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Study · Animal study (in vivo) · zebrafish · 2026

10 results

Glycyl-L-histidyl-L-lysine-Cu2+ (GHK-Cu) Attenuates CuSO4 or LPS induced-inflammation in Zebrafish larvae model.

Hu J, Zhang C, Wang F

European journal of pharmacology15 Apr 2026

PMID41997403 (opens in a new tab)DOI10.1016/j.ejphar.2026.178880 (opens in a new tab)PepBankPUB-41997403
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In zebrafish larvae with CuSO4- or LPS-induced inflammation, GHK‑Cu decreased neutrophil migration.

    In plain wordsIn zebrafish larvae, GHK‑Cu reduced the movement of neutrophils, a type of white blood cell, to inflamed sites.

    Peptide
    GHK-Cu
    Outcome
    DecreaseNeutrophil migration
    Study

    zebrafishn: not reported in source

    Zebrafish larvae with acute inflammation induced by CuSO4 or LPS
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHK-Cu notably decreased the migration of neutrophils and macrophages
    1 context sentence
    Summary · context
    In this study, we explored the anti-inflammatory effects of GHK-Cu against the acute inflammation induced by copper sulfate (CuSO4) and lipopolysaccharide (LPS) in zebrafish larvae.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In zebrafish larvae with CuSO4- or LPS-induced inflammation, GHK‑Cu decreased macrophage migration.

    In plain wordsIn zebrafish larvae, GHK‑Cu reduced the movement of macrophages, a type of white blood cell, to inflamed sites.

    Peptide
    GHK-Cu
    Outcome
    DecreaseMacrophage migration
    Study

    zebrafishn: not reported in source

    Zebrafish larvae with acute inflammation induced by CuSO4 or LPS
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHK-Cu notably decreased the migration of neutrophils and macrophages
    1 context sentence
    Summary · context
    In this study, we explored the anti-inflammatory effects of GHK-Cu against the acute inflammation induced by copper sulfate (CuSO4) and lipopolysaccharide (LPS) in zebrafish larvae.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In zebrafish larvae with CuSO4- or LPS-induced inflammation, GHK‑Cu suppressed expression of the pro-inflammatory cytokine tnf-a.

    In plain wordsIn zebrafish larvae, GHK‑Cu lowered the activity of the inflammation signal gene tnf-a.

    Peptide
    GHK-Cu
    Outcome
    Decreasetnf-a expression
    Study

    zebrafishn: not reported in source

    Zebrafish larvae with acute inflammation induced by CuSO4 or LPS
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHK-Cu notably decreased the migration of neutrophils and macrophages, suppressed the expression of pro-inflammatory cytokines (tnf-a, il-1β, il6) and increased the expression of the anti-inflammatory cytokine il-10.
    1 context sentence
    Summary · context
    In this study, we explored the anti-inflammatory effects of GHK-Cu against the acute inflammation induced by copper sulfate (CuSO4) and lipopolysaccharide (LPS) in zebrafish larvae.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In zebrafish larvae with CuSO4- or LPS-induced inflammation, GHK‑Cu suppressed expression of the pro-inflammatory cytokine il-1β.

    In plain wordsIn zebrafish larvae, GHK‑Cu lowered the activity of the inflammation signal gene il-1β.

    Peptide
    GHK-Cu
    Outcome
    Decreaseil-1β expression
    Study

    zebrafishn: not reported in source

    Zebrafish larvae with acute inflammation induced by CuSO4 or LPS
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHK-Cu notably decreased the migration of neutrophils and macrophages, suppressed the expression of pro-inflammatory cytokines (tnf-a, il-1β, il6) and increased the expression of the anti-inflammatory cytokine il-10.
    1 context sentence
    Summary · context
    In this study, we explored the anti-inflammatory effects of GHK-Cu against the acute inflammation induced by copper sulfate (CuSO4) and lipopolysaccharide (LPS) in zebrafish larvae.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In zebrafish larvae with CuSO4- or LPS-induced inflammation, GHK‑Cu suppressed expression of the pro-inflammatory cytokine il6.

    In plain wordsIn zebrafish larvae, GHK‑Cu lowered the activity of the inflammation signal gene il6.

    Peptide
    GHK-Cu
    Outcome
    Decreaseil6 expression
    Study

    zebrafishn: not reported in source

    Zebrafish larvae with acute inflammation induced by CuSO4 or LPS
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHK-Cu notably decreased the migration of neutrophils and macrophages, suppressed the expression of pro-inflammatory cytokines (tnf-a, il-1β, il6) and increased the expression of the anti-inflammatory cytokine il-10.
    1 context sentence
    Summary · context
    In this study, we explored the anti-inflammatory effects of GHK-Cu against the acute inflammation induced by copper sulfate (CuSO4) and lipopolysaccharide (LPS) in zebrafish larvae.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In zebrafish larvae with CuSO4- or LPS-induced inflammation, GHK‑Cu increased expression of the anti-inflammatory cytokine il-10.

