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Study · Animal study (in vivo) · mouse · 2026

2 results

Potassium-Competitive Acid Blocker Increases Ileal Permeability and Exacerbates Ileal Inflammation under Stress Conditions in a Mouse Model of Eosinophilic Enteritis.

Yamamoto K, Tanaka F, Nishida Y, Maruyama H, Ominami M, Nadatani Y, Otani K, Fukunaga S, Hosomi S, Fujiwara Y

Digestion20 Apr 2026

PMID42008374 (opens in a new tab)DOI10.1159/000552062 (opens in a new tab)PepBankPUB-42008374
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In stressed P-CAB-treated EoN mice, larazotide acetate improved ileal inflammation.

    In plain wordsIn mice with stressed, P-CAB-treated enteritis, larazotide reduced ileal inflammation.

    Peptide
    Larazotide
    Outcome
    DecreaseIleal inflammation
    Study

    mousen: not reported in source

    water avoidance stress and P-CAB-treated eosinophilic enteritis mice
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Larazotide acetate, a zonulin inhibitor, significantly improved ileal inflammation and decreased ileal permeability in the WAS + P-CAB-treated EoN mice.
    1 context sentence
    Summary · context
    An EoN model was established in BALB/c mice using ovalbumin (OVA) sensitization and challenge.
  2. 02LabEx vivo tissueEfficacy outcome

    In stressed P-CAB-treated EoN mice, larazotide acetate decreased ileal permeability.

    In plain wordsIn lab tests, ileal tissue from stressed, P-CAB-treated mice had lower permeability after larazotide treatment.

    Peptide
    Larazotide
    Outcome
    DecreaseIleal permeability
    Study

    mousen: not reported in source

    ileal tissue from water avoidance stress and P-CAB-treated eosinophilic enteritis mice in a Ussing chamber
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Larazotide acetate, a zonulin inhibitor, significantly improved ileal inflammation and decreased ileal permeability in the WAS + P-CAB-treated EoN mice.
    2 context sentences
    Summary · context
    The ileum was collected for the analysis of ileal microscopic inflammation, mRNA and protein expression levels of T helper type 2 (Th2) cytokines, and ex vivo ileal permeability using a Ussing chamber.
    Summary · context
    An EoN model was established in BALB/c mice using ovalbumin (OVA) sensitization and challenge.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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