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Study · Randomized controlled trial · n = 100 · 2026

5 results

Oxytocin Modulates Inhibitory Control via Neural-Temporal Mechanisms.

Yi W, Lin H, Xu X, Fan J, Chen Q, Xin F

Psychophysiology1 Jun 2026

PMID42304973 (opens in a new tab)DOI10.1111/psyp.70342 (opens in a new tab)PepBankPUB-42304973
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy young men, intranasal oxytocin did not significantly affect behavioral performance on an inhibitory control task versus placebo.

    In plain wordsIn healthy young men, oxytocin nose spray did not change task performance compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeBehavioral performance on inhibitory control task
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    OXT did not significantly affect behavioral performance.
    1 context sentence
    Summary · context
    This randomized, double-blind, placebo-controlled pharmacological event-related potential (ERP) study investigated how intranasal OXT (24 IU) influences neural and behavioral correlates of inhibitory control under threat-of-shock (anxiety) and safe conditions in 100 healthy male university students.
  2. 02HumanRandomized controlled trialMechanism

    In healthy young men under threat of shock, intranasal oxytocin reduced P2 amplitude to faces versus placebo.

    In plain wordsIn healthy young men under threat, oxytocin nose spray lowered an early brain-wave response to faces compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseP2 amplitude to faces under threat
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    modulated early perceptual processing of social stimuli under anxiety, as indicated by a reduced P2 amplitude to faces
    1 context sentence
    Summary · context
    This randomized, double-blind, placebo-controlled pharmacological event-related potential (ERP) study investigated how intranasal OXT (24 IU) influences neural and behavioral correlates of inhibitory control under threat-of-shock (anxiety) and safe conditions in 100 healthy male university students.
  3. 03HumanRandomized controlled trialMechanism

    In healthy young men, intranasal oxytocin attenuated the N2 response during the non-social task in an anxiety-dependent way versus placebo.

    In plain wordsIn healthy young men, oxytocin nose spray weakened a conflict-related brain-wave response during the house task when anxious, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseN2 response during non-social task under anxiety
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    influenced conflict-monitoring, as reflected by an anxiety-dependent attenuation of the N2 response during the non-social task
    1 context sentence
    Summary · context
    This randomized, double-blind, placebo-controlled pharmacological event-related potential (ERP) study investigated how intranasal OXT (24 IU) influences neural and behavioral correlates of inhibitory control under threat-of-shock (anxiety) and safe conditions in 100 healthy male university students.
  4. 04HumanRandomized controlled trialMechanism

    In healthy young men, intranasal oxytocin prevented the anxiety-induced increase in the N450 component for houses versus placebo.

    In plain wordsIn healthy young men, oxytocin nose spray blocked a rise in a late brain-wave response to houses under threat, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseN450 response to houses under anxiety
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    OXT prevented the anxiety-induced increase in N450 for houses
    1 context sentence
    Summary · context
    This randomized, double-blind, placebo-controlled pharmacological event-related potential (ERP) study investigated how intranasal OXT (24 IU) influences neural and behavioral correlates of inhibitory control under threat-of-shock (anxiety) and safe conditions in 100 healthy male university students.
  5. 05HumanRandomized controlled trialMechanism

    In healthy young men under threat of shock, intranasal oxytocin enhanced the N450 response to faces versus placebo.

    In plain wordsIn healthy young men under threat, oxytocin nose spray increased a late brain-wave response to faces compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseN450 response to faces under threat
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    enhancing the N450 response to faces under threat.
    1 context sentence
    Summary · context
    This randomized, double-blind, placebo-controlled pharmacological event-related potential (ERP) study investigated how intranasal OXT (24 IU) influences neural and behavioral correlates of inhibitory control under threat-of-shock (anxiety) and safe conditions in 100 healthy male university students.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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