Effect of linaclotide combined with polyethylene glycol on bowel preparation before colonoscopy in patients with constipation.

Liu L, Zeng J, Wang J, Zheng Y, Liu H, Liu Z, Wang R, Gu S

Frontiers in medicine23 Jan 2026Cited by 2 (Europe PMC)

PMID41658593PMCIDPMC12875982DOI10.3389/fmed.2026.1686654PepBankPUB-41658593

Summary

BackgroundLinaclotide, a promising medication for treating irritable bowel syndrome with predominant constipation, has the potential to enhance bowel preparation for colonoscopy. This study aims to evaluate the efficacy and tolerability of linaclotide combined with low-volume polyethylene glycol (PEG) in constipated patients.MethodsIn this randomized, single-blind controlled trial, 210 constipated patients were assigned to one of three groups: (1) 3 L PEG (standard regimen), (2) 2-day linaclotide + 2 L PEG (2D + 2 L PEG), or (3) 4-day linaclotide + 2 L PEG (4D + 2 L PEG). Bowel cleansing was assessed using the Boston Bowel Preparation Scale (BBPS). Adverse symptoms, detection rates of intestinal findings, patient satisfaction, and willingness to repeat the procedure were recorded.ResultsNo significant differences in overall BBPS scores or detection rates were observed among the three groups. However, the 4D + 2 L PEG group showed superior left colon cleansing compared to the 2D + 2 L PEG group. Both linaclotide groups experienced fewer adverse symptoms (bloating, nausea, and vomiting) and reported higher satisfaction than the 3 L PEG group.ConclusionA four-day regimen of oral linaclotide combined with 2 L PEG offers effective and well-tolerated bowel preparation with fewer adverse symptoms, making it a favorable option for constipated patients undergoing colonoscopy.Clinical trial registrationhttp://www.chictr.org.cn (registration no. ChiCTR2400083515).

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

1 result from studies that gave the peptide. 1 result from people.

01HumanRandomized controlled trialEfficacy outcome
In constipated patients, four-day linaclotide plus 2 L PEG provided superior left colon cleansing versus two-day linaclotide plus 2 L PEG.
In plain wordsIn constipated patients, four-day linaclotide improved left colon cleansing versus two-day linaclotide with the same PEG regimen.
Peptide
Linaclotide
Outcome
IncreaseLeft colon cleansing
Study
n: not reported in source
Comparator
2-day linaclotide plus 2 L PEG
Outcome group
Bowel Preparation · Gastrointestinal
Studied dose
Dose not stated · oral · 4 daysAs given in this study (human).
Source sentences
Summary
However, the 4D + 2 L PEG group showed superior left colon cleansing compared to the 2D + 2 L PEG group.
1 context sentence(design, population, supporting numbers)
Summary · context
In this randomized, single-blind controlled trial, 210 constipated patients were assigned to one of three groups: (1) 3 L PEG (standard regimen), (2) 2-day linaclotide + 2 L PEG (2D + 2 L PEG), or (3) 4-day linaclotide + 2 L PEG (4D + 2 L PEG).
Show in the study text Report a problemFND-4165859301

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Version history

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Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:34 UTC
First added · source update from Europe PMC

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