DES-mediated self-assembled polypeptides: Synergistic neuromuscular signaling inhibition for anti-aging.

Bai, Wang Z, Liu T, Wang M, Zhang J

Biomaterials advances20 May 2026

PMID42202650DOI10.1016/j.bioadv.2026.214954PepBankPUB-42202650

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Argireline (acetyl hexapeptide-8).

01AnimalNot a test of Argireline (acetyl hexapeptide-8) aloneOther designMechanism
Across unseparated assessments, DAC-SAP/BGP inhibited sodium and calcium channel activity, reduced acetylcholine secretion, and improved skin elasticity and wrinkle parameters.
In plain wordsAcross mixed experiments, the multi-ingredient system reduced nerve signaling measures and improved skin measures.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
MixedNeuromuscular and skin outcomes
Study
n: not reported in source
in vitro, in vivo and exploratory clinical assessments; results not separated
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
In vitro, in vivo, and exploratory clinical assessments demonstrate that DAC-SAP/BGP significantly inhibits sodium and calcium channel activity, reduces acetylcholine (ACh) secretion, and improves skin elasticity and wrinkle parameters.
2 context sentences(design, population, supporting numbers)
Summary · context
Herein, we developed a synergistic transdermal delivery system combining self-assembled tripeptide nanoparticles (DAC-SAPs) and a ternary deep eutectic solvent (DES, betaine-glycerol-propylene glycol, BGP) for anti-aging.
Summary · context
DAC-SAP integrates dipeptide diaminobutyryl benzamide diacetate (DDB), argireline (ARG), and μ-conotoxin (CTX) into a single nanostructure through hydrophobic interactions, hydrogen bonds, and electrostatically driven molecular self-assembly.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4220265004
02Computer modelNot a test of Argireline (acetyl hexapeptide-8) aloneIn silicoMechanism
In molecular simulations, suitable DAC-SAP nanostructure size reduced transmembrane resistance.
In plain wordsComputer simulations suggested that the peptide mixture's nanostructure size reduced resistance to membrane passage.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
DecreaseTransmembrane resistance
Study
n: not reported in source
molecular dynamics simulation of skin permeation
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Molecular dynamics (MD) simulations reveal a dual permeation-promoting mechanism, with an appropriate nanostructure size reducing transmembrane resistance, whereas DES promotes lipid mobility and weakens tight junctions in the stratum corneum (SC).
2 context sentences(design, population, supporting numbers)
Summary · context
Herein, we developed a synergistic transdermal delivery system combining self-assembled tripeptide nanoparticles (DAC-SAPs) and a ternary deep eutectic solvent (DES, betaine-glycerol-propylene glycol, BGP) for anti-aging.
Summary · context
DAC-SAP integrates dipeptide diaminobutyryl benzamide diacetate (DDB), argireline (ARG), and μ-conotoxin (CTX) into a single nanostructure through hydrophobic interactions, hydrogen bonds, and electrostatically driven molecular self-assembly.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4220265001
03Computer modelNot a test of Argireline (acetyl hexapeptide-8) aloneIn silicoMechanism
In molecular simulations of the combined system, DES promoted stratum corneum lipid mobility.
In plain wordsComputer simulations suggested that the mixture's solvent increased skin lipid movement.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseLipid mobility
Study
n: not reported in source
molecular dynamics simulation of stratum corneum
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Molecular dynamics (MD) simulations reveal a dual permeation-promoting mechanism, with an appropriate nanostructure size reducing transmembrane resistance, whereas DES promotes lipid mobility and weakens tight junctions in the stratum corneum (SC).
2 context sentences(design, population, supporting numbers)
Summary · context
Herein, we developed a synergistic transdermal delivery system combining self-assembled tripeptide nanoparticles (DAC-SAPs) and a ternary deep eutectic solvent (DES, betaine-glycerol-propylene glycol, BGP) for anti-aging.
Summary · context
DAC-SAP integrates dipeptide diaminobutyryl benzamide diacetate (DDB), argireline (ARG), and μ-conotoxin (CTX) into a single nanostructure through hydrophobic interactions, hydrogen bonds, and electrostatically driven molecular self-assembly.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4220265002
04Computer modelNot a test of Argireline (acetyl hexapeptide-8) aloneIn silicoMechanism
In molecular simulations of the combined system, DES weakened stratum corneum tight junctions.
In plain wordsComputer simulations suggested that the mixture's solvent weakened skin tight junctions.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
DecreaseTight junction integrity
Study
n: not reported in source
molecular dynamics simulation of stratum corneum
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Molecular dynamics (MD) simulations reveal a dual permeation-promoting mechanism, with an appropriate nanostructure size reducing transmembrane resistance, whereas DES promotes lipid mobility and weakens tight junctions in the stratum corneum (SC).
2 context sentences(design, population, supporting numbers)
Summary · context
Herein, we developed a synergistic transdermal delivery system combining self-assembled tripeptide nanoparticles (DAC-SAPs) and a ternary deep eutectic solvent (DES, betaine-glycerol-propylene glycol, BGP) for anti-aging.
Summary · context
DAC-SAP integrates dipeptide diaminobutyryl benzamide diacetate (DDB), argireline (ARG), and μ-conotoxin (CTX) into a single nanostructure through hydrophobic interactions, hydrogen bonds, and electrostatically driven molecular self-assembly.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4220265003

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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