClinicalTrials.govUpdated 3 Mar 2025

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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