Effect of Systemic Oxytocin Administration on the Healing of Mandibular Fractures.

Kale Ş, Çakır Gündoğdu A, Ayyıldız H, Altay B

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons5 Dec 2025

PMID41429185DOI10.1016/j.joms.2025.11.017PepBankPUB-41429185

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with mandibular fractures, oxytocin did not significantly change fracture healing measures on day 10 compared with control.
In plain wordsIn rats with jaw fractures, oxytocin made no significant difference to bone healing after 10 days compared with control.
Peptide
Oxytocin
Outcome
No significant changeRadiographic fracture healing at day 10
Study
Wistar ratn: not reported in source
Mandibular fracture model
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Although no significant difference was observed on day 10
2 context sentences(design, population, supporting numbers)
Summary · context
This is an in vivo animal study using a mandibular fracture model in 42, 6-month-old male Wistar rats.
Summary · context
The animals were randomly assigned to OT or control groups (C).
Report a problemFND-4142918501
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with mandibular fractures, oxytocin gave a significantly higher gray value than control on day 20.
In plain wordsIn rats with jaw fractures, oxytocin gave higher bone gray values than control after 20 days.
Peptide
Oxytocin
Outcome
IncreaseGray value (GV) at day 20
Study
Wistar ratn: not reported in source
Mandibular fracture model
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Measurements
GV
1.35 GV
OT-20
GV
0.77 GV
C-20
Source sentences
Summary
on day 20, OT-20 subgroup demonstrated significantly higher GV (OT-20 = 1.35 ± 0.39, C-20 = 0.77 ± 0.24) (P = .011 < 0.05)
2 context sentences(design, population, supporting numbers)
Summary · context
This is an in vivo animal study using a mandibular fracture model in 42, 6-month-old male Wistar rats.
Summary · context
The animals were randomly assigned to OT or control groups (C).
Report a problemFND-4142918502
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with mandibular fractures, oxytocin gave a significantly higher fracture healing score than control on day 20.
In plain wordsIn rats with jaw fractures, oxytocin gave higher fracture healing scores than control after 20 days.
Peptide
Oxytocin
Outcome
IncreaseFracture healing score (FHS) at day 20
Study
Wistar ratn: not reported in source
Mandibular fracture model
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Measurements
FHS
7.83 score
OT-20
FHS
5.67 score
C-20
Source sentences
Summary
FHS values (OT-20 = 7.83 ± 0.75, C-20 = 5.67 ± 1.21) (P = .004 < 0.05)
2 context sentences(design, population, supporting numbers)
Summary · context
This is an in vivo animal study using a mandibular fracture model in 42, 6-month-old male Wistar rats.
Summary · context
The animals were randomly assigned to OT or control groups (C).
Report a problemFND-4142918503
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with mandibular fractures, oxytocin gave a significantly higher ratio of new bone area to total fracture area than control on day 20.
In plain wordsIn rats with jaw fractures, oxytocin produced a larger share of new bone than control after 20 days.
Peptide
Oxytocin
Outcome
IncreaseNew bone to total fracture area ratio (NB/TF) at day 20
Study
Wistar ratn: not reported in source
Mandibular fracture model
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Measurements
NB/TF
80.19 ratio
OT-20
NB/TF
31.4 ratio
C-20
Source sentences
Summary
NB/TF ratios (OT-20 = 80.19 ± 4.93, C-20 = 31.40 ± 3.87) (P = .001 < 0.05)
2 context sentences(design, population, supporting numbers)
Summary · context
This is an in vivo animal study using a mandibular fracture model in 42, 6-month-old male Wistar rats.
Summary · context
The animals were randomly assigned to OT or control groups (C).
Report a problemFND-4142918504
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with mandibular fractures, oxytocin kept a significantly higher gray value than control on day 30.
In plain wordsIn rats with jaw fractures, oxytocin still gave higher bone gray values than control after 30 days.
Peptide
Oxytocin
Outcome
IncreaseGray value (GV) at day 30
Study
Wistar ratn: not reported in source
Mandibular fracture model
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
On day 30, OT-30 maintained this superiority, showing significantly higher GV, FHS, and NB/TF values compared to C-30 (all P < .05).
2 context sentences(design, population, supporting numbers)
Summary · context
This is an in vivo animal study using a mandibular fracture model in 42, 6-month-old male Wistar rats.
Summary · context
The animals were randomly assigned to OT or control groups (C).
Report a problemFND-4142918505
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with mandibular fractures, oxytocin kept a significantly higher fracture healing score than control on day 30.
In plain wordsIn rats with jaw fractures, oxytocin still gave higher fracture healing scores than control after 30 days.
Peptide
Oxytocin
Outcome
IncreaseFracture healing score (FHS) at day 30
Study
Wistar ratn: not reported in source
Mandibular fracture model
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
On day 30, OT-30 maintained this superiority, showing significantly higher GV, FHS, and NB/TF values compared to C-30 (all P < .05).
2 context sentences(design, population, supporting numbers)
Summary · context
This is an in vivo animal study using a mandibular fracture model in 42, 6-month-old male Wistar rats.
Summary · context
The animals were randomly assigned to OT or control groups (C).
Report a problemFND-4142918506
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with mandibular fractures, oxytocin kept a significantly higher new bone to total fracture area ratio than control on day 30.
In plain wordsIn rats with jaw fractures, oxytocin still gave a larger share of new bone than control after 30 days.
Peptide
Oxytocin
Outcome
IncreaseNew bone to total fracture area ratio (NB/TF) at day 30
Study
Wistar ratn: not reported in source
Mandibular fracture model
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
On day 30, OT-30 maintained this superiority, showing significantly higher GV, FHS, and NB/TF values compared to C-30 (all P < .05).
2 context sentences(design, population, supporting numbers)
Summary · context
This is an in vivo animal study using a mandibular fracture model in 42, 6-month-old male Wistar rats.
Summary · context
The animals were randomly assigned to OT or control groups (C).
Report a problemFND-4142918507

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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