    In plain wordsIn zebrafish larvae, GHK‑Cu raised the activity of the anti-inflammation signal gene il-10.

    Peptide
    GHK-Cu
    Outcome
    Increaseil-10 expression
    Study

    zebrafishn: not reported in source

    Zebrafish larvae with acute inflammation induced by CuSO4 or LPS
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHK-Cu notably decreased the migration of neutrophils and macrophages, suppressed the expression of pro-inflammatory cytokines (tnf-a, il-1β, il6) and increased the expression of the anti-inflammatory cytokine il-10.
    1 context sentence
    Summary · context
    In this study, we explored the anti-inflammatory effects of GHK-Cu against the acute inflammation induced by copper sulfate (CuSO4) and lipopolysaccharide (LPS) in zebrafish larvae.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In zebrafish larvae with CuSO4- or LPS-induced inflammation, GHK‑Cu reduced nitric oxide (NO) levels.

    In plain wordsIn zebrafish larvae, GHK‑Cu lowered nitric oxide, a marker of oxidative stress.

    Peptide
    GHK-Cu
    Outcome
    DecreaseNitric oxide level
    Study

    zebrafishn: not reported in source

    Zebrafish larvae with acute inflammation induced by CuSO4 or LPS
    Outcome group
    Oxidative stress · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, GHK-Cu mitigated oxidative stress by reducing levels of nitric oxide (NO) and reactive oxygen species (ROS), and improved superoxide dismutase (SOD) activity.
    1 context sentence
    Summary · context
    In this study, we explored the anti-inflammatory effects of GHK-Cu against the acute inflammation induced by copper sulfate (CuSO4) and lipopolysaccharide (LPS) in zebrafish larvae.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In zebrafish larvae with CuSO4- or LPS-induced inflammation, GHK‑Cu reduced reactive oxygen species (ROS) levels.

    In plain wordsIn zebrafish larvae, GHK‑Cu lowered reactive oxygen species, a marker of oxidative stress.

    Peptide
    GHK-Cu
    Outcome
    DecreaseReactive oxygen species level
    Study

    zebrafishn: not reported in source

    Zebrafish larvae with acute inflammation induced by CuSO4 or LPS
    Outcome group
    Oxidative stress · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, GHK-Cu mitigated oxidative stress by reducing levels of nitric oxide (NO) and reactive oxygen species (ROS), and improved superoxide dismutase (SOD) activity.
    1 context sentence
    Summary · context
    In this study, we explored the anti-inflammatory effects of GHK-Cu against the acute inflammation induced by copper sulfate (CuSO4) and lipopolysaccharide (LPS) in zebrafish larvae.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In zebrafish larvae with CuSO4- or LPS-induced inflammation, GHK‑Cu improved superoxide dismutase (SOD) activity.

    In plain wordsIn zebrafish larvae, GHK‑Cu raised the activity of SOD, an antioxidant enzyme.

    Peptide
    GHK-Cu
    Outcome
    IncreaseSuperoxide dismutase activity
    Study

    zebrafishn: not reported in source

    Zebrafish larvae with acute inflammation induced by CuSO4 or LPS
    Outcome group
    Oxidative stress · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, GHK-Cu mitigated oxidative stress by reducing levels of nitric oxide (NO) and reactive oxygen species (ROS), and improved superoxide dismutase (SOD) activity.
    1 context sentence
    Summary · context
    In this study, we explored the anti-inflammatory effects of GHK-Cu against the acute inflammation induced by copper sulfate (CuSO4) and lipopolysaccharide (LPS) in zebrafish larvae.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In zebrafish larvae, GHK‑Cu administration downregulated the JAK1 pathway.

    In plain wordsIn zebrafish larvae, GHK‑Cu turned down the JAK1 signalling pathway.

    Peptide
    GHK-Cu
    Outcome
    DecreaseJAK1 pathway
    Study

    zebrafishn: not reported in source

    Zebrafish larvae with acute inflammation induced by CuSO4 or LPS
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, pathway analysis revealed that GHK-Cu administration downregulated the JAK1 pathway.
    1 context sentence
    Summary · context
    In this study, we explored the anti-inflammatory effects of GHK-Cu against the acute inflammation induced by copper sulfate (CuSO4) and lipopolysaccharide (LPS) in zebrafish larvae.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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