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Study · Randomized controlled trial · n = 19 · 2026

3 results

Identification of intranasal oxytocin plasma proteome signatures.

Breithaupt L, Harshman SG, Botros PM, Zhang Z, Holman K, Boutin R, Galbiati F, Maso AA, Lo J, Soukas A, Sadreyev RI, McCormack SE, Lawson EA

Endocrine10 Mar 2026

PMID41806102 (opens in a new tab)DOI10.1007/s12020-025-04529-9 (opens in a new tab)PepBankPUB-41806102
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In fasting men across the adiposity spectrum, intranasal oxytocin changed the levels of 198 serum proteins.

    In plain wordsIn fasting men, intranasal oxytocin changed the levels of 198 blood proteins.

    Peptide
    Oxytocin
    Outcome
    MixedDifferentially expressed serum proteins after oxytocin
    Study

    n = 19

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Measurements

    Differentially expressed proteins
    198 proteins
    intranasal oxytocin

    Source sentences

    Summary
    We identified 198 differentially expressed proteins in response to intranasal oxytocin in fasting men across the adiposity spectrum.
    2 context sentences
    Summary · context
    In a double-blind, randomized controlled crossover design, 25 men were exposed to a single dose of 24 IU intranasal oxytocin vs. placebo.
    Summary · context
    Proteomic data was available for 19 men.
  2. 02HumanRandomized controlled trialMechanism

    In fasting men, the proteins that responded to intranasal oxytocin belonged to intracellular signaling, immune regulation and inflammation pathways.

    In plain wordsIn fasting men, the blood proteins that changed after oxytocin are linked to cell signaling, immune control and inflammation.

    Peptide
    Oxytocin
    Outcome
    Not applicablePathways of oxytocin-responsive proteins
    Study

    n = 19

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    The pathways identified are involved in intracellular signaling pathways, as well as immune regulation and inflammation.
    2 context sentences
    Summary · context
    In a double-blind, randomized controlled crossover design, 25 men were exposed to a single dose of 24 IU intranasal oxytocin vs. placebo.
    Summary · context
    Proteomic data was available for 19 men.
  3. 03HumanRandomized controlled trialMechanism

    In fasting men, intranasal oxytocin modulated a cluster of proteins that was associated with later caloric intake at the test meal.

    In plain wordsIn fasting men, oxytocin changed a group of blood proteins that was linked to how much men ate later.

    Peptide
    Oxytocin
    Outcome
    Not applicableProtein cluster associated with subsequent caloric intake
    Study

    n = 19

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Oxytocin modulated a cluster of proteins that was associated with subsequent caloric intake at the test meal.
    2 context sentences
    Summary · context
    In a double-blind, randomized controlled crossover design, 25 men were exposed to a single dose of 24 IU intranasal oxytocin vs. placebo.
    Summary · context
    Proteomic data was available for 19 men.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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