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Study · Randomized controlled trial · n = 35 · 2026

4 results

Impact of chronic oxytocin on gaze and pupil dynamics during live dyadic interactions in children with autism.

Prinsen J, Daniels N, Moerkerke M, Boets B, Alaerts K

Psychoneuroendocrinology10 Jan 2026

PMID41547341 (opens in a new tab)DOI10.1016/j.psyneuen.2026.107745 (opens in a new tab)PepBankPUB-41547341
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In children with autism, four weeks of intranasal oxytocin did not change the overall duration of fixations toward the face of a live interaction partner.

    In plain wordsIn children with autism, oxytocin did not change how long they looked at the face of a live partner, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeDuration of fixations toward the face
    Study

    n = 35

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasal · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    While the overall duration of fixations toward the face remained unchanged
    1 context sentence
    Summary · context
    This double-blind, randomized, placebo-controlled trial examined the effects of four weeks of chronic intranasal oxytocin administration on gaze behavior and pupil dynamics during live dyadic interactions in school-aged children with autism (aged 8-12 years, 15 oxytocin, 20 placebo).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In children with autism, four weeks of intranasal oxytocin produced a more balanced pattern of looking toward and away from the face of a live partner, seen only in the oxytocin group.

    In plain wordsIn children with autism, oxytocin led to a more balanced pattern of looking at and away from a partner's face, not seen with placebo.

    Peptide
    Oxytocin
    Outcome
    MixedDistribution of gaze toward and away from the face
    Study

    n = 35

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasal · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    oxytocin altered the distribution of gaze, resulting in a more balanced pattern of looking toward and away from the face of a live interaction partner, an effect observed only in the oxytocin group and not in the placebo group
    1 context sentence
    Summary · context
    This double-blind, randomized, placebo-controlled trial examined the effects of four weeks of chronic intranasal oxytocin administration on gaze behavior and pupil dynamics during live dyadic interactions in school-aged children with autism (aged 8-12 years, 15 oxytocin, 20 placebo).
  3. 03HumanRandomized controlled trialEfficacy outcome

    In children with autism, four weeks of intranasal oxytocin induced a relative increase in pupil dilation during live interactions.

    In plain wordsIn children with autism, four weeks of oxytocin increased pupil dilation during live interactions, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreasePupil dilation
    Study

    n = 35

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasal · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    the four-week oxytocin administration period induced a relative increase in pupil dilation, an index of sympathetic arousal and attentional engagement
    1 context sentence
    Summary · context
    This double-blind, randomized, placebo-controlled trial examined the effects of four weeks of chronic intranasal oxytocin administration on gaze behavior and pupil dynamics during live dyadic interactions in school-aged children with autism (aged 8-12 years, 15 oxytocin, 20 placebo).
  4. 04HumanRandomized controlled trialOther

    In children with autism given oxytocin, the heightened pupil responsivity showed a moderate association with self-reported feelings of secure attachment.

    In plain wordsIn children with autism given oxytocin, the stronger pupil response was linked to their reports of feeling securely attached.

    Peptide
    Oxytocin
    Outcome
    Not applicableAssociation of pupil responsivity with secure attachment
    Study

    n = 35

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasal · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    with this heightened autonomic responsivity showing a moderate association with children's self-reported feelings of secure attachment
    1 context sentence
    Summary · context
    This double-blind, randomized, placebo-controlled trial examined the effects of four weeks of chronic intranasal oxytocin administration on gaze behavior and pupil dynamics during live dyadic interactions in school-aged children with autism (aged 8-12 years, 15 oxytocin, 20 placebo).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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