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Study · Animal study (in vivo) · mouse · 2026

25 results

[AMP-activated protein kinase activation alleviates lipopolysaccharide-induced sepsis-associated acute kidney injury by inhibiting ferroptosis].

Wang M, Kang Y, Zhang B, Zhang C, Li F, Jiang X, Li J, Chang D

Zhonghua wei zhong bing ji jiu yi xue1 Mar 2026

PMID41958127 (opens in a new tab)DOI10.3760/cma.j.cn121430-20250303-00123 (opens in a new tab)PepBankPUB-41958127
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study25

25 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR reduced renal tubular structural damage versus LPS alone.

    In plain wordsIn mice, AICAR reduced kidney tubule damage compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseRenal tubular structural damage
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In contrast to the LPS group, mice in the LPS+AICAR group displayed significant alleviation of renal tubular structural damage and vacuolar degeneration, as well as reduced interstitial edema and inflammatory infiltration.
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR reduced renal vacuolar degeneration versus LPS alone.

    In plain wordsIn mice, AICAR reduced kidney vacuolar degeneration compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseVacuolar degeneration
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In contrast to the LPS group, mice in the LPS+AICAR group displayed significant alleviation of renal tubular structural damage and vacuolar degeneration, as well as reduced interstitial edema and inflammatory infiltration.
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR reduced renal interstitial edema versus LPS alone.

    In plain wordsIn mice, AICAR reduced kidney interstitial swelling compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseInterstitial edema
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In contrast to the LPS group, mice in the LPS+AICAR group displayed significant alleviation of renal tubular structural damage and vacuolar degeneration, as well as reduced interstitial edema and inflammatory infiltration.
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR reduced renal inflammatory infiltration versus LPS alone.

    In plain wordsIn mice, AICAR reduced kidney inflammatory infiltration compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseInflammatory infiltration
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In contrast to the LPS group, mice in the LPS+AICAR group displayed significant alleviation of renal tubular structural damage and vacuolar degeneration, as well as reduced interstitial edema and inflammatory infiltration.
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR ameliorated ferroptosis-related renal mitochondrial ultrastructural changes.

    In plain wordsIn mice, AICAR reduced kidney mitochondrial damage compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMitochondrial ultrastructure
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The ferroptosis-related ultrastructural changes in renal mitochondria were also notably ameliorated.
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR lowered serum IL-1β versus LPS alone.

    In plain wordsIn mice, AICAR lowered serum IL-1β compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseSerum IL-1β
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    IL-1β
    68.93 ng/L
    LPS+AICAR
    IL-1β
    91.25 ng/L
    LPS

    Source sentences

    Summary
    The serum concentrations of IL-1β, IL-6, TNF-α, SCr, and BUN were significantly lower in the LPS+AICAR group than in the LPS group [IL-1β (ng/L): 68.93±9.37 vs. 91.25±10.55, IL-6 (ng/L): 80.03±7.86 vs. 93.10±6.16, TNF-α (ng/L): 484.77±51.00 vs. 558.59±48.54, SCr (μmol/L): 31.75±5.08 vs. 57.63±6.37,…
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR lowered serum IL-6 versus LPS alone.

    In plain wordsIn mice, AICAR lowered serum IL-6 compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseSerum IL-6
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    IL-6
    80.03 ng/L
    LPS+AICAR
    IL-6
    93.1 ng/L
    LPS

    Source sentences

    Summary
    The serum concentrations of IL-1β, IL-6, TNF-α, SCr, and BUN were significantly lower in the LPS+AICAR group than in the LPS group [IL-1β (ng/L): 68.93±9.37 vs. 91.25±10.55, IL-6 (ng/L): 80.03±7.86 vs. 93.10±6.16, TNF-α (ng/L): 484.77±51.00 vs. 558.59±48.54, SCr (μmol/L): 31.75±5.08 vs. 57.63±6.37,…
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR lowered serum TNF-α versus LPS alone.

    In plain wordsIn mice, AICAR lowered serum TNF-α compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseSerum TNF-α
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    TNF-α
    484.77 ng/L
    LPS+AICAR
    TNF-α
    558.59 ng/L
    LPS

    Source sentences

    Summary
    The serum concentrations of IL-1β, IL-6, TNF-α, SCr, and BUN were significantly lower in the LPS+AICAR group than in the LPS group [IL-1β (ng/L): 68.93±9.37 vs. 91.25±10.55, IL-6 (ng/L): 80.03±7.86 vs. 93.10±6.16, TNF-α (ng/L): 484.77±51.00 vs. 558.59±48.54, SCr (μmol/L): 31.75±5.08 vs. 57.63±6.37,…
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR lowered serum creatinine versus LPS alone.

