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Study · Not a test of the peptide alone · 2026

11 results

Ex Vivo Evaluation of Skin Permeability Enhancement Using TargetCool in Human-Derived Skin Tissue Models.

Yi KH, Kim JH, Heo CY, Seo SB, Kim GH

The Journal of craniofacial surgery5 May 2026

PMID42084412 (opens in a new tab)DOI10.1097/scs.0000000000012829 (opens in a new tab)PepBankPUB-42084412
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone11

In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Argireline (acetyl hexapeptide-8).

  1. 01LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueSafety outcome

    In ex vivo human skin, no structural damage occurred in any acetyl hexapeptide‑8-FITC delivery group.

    In plain wordsIn lab tests with human skin, no delivery group showed structural damage.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    No significant changeTissue structural damage
    Study

    humann: not reported in source

    human-derived facial skin
    Outcome group
    Adverse events · Skin and wound

    Source sentences

    Summary
    No structural damage was observed in any group.
    3 context sentences
    Summary · context
    This study aimed to evaluate the effect of TargetCool on the permeability of Acetyl Hexapeptide-8-FITC in an ex vivo human skin model, comparing its performance alone and in combination with microneedling devices.
    Summary · context
    Facial skin samples from Korean female donors aged 50 to 70 years were prepared into 2 × 2 cm sections and assigned to 6 groups: control (topical application only), Turtle pin 0.5 mm, MTS 1.5 mm, Turtle pin 0.5 mm plus TargetCool, MTS 1.5 mm plus TargetCool, and TargetCool alone.
    Summary · context
    Samples were cultured for 24 hours in a Transwell system following treatment with Acetyl Hexapeptide-8-FITC, then processed for H&E and DAPI staining.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  2. 02LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueActivity measurement

    In ex vivo human skin, Turtle pin increased acetyl hexapeptide‑8-FITC fluorescence intensity by 504% versus topical application.

    In plain wordsIn lab tests, Turtle pin increased peptide fluorescence versus topical application.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreaseFluorescence intensity with Turtle pin
    Study

    humann: not reported in source

    human-derived facial skin
    Comparator
    Topical application only
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Fluorescence increase
    504%
    Turtle pin

    Source sentences

    Summary
    Compared with the control, fluorescence intensity increased by 504% with Turtle pin, 700% with MTS, 1272% with Turtle pin plus TargetCool, 1000% with MTS plus TargetCool, and 492% with TargetCool alone.
    3 context sentences
    Summary · context
    This study aimed to evaluate the effect of TargetCool on the permeability of Acetyl Hexapeptide-8-FITC in an ex vivo human skin model, comparing its performance alone and in combination with microneedling devices.
    Summary · context
    Facial skin samples from Korean female donors aged 50 to 70 years were prepared into 2 × 2 cm sections and assigned to 6 groups: control (topical application only), Turtle pin 0.5 mm, MTS 1.5 mm, Turtle pin 0.5 mm plus TargetCool, MTS 1.5 mm plus TargetCool, and TargetCool alone.
    Summary · context
    Samples were cultured for 24 hours in a Transwell system following treatment with Acetyl Hexapeptide-8-FITC, then processed for H&E and DAPI staining.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  3. 03LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueActivity measurement

    In ex vivo human skin, MTS increased acetyl hexapeptide‑8-FITC fluorescence intensity by 700% versus topical application.

    In plain wordsIn lab tests, MTS increased peptide fluorescence versus topical application.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreaseFluorescence intensity with MTS
    Study

    humann: not reported in source

    human-derived facial skin
    Comparator
    Topical application only
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Fluorescence increase
    700%
    MTS

    Source sentences

    Summary
    Compared with the control, fluorescence intensity increased by 504% with Turtle pin, 700% with MTS, 1272% with Turtle pin plus TargetCool, 1000% with MTS plus TargetCool, and 492% with TargetCool alone.
    3 context sentences
    Summary · context
    This study aimed to evaluate the effect of TargetCool on the permeability of Acetyl Hexapeptide-8-FITC in an ex vivo human skin model, comparing its performance alone and in combination with microneedling devices.
    Summary · context
    Facial skin samples from Korean female donors aged 50 to 70 years were prepared into 2 × 2 cm sections and assigned to 6 groups: control (topical application only), Turtle pin 0.5 mm, MTS 1.5 mm, Turtle pin 0.5 mm plus TargetCool, MTS 1.5 mm plus TargetCool, and TargetCool alone.
    Summary · context
    Samples were cultured for 24 hours in a Transwell system following treatment with Acetyl Hexapeptide-8-FITC, then processed for H&E and DAPI staining.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  4. 04LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueActivity measurement

    In ex vivo human skin, Turtle pin plus TargetCool increased peptide fluorescence intensity by 1272% versus topical application.

