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Study · Animal study (in vivo) · rabbit · 2026

9 results

TREM-1 inhibition with LR12 attenuates in-stent neoatherosclerosis through modulating macrophage polarization in a rabbit model: An optical coherence tomography study.

Jiang M, Zhang Y, Yuan X, Chen Y, Han Y, Pan X, Zhang X, Ye H, Wang W, Tong W, Gao L

Atherosclerosis5 Mar 2026

PMID41832836 (opens in a new tab)DOI10.1016/j.atherosclerosis.2026.120701 (opens in a new tab)PepBankPUB-41832836
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In stented rabbits, LR12 reduced ISNA area by 40.5% versus saline at 1 month.

    In plain wordsIn rabbits, LR12 reduced artery plaque area within stents compared with saline at 1 month.

    Peptide
    Nangibotide
    Outcome
    DecreaseISNA area at 1 month
    Study

    rabbitn: not reported in source

    High-fat diet and aortic stenting
    Comparator
    Saline
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    ISNA area reduction
    40.5%
    1 month

    Source sentences

    Summary
    OCT demonstrated LR12 markedly attenuated ISNA area (40.5% reduction at 1 month [1.25 ± 0.41 vs. 2.10 ± 0.68 mm2, P = 0.045]; 48.7% at 3 months [2.18 ± 0.49 vs. 4.25 ± 1.33 mm2, P = 0.005])
    1 context sentence
    Summary · context
    A total of 40 rabbits were randomized to receive the TREM-1 inhibitor LR12 or saline post-stenting, with endpoints assessed at 1 and 3 months (n = 10).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In stented rabbits, LR12 reduced ISNA area by 48.7% versus saline at 3 months.

    In plain wordsIn rabbits, LR12 reduced artery plaque area within stents compared with saline at 3 months.

    Peptide
    Nangibotide
    Outcome
    DecreaseISNA area at 3 months
    Study

    rabbitn: not reported in source

    High-fat diet and aortic stenting
    Comparator
    Saline
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    ISNA area reduction
    48.7%
    3 months

    Source sentences

    Summary
    OCT demonstrated LR12 markedly attenuated ISNA area (40.5% reduction at 1 month [1.25 ± 0.41 vs. 2.10 ± 0.68 mm2, P = 0.045]; 48.7% at 3 months [2.18 ± 0.49 vs. 4.25 ± 1.33 mm2, P = 0.005])
    1 context sentence
    Summary · context
    A total of 40 rabbits were randomized to receive the TREM-1 inhibitor LR12 or saline post-stenting, with endpoints assessed at 1 and 3 months (n = 10).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In stented rabbits, LR12 reduced neointimal thickness versus saline at 3 months.

    In plain wordsIn rabbits, LR12 reduced tissue thickness inside stents compared with saline at 3 months.

    Peptide
    Nangibotide
    Outcome
    DecreaseNeointimal thickness
    Study

    rabbitn: not reported in source

    High-fat diet and aortic stenting
    Comparator
    Saline
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and neointimal thickness at 3 months (383.02 ± 59.54 vs. 555.63 ± 136.26 μm, P = 0.004) without impairing stent endothelialization.
    1 context sentence
    Summary · context
    A total of 40 rabbits were randomized to receive the TREM-1 inhibitor LR12 or saline post-stenting, with endpoints assessed at 1 and 3 months (n = 10).
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In stented rabbits, LR12 did not impair stent endothelialization versus saline.

    In plain wordsIn rabbits, LR12 did not impair vessel lining growth over stents compared with saline.

    Peptide
    Nangibotide
    Outcome
    No significant changeStent endothelialization
    Study

    rabbitn: not reported in source

    High-fat diet and aortic stenting
    Comparator
    Saline
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    without impairing stent endothelialization.
    1 context sentence
    Summary · context
    A total of 40 rabbits were randomized to receive the TREM-1 inhibitor LR12 or saline post-stenting, with endpoints assessed at 1 and 3 months (n = 10).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In stented rabbits, LR12 decreased the TNF-α/ARG-1 ratio and shifted macrophages toward the M2 phenotype versus saline.

