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Study · Systematic review · 2026

3 results

Analgesic effect of oxytocin and its effectiveness in acute pain management: A systematic review.

El Mouaddib H, Nguidi J, Oukfi B, Bahousse FE, Ait Ougjij A

Semergen10 Jun 2026

PMID42269311 (opens in a new tab)DOI10.1016/j.semerg.2026.102788 (opens in a new tab)PepBankPUB-42269311
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In a systematic review of ten studies, several studies reported that oxytocin reduced pain in experimental paradigms such as the cold pressor test.

    In plain wordsIn a review of ten studies, oxytocin reduced pain in several lab pain tests, such as the cold pressor test.

    Peptide
    Oxytocin
    Outcome
    DecreasePain reduction in experimental paradigms (cold pressor test)
    Study

    n: not reported in source

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    several studies reported pain reduction in experimental paradigms such as the cold pressor test.
    1 context sentence
    Summary · context
    Ten studies were included.
  2. 02HumanSystematic reviewEfficacy outcome

    In a systematic review of ten studies, the analgesic effects of oxytocin varied by acute pain context.

    In plain wordsIn a review of ten studies, how well oxytocin eased pain depended on the type of acute pain.

    Peptide
    Oxytocin
    Outcome
    MixedAnalgesic effect across acute pain contexts
    Study

    n: not reported in source

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    OT's analgesic effects varied by acute pain context
    1 context sentence
    Summary · context
    Ten studies were included.
  3. 03HumanSystematic reviewSafety outcome

    In a systematic review of ten studies, reported adverse effects of oxytocin were generally mild.

    In plain wordsIn a review of ten studies, side effects of oxytocin were generally mild.

    Peptide
    Oxytocin
    Outcome
    Not applicableAdverse effects of oxytocin in acute pain studies
    Study

    n: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Reported adverse effects were generally mild, suggesting a favorable safety profile.
    1 context sentence
    Summary · context
    Ten studies were included.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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