    In plain wordsIn lab tests, Turtle pin plus TargetCool increased peptide fluorescence versus topical application.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreaseFluorescence intensity with Turtle pin plus TargetCool
    Study

    humann: not reported in source

    human-derived facial skin
    Comparator
    Topical application only
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Fluorescence increase
    1272%
    Turtle pin plus TargetCool

    Source sentences

    Summary
    Compared with the control, fluorescence intensity increased by 504% with Turtle pin, 700% with MTS, 1272% with Turtle pin plus TargetCool, 1000% with MTS plus TargetCool, and 492% with TargetCool alone.
    3 context sentences
    Summary · context
    This study aimed to evaluate the effect of TargetCool on the permeability of Acetyl Hexapeptide-8-FITC in an ex vivo human skin model, comparing its performance alone and in combination with microneedling devices.
    Summary · context
    Facial skin samples from Korean female donors aged 50 to 70 years were prepared into 2 × 2 cm sections and assigned to 6 groups: control (topical application only), Turtle pin 0.5 mm, MTS 1.5 mm, Turtle pin 0.5 mm plus TargetCool, MTS 1.5 mm plus TargetCool, and TargetCool alone.
    Summary · context
    Samples were cultured for 24 hours in a Transwell system following treatment with Acetyl Hexapeptide-8-FITC, then processed for H&E and DAPI staining.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  5. 05LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueActivity measurement

    In ex vivo human skin, MTS plus TargetCool increased peptide fluorescence intensity by 1000% versus topical application.

    In plain wordsIn lab tests, MTS plus TargetCool increased peptide fluorescence versus topical application.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreaseFluorescence intensity with MTS plus TargetCool
    Study

    humann: not reported in source

    human-derived facial skin
    Comparator
    Topical application only
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Fluorescence increase
    1000%
    MTS plus TargetCool

    Source sentences

    Summary
    Compared with the control, fluorescence intensity increased by 504% with Turtle pin, 700% with MTS, 1272% with Turtle pin plus TargetCool, 1000% with MTS plus TargetCool, and 492% with TargetCool alone.
    3 context sentences
    Summary · context
    This study aimed to evaluate the effect of TargetCool on the permeability of Acetyl Hexapeptide-8-FITC in an ex vivo human skin model, comparing its performance alone and in combination with microneedling devices.
    Summary · context
    Facial skin samples from Korean female donors aged 50 to 70 years were prepared into 2 × 2 cm sections and assigned to 6 groups: control (topical application only), Turtle pin 0.5 mm, MTS 1.5 mm, Turtle pin 0.5 mm plus TargetCool, MTS 1.5 mm plus TargetCool, and TargetCool alone.
    Summary · context
    Samples were cultured for 24 hours in a Transwell system following treatment with Acetyl Hexapeptide-8-FITC, then processed for H&E and DAPI staining.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  6. 06LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueActivity measurement

    In ex vivo human skin, TargetCool alone increased peptide fluorescence intensity by 492% versus topical application.

    In plain wordsIn lab tests, TargetCool increased peptide fluorescence versus topical application.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreaseFluorescence intensity with TargetCool
    Study

    humann: not reported in source

    human-derived facial skin
    Comparator
    Topical application only
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Fluorescence increase
    492%
    TargetCool alone