    In plain wordsIn mice, AICAR lowered serum creatinine compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseSerum creatinine
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    SCr
    31.75 μmol/L
    LPS+AICAR
    SCr
    57.63 μmol/L
    LPS

    Source sentences

    Summary
    The serum concentrations of IL-1β, IL-6, TNF-α, SCr, and BUN were significantly lower in the LPS+AICAR group than in the LPS group [IL-1β (ng/L): 68.93±9.37 vs. 91.25±10.55, IL-6 (ng/L): 80.03±7.86 vs. 93.10±6.16, TNF-α (ng/L): 484.77±51.00 vs. 558.59±48.54, SCr (μmol/L): 31.75±5.08 vs. 57.63±6.37,…
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR lowered blood urea nitrogen versus LPS alone.

    In plain wordsIn mice, AICAR lowered blood urea nitrogen compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseBlood urea nitrogen
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    BUN
    23.93 mmol/L
    LPS+AICAR
    BUN
    36.35 mmol/L
    LPS

    Source sentences

    Summary
    The serum concentrations of IL-1β, IL-6, TNF-α, SCr, and BUN were significantly lower in the LPS+AICAR group than in the LPS group [IL-1β (ng/L): 68.93±9.37 vs. 91.25±10.55, IL-6 (ng/L): 80.03±7.86 vs. 93.10±6.16, TNF-α (ng/L): 484.77±51.00 vs. 558.59±48.54, SCr (μmol/L): 31.75±5.08 vs. 57.63±6.37,…
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR lowered renal iron versus LPS alone.

    In plain wordsIn mice, AICAR lowered kidney iron compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseRenal iron
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    Fe2+
    4.02 μmol/g
    LPS+AICAR
    Fe2+
    6.84 μmol/g
    LPS

    Source sentences

    Summary
    Additionally, the levels of Fe2+ and MDA in renal tissues were significantly reduced in the LPS+AICAR group compared with the LPS group [Fe2+ (μmol/g): 4.02±0.74 vs. 6.84±1.41, MDA (μmol/g): 1.44±0.62 vs. 2.62±0.62, both P<0.05]
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR lowered renal MDA versus LPS alone.

    In plain wordsIn mice, AICAR lowered kidney MDA compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseRenal MDA
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    MDA
    1.44 μmol/g
    LPS+AICAR
    MDA
    2.62 μmol/g
    LPS

    Source sentences

    Summary
    Additionally, the levels of Fe2+ and MDA in renal tissues were significantly reduced in the LPS+AICAR group compared with the LPS group [Fe2+ (μmol/g): 4.02±0.74 vs. 6.84±1.41, MDA (μmol/g): 1.44±0.62 vs. 2.62±0.62, both P<0.05]
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR lowered renal ACSL4 mRNA versus LPS alone.

    In plain wordsIn mice, AICAR lowered kidney ACSL4 mRNA compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseACSL4 mRNA
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    ACSL4 mRNA
    1.98 relative expression
    LPS+AICAR
    ACSL4 mRNA
    3.67 relative expression
    LPS

    Source sentences

    Summary
    accompanied by downregulated mRNA and protein expression of ACSL4 (ACSL4 mRNA: 1.98±0.50 vs. 3.67±0.80, ACSL4/GAPDH: 0.49±0.08 vs. 0.94±0.12, both P<0.05).
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR lowered renal ACSL4 protein versus LPS alone.

    In plain wordsIn mice, AICAR lowered kidney ACSL4 protein compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseACSL4 protein
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    ACSL4/GAPDH
    0.49 ratio
    LPS+AICAR
    ACSL4/GAPDH
    0.94 ratio
    LPS

    Source sentences

    Summary
    accompanied by downregulated mRNA and protein expression of ACSL4 (ACSL4 mRNA: 1.98±0.50 vs. 3.67±0.80, ACSL4/GAPDH: 0.49±0.08 vs. 0.94±0.12, both P<0.05).
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  15. 15AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR increased renal GSH versus LPS alone.

    In plain wordsIn mice, AICAR increased kidney GSH compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseRenal GSH
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    GSH
    4.35 μmol/kg
    LPS+AICAR
    GSH
    3.49 μmol/kg
    LPS

    Source sentences

    Summary
    Furthermore, the renal GSH level was higher in the LPS+AICAR group than in the LPS group (μmol/kg: 4.35±0.50 vs. 3.49±0.94)
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  16. 16AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR increased renal AMPK mRNA versus LPS alone.

    In plain wordsIn mice, AICAR increased kidney AMPK mRNA compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK mRNA
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    AMPK mRNA
    2.68 relative expression
    LPS+AICAR
    AMPK mRNA
    1.22 relative expression
    LPS

    Source sentences

    Summary
    AMPK mRNA (2-ΔΔCt): 2.68±0.27 vs. 1.22±0.24
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  17. 17AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR increased renal SLC7A11 mRNA versus LPS alone.

