In HaCaT keratinocytes, argireline exhibited cytotoxicity at lower concentrations than Reishi extract.
In plain wordsIn cells, argireline showed toxicity at lower concentrations than Reishi extract.
- Outcome
- DecreaseCytotoxic concentration threshold
- Study
humann: not reported in source
HaCaT keratinocytes- Comparator
- Reishi extract
- Outcome group
- Adverse events · Skin and wound
- Studied dose
- Dose not stated
Source sentences
Reishi extract demonstrated 861 μmol TE/g antioxidant activity, 30% tyrosinase inhibition and a broader safety margin compared with argireline peptide and α-arbutin, which exhibited cytotoxicity at lower concentrations.
1 context sentence(design, population, supporting numbers)
Tyrosinase inhibitory activity was measured with human tyrosinase sourced from MNT-1 melanoma cells, while cytotoxicity and safe dose limits were determined in HaCaT human keratinocyte cells via the AlamarBlue® method.