    Source sentences

    Summary
    Compared with the control, fluorescence intensity increased by 504% with Turtle pin, 700% with MTS, 1272% with Turtle pin plus TargetCool, 1000% with MTS plus TargetCool, and 492% with TargetCool alone.
    3 context sentences
    Summary · context
    This study aimed to evaluate the effect of TargetCool on the permeability of Acetyl Hexapeptide-8-FITC in an ex vivo human skin model, comparing its performance alone and in combination with microneedling devices.
    Summary · context
    Facial skin samples from Korean female donors aged 50 to 70 years were prepared into 2 × 2 cm sections and assigned to 6 groups: control (topical application only), Turtle pin 0.5 mm, MTS 1.5 mm, Turtle pin 0.5 mm plus TargetCool, MTS 1.5 mm plus TargetCool, and TargetCool alone.
    Summary · context
    Samples were cultured for 24 hours in a Transwell system following treatment with Acetyl Hexapeptide-8-FITC, then processed for H&E and DAPI staining.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  7. 07LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueActivity measurement

    In ex vivo human skin, Turtle pin increased peptide penetration depth by 19.01% versus topical application.

    In plain wordsIn lab tests, Turtle pin increased peptide penetration depth versus topical application.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreasePenetration depth with Turtle pin
    Study

    humann: not reported in source

    human-derived facial skin
    Comparator
    Topical application only
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Depth increase
    19.01%
    Turtle pin

    Source sentences

    Summary
    Penetration depth increased by 19.01%, 33.10%, 36.88%, 47.75%, and 35.86%, respectively.
    4 context sentences
    Summary · context
    Compared with the control, fluorescence intensity increased by 504% with Turtle pin, 700% with MTS, 1272% with Turtle pin plus TargetCool, 1000% with MTS plus TargetCool, and 492% with TargetCool alone.
    Summary · context
    This study aimed to evaluate the effect of TargetCool on the permeability of Acetyl Hexapeptide-8-FITC in an ex vivo human skin model, comparing its performance alone and in combination with microneedling devices.
    Summary · context
    Facial skin samples from Korean female donors aged 50 to 70 years were prepared into 2 × 2 cm sections and assigned to 6 groups: control (topical application only), Turtle pin 0.5 mm, MTS 1.5 mm, Turtle pin 0.5 mm plus TargetCool, MTS 1.5 mm plus TargetCool, and TargetCool alone.
    Summary · context
    Samples were cultured for 24 hours in a Transwell system following treatment with Acetyl Hexapeptide-8-FITC, then processed for H&E and DAPI staining.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  8. 08LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueActivity measurement

    In ex vivo human skin, MTS increased peptide penetration depth by 33.10% versus topical application.

    In plain wordsIn lab tests, MTS increased peptide penetration depth versus topical application.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreasePenetration depth with MTS
    Study

    humann: not reported in source

    human-derived facial skin
    Comparator
    Topical application only
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Depth increase
    33.1%
    MTS

    Source sentences

    Summary
    Penetration depth increased by 19.01%, 33.10%, 36.88%, 47.75%, and 35.86%, respectively.
    4 context sentences
    Summary · context
    Compared with the control, fluorescence intensity increased by 504% with Turtle pin, 700% with MTS, 1272% with Turtle pin plus TargetCool, 1000% with MTS plus TargetCool, and 492% with TargetCool alone.
    Summary · context
    This study aimed to evaluate the effect of TargetCool on the permeability of Acetyl Hexapeptide-8-FITC in an ex vivo human skin model, comparing its performance alone and in combination with microneedling devices.
    Summary · context
    Facial skin samples from Korean female donors aged 50 to 70 years were prepared into 2 × 2 cm sections and assigned to 6 groups: control (topical application only), Turtle pin 0.5 mm, MTS 1.5 mm, Turtle pin 0.5 mm plus TargetCool, MTS 1.5 mm plus TargetCool, and TargetCool alone.
    Summary · context
    Samples were cultured for 24 hours in a Transwell system following treatment with Acetyl Hexapeptide-8-FITC, then processed for H&E and DAPI staining.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  9. 09LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueActivity measurement

    In ex vivo human skin, Turtle pin plus TargetCool increased peptide penetration depth by 36.88% versus topical application.

