MOTS-c is associated with oxidative stress and arterial stiffness in peritoneal dialysis patients: a pilot study.

Musolino M, Roumeliotis A, Roumeliotis S, Zicarelli M, Ruosi F, Greco M, Misiti R, Foti DP, Sgouropoulou V, Kocic G, Veljkovic A, Neofytou IE and 6 more

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Alekos I, Papas E, Duni A, Bolignano D, Dounousi E, Liakopoulos V

International urology and nephrology13 May 2026

PMID42126770DOI10.1007/s11255-026-05198-xPepBankPUB-42126770

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In peritoneal dialysis patients, dialysate MOTS‑c was inversely correlated with systolic blood pressure.
In plain wordsIn people on peritoneal dialysis, higher natural MOTS‑c in dialysate fluid was linked to lower systolic blood pressure.
Peptide
MOTS-c
Outcome
Not applicableDialysate MOTS-c and systolic blood pressure
Study
n = 32
Outcome group
Blood pressure · Cardiovascular
Measurements
Correlation R
−0.5
dMOTS-c vs blood pressure
Source sentences
Summary
as well as systolic and diastolic blood pressure (R = -0.5, p < 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
This pilot, clinical study included 32 stable PD patients (mean age 60.7 ± 1.2 years, 62.5% male).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4212677005
02HumanEndogenous levelObservational studyOther
In peritoneal dialysis patients, dialysate MOTS‑c was inversely correlated with diastolic blood pressure.
In plain wordsIn people on peritoneal dialysis, higher natural MOTS‑c in dialysate fluid was linked to lower diastolic blood pressure.
Peptide
MOTS-c
Outcome
Not applicableDialysate MOTS-c and diastolic blood pressure
Study
n = 32
Outcome group
Blood pressure · Cardiovascular
Measurements
Correlation R
−0.5
dMOTS-c vs blood pressure
Source sentences
Summary
as well as systolic and diastolic blood pressure (R = -0.5, p < 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
This pilot, clinical study included 32 stable PD patients (mean age 60.7 ± 1.2 years, 62.5% male).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4212677006
03HumanEndogenous levelObservational studyOther
In peritoneal dialysis patients, urinary MOTS‑c was inversely correlated with serum AOPPs, an oxidative stress marker.
In plain wordsIn people on peritoneal dialysis, higher natural MOTS‑c in urine was linked to lower oxidative stress.
Peptide
MOTS-c
Outcome
Not applicableUrinary MOTS-c and serum AOPPs
Study
n: not reported in source
Outcome group
Aging markers · Kidney and urinary
Measurements
Correlation R
−0.592
uMOTS-c vs AOPPs
Source sentences
Summary
Urinary MOTS-c (uMOTS-c) levels were inversely correlated with serum AOPPs (R = - 0.592, p = 0.012)
1 context sentence(design, population, supporting numbers)
Summary · context
This pilot, clinical study included 32 stable PD patients (mean age 60.7 ± 1.2 years, 62.5% male).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4212677001
04HumanEndogenous levelObservational studyOther
In peritoneal dialysis patients, urinary MOTS‑c was positively associated with pulse wave velocity (arterial stiffness).
In plain wordsIn people on peritoneal dialysis, higher natural MOTS‑c in urine was linked to stiffer arteries.
Peptide
MOTS-c
Outcome
Not applicableUrinary MOTS-c and pulse wave velocity
Study
n: not reported in source
Outcome group
Blood pressure · Cardiovascular
Measurements
Correlation R
0.708
uMOTS-c vs PWV
Source sentences
Summary
and a positive association with PWV (R = 0.708, p = 0.001)
1 context sentence(design, population, supporting numbers)
Summary · context
This pilot, clinical study included 32 stable PD patients (mean age 60.7 ± 1.2 years, 62.5% male).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4212677002
05HumanEndogenous levelObservational studyOther
In peritoneal dialysis patients, urinary MOTS‑c was positively associated with left ventricular systolic function.
In plain wordsIn people on peritoneal dialysis, higher natural MOTS‑c in urine was linked to better heart pumping function.
Peptide
MOTS-c
Outcome
Not applicableUrinary MOTS-c and left ventricular systolic function
Study
n: not reported in source
Outcome group
Heart function · Cardiovascular
Measurements
Correlation R
0.44
uMOTS-c vs LV systolic function
Source sentences
Summary
and left ventricular systolic function (R = 0.440, p = 0.04)
1 context sentence(design, population, supporting numbers)
Summary · context
This pilot, clinical study included 32 stable PD patients (mean age 60.7 ± 1.2 years, 62.5% male).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4212677003
06HumanEndogenous levelObservational studyOther
In peritoneal dialysis patients, dialysate MOTS‑c was strongly and inversely correlated with pulse wave velocity.
In plain wordsIn people on peritoneal dialysis, higher natural MOTS‑c in dialysate fluid was linked to less stiff arteries.
Peptide
MOTS-c
Outcome
Not applicableDialysate MOTS-c and pulse wave velocity
Study
n: not reported in source
Outcome group
Blood pressure · Cardiovascular
Measurements
Correlation R
−0.717
dMOTS-c vs PWV
Source sentences
Summary
Conversely, dialysate MOTS-c (dMOTS-c) were strongly and inversely correlated with PWV (R = - 0.717, p = 0.019)
1 context sentence(design, population, supporting numbers)
Summary · context
This pilot, clinical study included 32 stable PD patients (mean age 60.7 ± 1.2 years, 62.5% male).
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4212677004

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

Keywords

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