The Association Between Serum MOTS-c Levels and Myocardial Ischemia-Reperfusion Injury in Patients with Acute Myocardial Infarction: A Cross-Sectional Study.

Peng L, Li Y, Duan X, Long J, Ran Q, Zeng X, Liu B, Wang D, Yang J

Biomedicines17 Apr 2026

PMID42072458PMCIDPMC13113351DOI10.3390/biomedicines14040918PepBankPUB-42072458

Summary

Background/Objectives: Percutaneous coronary intervention (PCI) effectively restores coronary flow in acute myocardial infarction (AMI), but myocardial ischemia-reperfusion injury (MIRI) remains a major prognostic determinant. Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) has shown cardiovascular protective effects, yet its association with MIRI is unclear. This study aimed to investigate the relationship between serum MOTS-c levels and MIRI in AMI patients. Methods: Seventy-two AMI patients undergoing PCI were enrolled and divided into MIRI (n = 34) and non-MIRI (n = 38) groups. Clinical data and MOTS-c levels in peripheral serum and intracoronary blood were compared. Multivariate logistic regression and receiver operating characteristic (ROC) analysis were performed to identify MIRI predictors. Results: The MIRI group exhibited lower systolic blood pressure, preoperative thrombolysis in myocardial infarction (TIMI) grade, and HDL-C, but higher total ischemic time, door-to-balloon time, culprit vessel stenosis severity, Killip grade and adverse event incidence (all p < 0.05). Postoperative peripheral serum MOTS-c levels were significantly lower in the MIRI group than in the non-MIRI group (p < 0.05), while preoperative peripheral and intracoronary MOTS-c levels showed no significant differences between groups. Multivariate logistic regression identified postoperative peripheral MOTS-c levels (OR = 0.986, 95%CI: 0.976-0.996) and preoperative TIMI grade ≥ 1 (OR = 0.036, 95%CI: 0.004-0.309) as independent protective factors for MIRI, whereas serum creatinine was identified as an independent risk factor. ROC analysis demonstrated that postoperative peripheral MOTS-c levels predicted MIRI with an area under the curve of 0.648. Conclusions: Postoperative peripheral serum MOTS-c levels represent an independent protective factor against MIRI in patients with acute myocardial infarction and suggest a potential predictive value for MIRI, although its clinical utility as a standalone predictor requires further validation through dynamic monitoring and larger-scale studies. This finding may offer a potential novel biomarker and therapeutic direction for MIRI.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In patients with acute myocardial infarction undergoing PCI, postoperative peripheral serum levels of the body's own MOTS‑c were lower in those with ischemia-reperfusion injury than in those without.
In plain wordsAfter a heart attack procedure, patients with reperfusion injury had lower levels of the body's own MOTS‑c in the blood than patients without it.
Peptide
MOTS-c
Outcome
DecreasePostoperative peripheral serum MOTS-c in MIRI versus non-MIRI
Study
n = 72
Comparator
Non-MIRI group
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
Postoperative peripheral serum MOTS-c levels were significantly lower in the MIRI group than in the non-MIRI group (p < 0.05)
1 context sentence(design, population, supporting numbers)
Summary · context
Seventy-two AMI patients undergoing PCI were enrolled and divided into MIRI (n = 34) and non-MIRI (n = 38) groups.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-4207245801
02HumanEndogenous levelObservational studyOther
Preoperative peripheral and intracoronary levels of the body's own MOTS‑c did not differ between the MIRI and non-MIRI groups.
In plain wordsBefore the procedure, the body's own MOTS‑c levels did not differ between patients who later had reperfusion injury and those who did not.
Peptide
MOTS-c
Outcome
No significant changePreoperative peripheral and intracoronary MOTS-c in MIRI versus non-MIRI
Study
n = 72
Comparator
Non-MIRI group
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
while preoperative peripheral and intracoronary MOTS-c levels showed no significant differences between groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Seventy-two AMI patients undergoing PCI were enrolled and divided into MIRI (n = 34) and non-MIRI (n = 38) groups.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-4207245802
03HumanEndogenous levelObservational studyOther
In multivariate logistic regression, higher postoperative peripheral MOTS‑c levels were an independent protective factor against MIRI.
In plain wordsHigher body's own MOTS‑c levels after the procedure were linked to a lower chance of reperfusion injury.
Peptide
MOTS-c
Outcome
DecreasePostoperative MOTS-c as independent protective factor for MIRI
Study
n = 72
Outcome group
Mitochondrial function · Cardiovascular
Measurements
Odds ratio
0.986
postoperative peripheral MOTS-c
Source sentences
Summary
Multivariate logistic regression identified postoperative peripheral MOTS-c levels (OR = 0.986, 95%CI: 0.976-0.996)
1 context sentence(design, population, supporting numbers)
Summary · context
Seventy-two AMI patients undergoing PCI were enrolled and divided into MIRI (n = 34) and non-MIRI (n = 38) groups.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-4207245803
04HumanEndogenous levelObservational studyOther
Postoperative peripheral MOTS‑c levels predicted MIRI with an area under the ROC curve of 0.648.
In plain wordsAfter the procedure, the body's own MOTS‑c level predicted reperfusion injury with an area under the curve of 0.648.
Peptide
MOTS-c
Outcome
Not applicablePrediction of MIRI by postoperative MOTS-c (ROC AUC)
Study
n = 72
Outcome group
Mitochondrial function · Cardiovascular
Measurements
AUC
0.648
postoperative peripheral MOTS-c
Source sentences
Summary
ROC analysis demonstrated that postoperative peripheral MOTS-c levels predicted MIRI with an area under the curve of 0.648.
1 context sentence(design, population, supporting numbers)
Summary · context
Seventy-two AMI patients undergoing PCI were enrolled and divided into MIRI (n = 34) and non-MIRI (n = 38) groups.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-4207245804

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.