    In plain wordsIn lab tests, Turtle pin plus TargetCool increased peptide penetration depth versus topical application.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreasePenetration depth with Turtle pin plus TargetCool
    Study

    humann: not reported in source

    human-derived facial skin
    Comparator
    Topical application only
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Depth increase
    36.88%
    Turtle pin plus TargetCool

    Source sentences

    Summary
    Penetration depth increased by 19.01%, 33.10%, 36.88%, 47.75%, and 35.86%, respectively.
    4 context sentences
    Summary · context
    Compared with the control, fluorescence intensity increased by 504% with Turtle pin, 700% with MTS, 1272% with Turtle pin plus TargetCool, 1000% with MTS plus TargetCool, and 492% with TargetCool alone.
    Summary · context
    This study aimed to evaluate the effect of TargetCool on the permeability of Acetyl Hexapeptide-8-FITC in an ex vivo human skin model, comparing its performance alone and in combination with microneedling devices.
    Summary · context
    Facial skin samples from Korean female donors aged 50 to 70 years were prepared into 2 × 2 cm sections and assigned to 6 groups: control (topical application only), Turtle pin 0.5 mm, MTS 1.5 mm, Turtle pin 0.5 mm plus TargetCool, MTS 1.5 mm plus TargetCool, and TargetCool alone.
    Summary · context
    Samples were cultured for 24 hours in a Transwell system following treatment with Acetyl Hexapeptide-8-FITC, then processed for H&E and DAPI staining.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  10. 10LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueActivity measurement

    In ex vivo human skin, MTS plus TargetCool increased peptide penetration depth by 47.75% versus topical application.

    In plain wordsIn lab tests, MTS plus TargetCool increased peptide penetration depth versus topical application.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreasePenetration depth with MTS plus TargetCool
    Study

    humann: not reported in source

    human-derived facial skin
    Comparator
    Topical application only
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Depth increase
    47.75%
    MTS plus TargetCool

    Source sentences

    Summary
    Penetration depth increased by 19.01%, 33.10%, 36.88%, 47.75%, and 35.86%, respectively.
    4 context sentences
    Summary · context
    Compared with the control, fluorescence intensity increased by 504% with Turtle pin, 700% with MTS, 1272% with Turtle pin plus TargetCool, 1000% with MTS plus TargetCool, and 492% with TargetCool alone.
    Summary · context
    This study aimed to evaluate the effect of TargetCool on the permeability of Acetyl Hexapeptide-8-FITC in an ex vivo human skin model, comparing its performance alone and in combination with microneedling devices.
    Summary · context
    Facial skin samples from Korean female donors aged 50 to 70 years were prepared into 2 × 2 cm sections and assigned to 6 groups: control (topical application only), Turtle pin 0.5 mm, MTS 1.5 mm, Turtle pin 0.5 mm plus TargetCool, MTS 1.5 mm plus TargetCool, and TargetCool alone.
    Summary · context
    Samples were cultured for 24 hours in a Transwell system following treatment with Acetyl Hexapeptide-8-FITC, then processed for H&E and DAPI staining.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  11. 11LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueActivity measurement

    In ex vivo human skin, TargetCool alone increased peptide penetration depth by 35.86% versus topical application.

    In plain wordsIn lab tests, TargetCool increased peptide penetration depth versus topical application.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreasePenetration depth with TargetCool
    Study

    humann: not reported in source

    human-derived facial skin
    Comparator
    Topical application only
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Depth increase
    35.86%
    TargetCool alone

    Source sentences

    Summary
    Penetration depth increased by 19.01%, 33.10%, 36.88%, 47.75%, and 35.86%, respectively.
    4 context sentences
    Summary · context
    Compared with the control, fluorescence intensity increased by 504% with Turtle pin, 700% with MTS, 1272% with Turtle pin plus TargetCool, 1000% with MTS plus TargetCool, and 492% with TargetCool alone.
    Summary · context
    This study aimed to evaluate the effect of TargetCool on the permeability of Acetyl Hexapeptide-8-FITC in an ex vivo human skin model, comparing its performance alone and in combination with microneedling devices.
    Summary · context
    Facial skin samples from Korean female donors aged 50 to 70 years were prepared into 2 × 2 cm sections and assigned to 6 groups: control (topical application only), Turtle pin 0.5 mm, MTS 1.5 mm, Turtle pin 0.5 mm plus TargetCool, MTS 1.5 mm plus TargetCool, and TargetCool alone.
    Summary · context
    Samples were cultured for 24 hours in a Transwell system following treatment with Acetyl Hexapeptide-8-FITC, then processed for H&E and DAPI staining.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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