    In plain wordsIn mice, AICAR increased kidney SLC7A11 mRNA compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSLC7A11 mRNA
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    SLC7A11 mRNA
    0.04 relative expression
    LPS+AICAR
    SLC7A11 mRNA
    0.01 relative expression
    LPS

    Source sentences

    Summary
    SLC7A11 mRNA (2-ΔΔCt): 0.04±0.01 vs. 0.01±0.00
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  18. 18AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR increased renal GPX4 mRNA versus LPS alone.

    In plain wordsIn mice, AICAR increased kidney GPX4 mRNA compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseGPX4 mRNA
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    GPX4 mRNA
    5.15 relative expression
    LPS+AICAR
    GPX4 mRNA
    3.4 relative expression
    LPS

    Source sentences

    Summary
    GPX4 mRNA (2-ΔΔCt): 5.15±1.21 vs. 3.40±0.45
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  19. 19AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR increased renal Nrf2 mRNA versus LPS alone.

    In plain wordsIn mice, AICAR increased kidney Nrf2 mRNA compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseNrf2 mRNA
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    Nrf2 mRNA
    0.57 relative expression
    LPS+AICAR
    Nrf2 mRNA
    0.22 relative expression
    LPS

    Source sentences

    Summary
    Nrf2 mRNA (2-ΔΔCt): 0.57±0.29 vs. 0.22±0.23
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  20. 20AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR increased renal HO-1 mRNA versus LPS alone.

    In plain wordsIn mice, AICAR increased kidney HO-1 mRNA compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseHO-1 mRNA
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    HO-1 mRNA
    0.12 relative expression
    LPS+AICAR
    HO-1 mRNA
    0.02 relative expression
    LPS

    Source sentences

    Summary
    HO-1 mRNA (2-ΔΔCt): 0.12±0.03 vs. 0.02±0.01
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  21. 21AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR increased the renal p-AMPK/AMPK ratio versus LPS alone.

    In plain wordsIn mice, AICAR increased the kidney p-AMPK/AMPK ratio compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    Increasep-AMPK/AMPK
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    p-AMPK/AMPK
    1.19 ratio
    LPS+AICAR
    p-AMPK/AMPK
    0.5 ratio
    LPS

    Source sentences

    Summary
    protein expression: p-AMPK/AMPK ratio: 1.19±0.14 vs. 0.50±0.15
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  22. 22AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR increased renal SLC7A11 protein versus LPS alone.

    In plain wordsIn mice, AICAR increased kidney SLC7A11 protein compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSLC7A11 protein
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    SLC7A11/GAPDH
    0.55 ratio
    LPS+AICAR
    SLC7A11/GAPDH
    0.34 ratio
    LPS

    Source sentences

    Summary
    SLC7A11/GAPDH: 0.55±0.07 vs. 0.34±0.10
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  23. 23AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR increased renal GPX4 protein versus LPS alone.

    In plain wordsIn mice, AICAR increased kidney GPX4 protein compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseGPX4 protein
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    GPX4/GAPDH
    0.56 ratio
    LPS+AICAR
    GPX4/GAPDH
    0.18 ratio
    LPS

    Source sentences

    Summary
    GPX4/GAPDH: 0.56±0.11 vs. 0.18±0.08
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  24. 24AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR increased renal Nrf2 protein versus LPS alone.

    In plain wordsIn mice, AICAR increased kidney Nrf2 protein compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseNrf2 protein
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    Nrf2/GAPDH
    0.89 ratio
    LPS+AICAR
    Nrf2/GAPDH
    0.36 ratio
    LPS

    Source sentences

    Summary
    Nrf2/GAPDH: 0.89±0.20 vs. 0.36±0.08
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.
  25. 25AnimalAnimal study (in vivo)Mechanism

    In LPS-treated mice, AICAR increased renal HO-1 protein versus LPS alone.

    In plain wordsIn mice, AICAR increased kidney HO-1 protein compared with LPS alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseHO-1 protein
    Study

    mousen = 20

    LPS-induced sepsis-associated acute kidney injury
    Comparator
    LPS group
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    HO-1/GAPDH
    0.75 ratio
    LPS+AICAR
    HO-1/GAPDH
    0.54 ratio
    LPS

    Source sentences

    Summary
    HO-1/GAPDH: 0.75±0.07 vs. 0.54±0.06, all P<0.05].
    2 context sentences
    Summary · context
    Thirty SPF male C57BL/6 mice were randomly assigned to the control group, LPS group, and LPS+AMPK activator (AICAR) group using a random number table method, with 10 mice per group.
    Summary · context
    Mice in the LPS+AICAR group received an intraperitoneal injection of AICAR at a dose of 500 mg/kg for intervention 30 minutes prior to model establishment, while those in the control group and LPS group were intraperitoneally injected with an equal volume of normal saline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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