Skip to content

Study · Animal study (in vivo) · rat · 2026

5 results

Dermorphin blocks apneic response to intravenous bolus injection of fentanyl.

Zhuang J, Gao X, Shi S, Xu F

Toxicology and applied pharmacology7 Mar 2026

PMID41802575 (opens in a new tab)PMCIDPMC13012403 (opens in a new tab)DOI10.1016/j.taap.2026.117785 (opens in a new tab)PepBankPUB-41802575
Read at sourcePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In anesthetized rats, intravenous dermorphin triggered immediate apnea dependent on mu1-opioid receptor activation.

    In plain wordsIn rats, intravenous dermorphin caused immediate apnea through mu1-opioid receptor activation.

    Peptide
    Dermorphin
    Outcome
    IncreaseImmediate apnea
    Study

    ratn: not reported in source

    Anesthetized spontaneously breathing rats
    Outcome group
    Adverse events · Respiratory
    Studied dose
    Dose not stated · intravenous bolusAs given in this study (rat).

    Source sentences

    Summary
    IVb injection of dermorphin triggered an immediate apnea followed by a brief bradypnea, depending on activating μ1-ORs.
    1 context sentence
    Summary · context
    We made three comparisons in anesthetized and spontaneously breathing rats:
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In anesthetized rats, intravenous dermorphin caused brief bradypnea after immediate apnea.

    In plain wordsIn rats, intravenous dermorphin caused a brief period of slow breathing after apnea.

    Peptide
    Dermorphin
    Outcome
    IncreaseBrief bradypnea
    Study

    ratn: not reported in source

    Anesthetized spontaneously breathing rats
    Outcome group
    Adverse events · Respiratory
    Studied dose
    Dose not stated · intravenous bolusAs given in this study (rat).

    Source sentences

    Summary
    IVb injection of dermorphin triggered an immediate apnea followed by a brief bradypnea, depending on activating μ1-ORs.
    1 context sentence
    Summary · context
    We made three comparisons in anesthetized and spontaneously breathing rats:
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In anesthetized rats, respiratory recovery was faster with dermorphin than fentanyl, at 0.5 versus 30 min.

    In plain wordsIn rats, breathing recovered faster after dermorphin than fentanyl, at 0.5 versus 30 min.

    Peptide
    Dermorphin
    Outcome
    DecreaseRecovery of respiratory response
    Study

    ratn: not reported in source

    Anesthetized spontaneously breathing rats
    Comparator
    Fentanyl
    Outcome group
    Adverse events · Respiratory
    Studied dose
    Dose not stated · intravenous bolusAs given in this study (rat).

    Measurements

    Respiratory recovery
    0.5 min
    dermorphin
    Respiratory recovery
    30 min
    fentanyl

    Source sentences

    Summary
    Although dermorphin and fentanyl both elicited a similar immediate apnea, the recovery of respiratory response was much faster in the former than the latter (0.5 min vs. 30 min).
    1 context sentence
    Summary · context
    We made three comparisons in anesthetized and spontaneously breathing rats:
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In anesthetized rats, apnea followed only the first dermorphin injection but each of three fentanyl injections.

    In plain wordsIn rats, apnea followed only the first dermorphin injection but each of three fentanyl injections.

    Peptide
    Dermorphin
    Outcome
    MixedApnea with repeated injections
    Study

    ratn: not reported in source

    Anesthetized spontaneously breathing rats
    Comparator
    Fentanyl injections
    Outcome group
    Adverse events · Respiratory
    Studied dose
    Dose not stated · intravenous bolusAs given in this study (rat).

    Source sentences

    Summary
    Importantly, the apneic response was triggered only by the first dermorphin injection, but always evoked by the three trials of fentanyl injections.
    1 context sentence
    Summary · context
    We made three comparisons in anesthetized and spontaneously breathing rats:
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized rats, dermorphin pretreatment blocked fentanyl-induced apnea.

    In plain wordsIn rats, dermorphin pretreatment blocked apnea caused by fentanyl.

    Peptide
    Dermorphin
    Outcome
    DecreaseFentanyl-induced apnea
    Study

    ratn: not reported in source

    Anesthetized spontaneously breathing rats
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    Dose not stated · intravenous bolusAs given in this study (rat).

    Source sentences

    Summary
    Dermorphin pretreatment blocked fentanyl-induced apnea,
    1 context sentence
    Summary · context
    We made three comparisons in anesthetized and spontaneously breathing rats:

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.