    In plain wordsIn rabbits, LR12 shifted immune cells toward an anti-inflammatory type compared with saline.

    Peptide
    Nangibotide
    Outcome
    DecreaseMacrophage polarization and TNF-α/ARG-1 ratio
    Study

    rabbitn: not reported in source

    High-fat diet and aortic stenting
    Comparator
    Saline
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    LR12 promoted a shift in macrophage polarization towards anti-inflammatory M2 type (decreased TNF-α/ARG-1 ratio, P < 0.05) and suppressed systematical and local pro-inflammatory cytokines (IL-6, IL-12; P < 0.05).
    1 context sentence
    Summary · context
    A total of 40 rabbits were randomized to receive the TREM-1 inhibitor LR12 or saline post-stenting, with endpoints assessed at 1 and 3 months (n = 10).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In stented rabbits, LR12 suppressed systemic and local IL-6 versus saline.

    In plain wordsIn rabbits, LR12 reduced systemic and local IL-6 compared with saline.

    Peptide
    Nangibotide
    Outcome
    DecreaseSystemic and local IL-6
    Study

    rabbitn: not reported in source

    High-fat diet and aortic stenting
    Comparator
    Saline
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    LR12 promoted a shift in macrophage polarization towards anti-inflammatory M2 type (decreased TNF-α/ARG-1 ratio, P < 0.05) and suppressed systematical and local pro-inflammatory cytokines (IL-6, IL-12; P < 0.05).
    1 context sentence
    Summary · context
    A total of 40 rabbits were randomized to receive the TREM-1 inhibitor LR12 or saline post-stenting, with endpoints assessed at 1 and 3 months (n = 10).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In stented rabbits, LR12 suppressed systemic and local IL-12 versus saline.

    In plain wordsIn rabbits, LR12 reduced systemic and local IL-12 compared with saline.

    Peptide
    Nangibotide
    Outcome
    DecreaseSystemic and local IL-12
    Study

    rabbitn: not reported in source

    High-fat diet and aortic stenting
    Comparator
    Saline
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    LR12 promoted a shift in macrophage polarization towards anti-inflammatory M2 type (decreased TNF-α/ARG-1 ratio, P < 0.05) and suppressed systematical and local pro-inflammatory cytokines (IL-6, IL-12; P < 0.05).
    1 context sentence
    Summary · context
    A total of 40 rabbits were randomized to receive the TREM-1 inhibitor LR12 or saline post-stenting, with endpoints assessed at 1 and 3 months (n = 10).
  8. 08LabIn vitro (cells)Mechanism

    In macrophages in vitro, TREM-1 inhibition with LR12 reduced ox-LDL-induced foam cell formation.

    In plain wordsIn cells, LR12 reduced foam cell formation induced by oxidized LDL.

    Peptide
    Nangibotide
    Outcome
    DecreaseFoam cell formation
    Study

    n: not reported in source

    Macrophages exposed to ox-LDL
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, TREM-1 inhibition reduced ox-LDL-induced foam cell formation and modulated macrophage polarization via the JAK1-STAT1/STAT3 pathway in vitro.
    1 context sentence
    Summary · context
    A total of 40 rabbits were randomized to receive the TREM-1 inhibitor LR12 or saline post-stenting, with endpoints assessed at 1 and 3 months (n = 10).
  9. 09LabIn vitro (cells)Mechanism

    In macrophages in vitro, TREM-1 inhibition with LR12 modulated polarization through the JAK1-STAT1/STAT3 pathway.

    In plain wordsIn cells, LR12 changed immune cell polarization through the JAK1-STAT1/STAT3 pathway.

    Peptide
    Nangibotide
    Outcome
    Not applicableJAK1-STAT1/STAT3-mediated macrophage polarization
    Study

    n: not reported in source

    Macrophages
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, TREM-1 inhibition reduced ox-LDL-induced foam cell formation and modulated macrophage polarization via the JAK1-STAT1/STAT3 pathway in vitro.
    1 context sentence
    Summary · context
    A total of 40 rabbits were randomized to receive the TREM-1 inhibitor LR12 or saline post-stenting, with endpoints assessed at 1 and 3 months (n = 10).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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