Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients.

Feng M, Wu C, Jiang Y, Zhao C

International journal of biological macromolecules3 Feb 2026Cited by 1 (Europe PMC)

PMID41628877DOI10.1016/j.ijbiomac.2026.150669PepBankPUB-41628877

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In photoaging mice, AH-8 microneedles significantly reduced visible aging signs, including wrinkles, laxity and erythema.
In plain wordsIn mice, AH-8 microneedles reduced visible skin aging signs.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
DecreaseVisible skin aging signs
Study
mousen: not reported in source
UV/D-galactose-induced photoaging
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
In a UV/D-galactose-induced photoaging mouse model, both EAC-DMNs and AH-8-DMNs significantly reduced visible signs of aging, including wrinkles, skin laxity, and erythema.
Report a problemFND-4162887703
02AnimalAnimal study (in vivo)Efficacy outcome
In photoaging mice, AH-8 microneedles improved skin elasticity.
In plain wordsIn mice, AH-8 microneedles improved skin elasticity.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseSkin elasticity
Study
mousen: not reported in source
UV/D-galactose-induced photoaging
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
They also improved skin elasticity and hydration, reversed pathological thickening, and restored oxidative balance by increasing SOD activity and lowering MDA levels.
1 context sentence(design, population, supporting numbers)
Summary · context
In a UV/D-galactose-induced photoaging mouse model, both EAC-DMNs and AH-8-DMNs significantly reduced visible signs of aging, including wrinkles, skin laxity, and erythema.
Report a problemFND-4162887704
03AnimalAnimal study (in vivo)Efficacy outcome
In photoaging mice, AH-8 microneedles improved skin hydration.
In plain wordsIn mice, AH-8 microneedles improved skin hydration.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseSkin hydration
Study
mousen: not reported in source
UV/D-galactose-induced photoaging
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
They also improved skin elasticity and hydration, reversed pathological thickening, and restored oxidative balance by increasing SOD activity and lowering MDA levels.
1 context sentence(design, population, supporting numbers)
Summary · context
In a UV/D-galactose-induced photoaging mouse model, both EAC-DMNs and AH-8-DMNs significantly reduced visible signs of aging, including wrinkles, skin laxity, and erythema.
Report a problemFND-4162887705
04AnimalAnimal study (in vivo)Efficacy outcome
In photoaging mice, AH-8 microneedles reversed pathological skin thickening.
In plain wordsIn mice, AH-8 microneedles reduced abnormal skin thickening.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
DecreasePathological skin thickening
Study
mousen: not reported in source
UV/D-galactose-induced photoaging
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
They also improved skin elasticity and hydration, reversed pathological thickening, and restored oxidative balance by increasing SOD activity and lowering MDA levels.
1 context sentence(design, population, supporting numbers)
Summary · context
In a UV/D-galactose-induced photoaging mouse model, both EAC-DMNs and AH-8-DMNs significantly reduced visible signs of aging, including wrinkles, skin laxity, and erythema.
Report a problemFND-4162887706
05AnimalAnimal study (in vivo)Mechanism
In photoaging mice, AH-8 microneedles increased SOD activity.
In plain wordsIn mice, AH-8 microneedles increased SOD activity.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseSOD activity
Study
mousen: not reported in source
UV/D-galactose-induced photoaging
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
They also improved skin elasticity and hydration, reversed pathological thickening, and restored oxidative balance by increasing SOD activity and lowering MDA levels.
1 context sentence(design, population, supporting numbers)
Summary · context
In a UV/D-galactose-induced photoaging mouse model, both EAC-DMNs and AH-8-DMNs significantly reduced visible signs of aging, including wrinkles, skin laxity, and erythema.
Report a problemFND-4162887707
06AnimalAnimal study (in vivo)Mechanism
In photoaging mice, AH-8 microneedles lowered MDA levels.
In plain wordsIn mice, AH-8 microneedles lowered MDA levels.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
DecreaseMDA levels
Study
mousen: not reported in source
UV/D-galactose-induced photoaging
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
They also improved skin elasticity and hydration, reversed pathological thickening, and restored oxidative balance by increasing SOD activity and lowering MDA levels.
1 context sentence(design, population, supporting numbers)
Summary · context
In a UV/D-galactose-induced photoaging mouse model, both EAC-DMNs and AH-8-DMNs significantly reduced visible signs of aging, including wrinkles, skin laxity, and erythema.
Report a problemFND-4162887708

Studies that did not test the peptide alone2

In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Argireline (acetyl hexapeptide-8).

07LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueActivity measurement
In pig skin, AH-8 microneedles achieved higher cumulative transdermal delivery than aqueous solution, reaching 11.29%.
In plain wordsIn lab tests with pig skin, AH-8 microneedles delivered more peptide than aqueous solution.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseCumulative transdermal delivery
Study
Bama miniature pign: not reported in source
excised skin permeation
Comparator
Aqueous AH-8 solution
Outcome group
Skin and hair · Skin and wound
Measurements
Cumulative delivery
11.29%
AH-8 microneedles
Source sentences
Summary
Despite these differences, both compounds achieved higher cumulative transdermal delivery (EAC: 17.25%; AH-8: 11.29%) than their aqueous solutions.
1 context sentence(design, population, supporting numbers)
Summary · context
In vitro permeation studies using Bama miniature pig skin revealed release profiles influenced by drug-polymer interactions.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4162887702
08LabNot a test of Argireline (acetyl hexapeptide-8) aloneIn vitro (cell-free)Other
In microneedle fabrication, a split-needle design increased AH-8 loading to 20%.
In plain wordsIn lab tests, a split-needle design increased AH-8 loading to 20%.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseAH-8 loading
Study
n: not reported in source
HA/PVA dissolving microneedles
Outcome group
Skin and hair · Skin and wound
Measurements
AH-8 loading
20%
split-needle design
Source sentences
Summary
A split-needle design further increased drug loading, reaching 40% for EAC and 20% for AH-8.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4162887701

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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