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Study · Not a test of the peptide alone · 2026

4 results

Microenvironment-responsive injectable dynamic hydrogel for sequential antioxidant and tissue regeneration therapy of radiation-induced skin injury.

Yu X, Yang T, Bei Z, Liu J, Song Y, Wang Q, Li J, Liang S, Qian Z

Bioactive materials21 Apr 2026

PMID42058630 (opens in a new tab)PMCIDPMC13123401 (opens in a new tab)DOI10.1016/j.bioactmat.2026.03.057 (opens in a new tab)PepBankPUB-42058630
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK-Cu.

  1. 01AnimalNot a test of GHK-Cu aloneOther designEfficacy outcome

    The HCG@CDs hydrogel significantly accelerated the healing of radiation-induced skin wounds.

    In plain wordsIn tests, a hydrogel with carbon dots and GHK‑Cu sped up healing of radiation skin wounds.

    Peptide
    GHK-Cu
    Outcome
    IncreaseHealing of radiation-induced skin wounds
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    In vitro and in vivo evaluations have confirmed that the HCG@CDs hydrogel effectively alleviates radiation-induced oxidative damage and inflammatory responses, significantly accelerating the healing of skin wounds.
    1 context sentence
    Summary · context
    To overcome this limitation, we have developed a multifunctional injectable hydrogel, HCG@CDs, by cross-linking biocompatible carboxymethyl chitosan (CMCS) with oxidized hyaluronic acid (OHA) conjugated to the Glycyl-L-Histidyl-L-Lysine-Copper(II) complex (GHK-Cu 2+ ) via dynamic Schiff-base linkages.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  2. 02LabNot a test of GHK-Cu aloneIn vitro (cell-free)Pharmacokinetics

    The HCG@CDs hydrogel released carbon dots rapidly in an acidic wound microenvironment and then released GHK‑Cu 2+ in a sustained manner.

    In plain wordsIn lab tests, the hydrogel released carbon dots quickly in acid conditions and then released GHK‑Cu slowly.

    Peptide
    GHK-Cu
    Outcome
    Not applicablepH-responsive release of carbon dots and sustained release of GHK-Cu 2+
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The system exhibits intelligent, pH-responsive release behavior, whereby CDs are rapidly liberated in the acidic wound microenvironment to efficiently scavenge ROS and mitigate early-stage oxidative stress.
    2 context sentences
    Summary · context
    Subsequently, GHK-Cu 2+ is released in a sustained manner
    Summary · context
    To overcome this limitation, we have developed a multifunctional injectable hydrogel, HCG@CDs, by cross-linking biocompatible carboxymethyl chitosan (CMCS) with oxidized hyaluronic acid (OHA) conjugated to the Glycyl-L-Histidyl-L-Lysine-Copper(II) complex (GHK-Cu 2+ ) via dynamic Schiff-base linkages.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  3. 03LabNot a test of GHK-Cu aloneOther designEfficacy outcome

    In vitro and in vivo evaluations confirmed that the HCG@CDs hydrogel alleviates radiation-induced oxidative damage.

    In plain wordsIn tests, a hydrogel with carbon dots and GHK‑Cu reduced oxidative damage from radiation.

    Peptide
    GHK-Cu
    Outcome
    DecreaseRadiation-induced oxidative damage
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Skin and wound

    Source sentences

    Summary
    In vitro and in vivo evaluations have confirmed that the HCG@CDs hydrogel effectively alleviates radiation-induced oxidative damage and inflammatory responses, significantly accelerating the healing of skin wounds.
    1 context sentence
    Summary · context
    To overcome this limitation, we have developed a multifunctional injectable hydrogel, HCG@CDs, by cross-linking biocompatible carboxymethyl chitosan (CMCS) with oxidized hyaluronic acid (OHA) conjugated to the Glycyl-L-Histidyl-L-Lysine-Copper(II) complex (GHK-Cu 2+ ) via dynamic Schiff-base linkages.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  4. 04LabNot a test of GHK-Cu aloneOther designEfficacy outcome

    In vitro and in vivo evaluations confirmed that the HCG@CDs hydrogel alleviates radiation-induced inflammatory responses.

    In plain wordsIn tests, a hydrogel with carbon dots and GHK‑Cu reduced inflammation from radiation.

    Peptide
    GHK-Cu
    Outcome
    DecreaseRadiation-induced inflammatory responses
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Skin and wound

    Source sentences

    Summary
    In vitro and in vivo evaluations have confirmed that the HCG@CDs hydrogel effectively alleviates radiation-induced oxidative damage and inflammatory responses, significantly accelerating the healing of skin wounds.
    1 context sentence
    Summary · context
    To overcome this limitation, we have developed a multifunctional injectable hydrogel, HCG@CDs, by cross-linking biocompatible carboxymethyl chitosan (CMCS) with oxidized hyaluronic acid (OHA) conjugated to the Glycyl-L-Histidyl-L-Lysine-Copper(II) complex (GHK-Cu 2+ ) via dynamic Schiff-base linkages.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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