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Study · Animal study (in vivo) · mouse · 2026

6 results

Growth hormone releasing peptide-6 (GHRP-6) ameliorates acute lung injury and its subsequent evolvement to interstitial fibrosis.

Wang L, Berlanga-Acosta J, Yu H, García-Ojalvo A, Jiang T, Li N, Zhang Z, Guillén-Nieto G, Jiang B

International immunopharmacology13 Jan 2026

PMID41534456 (opens in a new tab)DOI10.1016/j.intimp.2026.116204 (opens in a new tab)PepBankPUB-41534456
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute lung injury, GHRP‑6 reduced neutrophilic alveolitis versus saline.

    In plain wordsIn mice with acute lung injury, GHRP‑6 reduced neutrophilic alveolitis versus saline.

    Peptide
    GHRP-6
    Outcome
    DecreaseNeutrophilic alveolitis
    Study

    mousen: not reported in source

    LPS- or ZYM/PAF-induced lung injury
    Comparator
    Normal saline
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The acute scenario, GHRP-6 reduced neutrophilic alveolitis, attenuated lung compliance failure, contributed to improve alveolar-capillary permeability, and reduced interleukin-1 beta serum levels.
    1 context sentence
    Summary · context
    We examined the ability of growth hormone releasing peptide 6 (GHRP-6) to attenuate the pulmonary damages associated with intratracheal instillation of LPS or ZYM combined injection with platelet activating factor (PAF) in mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute lung injury, GHRP‑6 attenuated lung compliance failure versus saline.

    In plain wordsIn mice with acute lung injury, GHRP‑6 reduced lung compliance failure versus saline.

    Peptide
    GHRP-6
    Outcome
    DecreaseLung compliance failure
    Study

    mousen: not reported in source

    LPS- or ZYM/PAF-induced lung injury
    Comparator
    Normal saline
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The acute scenario, GHRP-6 reduced neutrophilic alveolitis, attenuated lung compliance failure, contributed to improve alveolar-capillary permeability, and reduced interleukin-1 beta serum levels.
    1 context sentence
    Summary · context
    We examined the ability of growth hormone releasing peptide 6 (GHRP-6) to attenuate the pulmonary damages associated with intratracheal instillation of LPS or ZYM combined injection with platelet activating factor (PAF) in mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute lung injury, GHRP‑6 improved alveolar-capillary permeability versus saline.

    In plain wordsIn mice with acute lung injury, GHRP‑6 improved alveolar-capillary permeability versus saline.

    Peptide
    GHRP-6
    Outcome
    Direction not reportedAlveolar-capillary permeability
    Study

    mousen: not reported in source

    LPS- or ZYM/PAF-induced lung injury
    Comparator
    Normal saline
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The acute scenario, GHRP-6 reduced neutrophilic alveolitis, attenuated lung compliance failure, contributed to improve alveolar-capillary permeability, and reduced interleukin-1 beta serum levels.
    1 context sentence
    Summary · context
    We examined the ability of growth hormone releasing peptide 6 (GHRP-6) to attenuate the pulmonary damages associated with intratracheal instillation of LPS or ZYM combined injection with platelet activating factor (PAF) in mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute lung injury, GHRP‑6 reduced serum interleukin-1 beta versus saline.

    In plain wordsIn mice with acute lung injury, GHRP‑6 reduced serum interleukin-1 beta versus saline.

    Peptide
    GHRP-6
    Outcome
    DecreaseSerum interleukin-1 beta
    Study

    mousen: not reported in source

    LPS- or ZYM/PAF-induced lung injury
    Comparator
    Normal saline
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The acute scenario, GHRP-6 reduced neutrophilic alveolitis, attenuated lung compliance failure, contributed to improve alveolar-capillary permeability, and reduced interleukin-1 beta serum levels.
    1 context sentence
    Summary · context
    We examined the ability of growth hormone releasing peptide 6 (GHRP-6) to attenuate the pulmonary damages associated with intratracheal instillation of LPS or ZYM combined injection with platelet activating factor (PAF) in mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with chronic lung injury, GHRP‑6 preserved lung parenchymal integrity versus saline.

    In plain wordsIn mice with chronic lung injury, GHRP‑6 preserved lung tissue integrity versus saline.

    Peptide
    GHRP-6
    Outcome
    Direction not reportedLung parenchymal integrity
    Study

    mousen: not reported in source

    LPS- or ZYM/PAF-induced lung injury
    Comparator
    Normal saline
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The chronic scenario, GHRP-6 preserved lung parenchymal integrity accounted for meager collagen accumulation.
    1 context sentence
    Summary · context
    We examined the ability of growth hormone releasing peptide 6 (GHRP-6) to attenuate the pulmonary damages associated with intratracheal instillation of LPS or ZYM combined injection with platelet activating factor (PAF) in mice.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with chronic lung injury, GHRP‑6 treatment resulted in meager collagen accumulation versus saline.

    In plain wordsIn mice with chronic lung injury, GHRP‑6 limited collagen accumulation versus saline.

    Peptide
    GHRP-6
    Outcome
    DecreaseCollagen accumulation
    Study

    mousen: not reported in source

    LPS- or ZYM/PAF-induced lung injury
    Comparator
    Normal saline
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The chronic scenario, GHRP-6 preserved lung parenchymal integrity accounted for meager collagen accumulation.
    1 context sentence
    Summary · context
    We examined the ability of growth hormone releasing peptide 6 (GHRP-6) to attenuate the pulmonary damages associated with intratracheal instillation of LPS or ZYM combined injection with platelet activating factor (PAF) in mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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