Skip to content

Study · Not a test of the peptide alone · 2025

1 result

Structural basis for pharmacotherapeutic action of triple reuptake inhibitors.

Li Y, Meng Y, Li N, Zhao J, Li R, Bai Q, Wang G, Zhao Y

Nature communications14 Dec 2025Cited by 3 (Europe PMC)

PMID41392177 (opens in a new tab)PMCIDPMC12769732 (opens in a new tab)DOI10.1038/s41467-025-66670-3 (opens in a new tab)PepBankPUB-41392177
Read at sourcePubMedAsk about this study
Jump to 1 result

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Tesofensine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Tesofensine.

  1. 01LabNot a test of Tesofensine aloneIn vitro (cell-free)Mechanism

    In structural studies, tesofensine stabilized DAT in an outward-facing conformation.

    In plain wordsIn lab tests, tesofensine held the dopamine transporter in an outward-facing shape.

    Peptide
    Tesofensine
    Outcome
    Not applicableDAT conformation
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Tesofensine and dasotraline stabilize DAT in an outward-facing conformation,
    1 context sentence
    Summary · context
    Here, we determine an ensemble of structures of DAT in complex with five distinct TRIs.

    In this study, Tesofensine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tesofensine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.