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Study · Not a test of the peptide alone · 2026

6 results

Golgi-targeted copper delivery strategy via enhancing copper-dependent proteins' activity for fascia regeneration.

Wang R, Xu Y, Saiding Q, Ling S, Yu J, Zhuang Y, Cui W, Chen X

Journal of controlled release : official journal of the Controlled Release Society8 Dec 2025

PMID41371501 (opens in a new tab)DOI10.1016/j.jconrel.2025.114521 (opens in a new tab)PepBankPUB-41371501
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK-Cu.

  1. 01AnimalNot a test of GHK-Cu aloneAnimal study (in vivo)Efficacy outcome

    In a rabbit fascia defect model, the Golgi-targeted copper delivery strategy promoted collagen alignment.

    In plain wordsIn rabbits with a fascia defect, a copper delivery system improved how collagen lined up.

    Peptide
    GHK-Cu
    Outcome
    IncreaseCollagen alignment
    Study

    rabbitn: not reported in source

    Fascia defect model
    Outcome group
    Wound healing · Musculoskeletal

    Source sentences

    Summary
    In a rabbit fascia defect model, this strategy effectively promoted collagen alignment
    1 context sentence
    Summary · context
    To address this issue, this study, for the first time, proposes and validates a Golgi-targeted copper delivery system (LNP-ATOX1/GHK-Cu@PCL-GelMA).

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  2. 02AnimalNot a test of GHK-Cu aloneAnimal study (in vivo)Efficacy outcome

    In a rabbit fascia defect model, the Golgi-targeted copper delivery strategy promoted neovascularization.

    In plain wordsIn rabbits with a fascia defect, a copper delivery system promoted growth of new blood vessels.

    Peptide
    GHK-Cu
    Outcome
    IncreaseNeovascularization
    Study

    rabbitn: not reported in source

    Fascia defect model
    Outcome group
    Wound healing · Cardiovascular

    Source sentences

    Summary
    In a rabbit fascia defect model, this strategy effectively promoted collagen alignment and neovascularization
    1 context sentence
    Summary · context
    To address this issue, this study, for the first time, proposes and validates a Golgi-targeted copper delivery system (LNP-ATOX1/GHK-Cu@PCL-GelMA).

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  3. 03AnimalNot a test of GHK-Cu aloneAnimal study (in vivo)Efficacy outcome

    In a rabbit fascia defect model, the Golgi-targeted copper delivery strategy improved extracellular matrix reconstruction and facilitated fascia regeneration.

    In plain wordsIn rabbits with a fascia defect, a copper delivery system helped rebuild tissue and regrow fascia.

    Peptide
    GHK-Cu
    Outcome
    IncreaseFascia regeneration and extracellular matrix reconstruction
    Study

    rabbitn: not reported in source

    Fascia defect model
    Outcome group
    Wound healing · Musculoskeletal

    Source sentences

    Summary
    improving extracellular matrix reconstruction and facilitating fascia regeneration.
    2 context sentences
    Summary · context
    In a rabbit fascia defect model
    Summary · context
    To address this issue, this study, for the first time, proposes and validates a Golgi-targeted copper delivery system (LNP-ATOX1/GHK-Cu@PCL-GelMA).

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  4. 04LabNot a test of GHK-Cu aloneIn vitro (cells)Mechanism

    In vitro, the Golgi-targeted copper delivery system significantly increased copper accumulation within the Golgi apparatus.

    In plain wordsIn lab tests, a copper delivery system raised the copper level inside the Golgi part of cells.

    Peptide
    GHK-Cu
    Outcome
    IncreaseGolgi copper accumulation
    Study

    n: not reported in source

    Comparator
    Control group
    Outcome group
    Receptor activity and mechanism · Whole body

    Source sentences

    Summary
    In vitro studies demonstrated that this material system significantly increased copper accumulation within the Golgi apparatus
    1 context sentence
    Summary · context
    To address this issue, this study, for the first time, proposes and validates a Golgi-targeted copper delivery system (LNP-ATOX1/GHK-Cu@PCL-GelMA).

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  5. 05LabNot a test of GHK-Cu aloneIn vitro (cells)Mechanism

    In vitro, the Golgi-targeted copper delivery system elevated LOX activity to 1.78 times that of the control group.

    In plain wordsIn lab tests, a copper delivery system raised the activity of the enzyme LOX to 1.78 times the control.

    Peptide
    GHK-Cu
    Outcome
    IncreaseLOX activity
    Study

    n: not reported in source

    Comparator
    Control group
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Measurements

    LOX activity relative to control
    1.78 times
    in vitro

    Source sentences

    Summary
    In vitro studies demonstrated that this material system significantly increased copper accumulation within the Golgi apparatus, elevated LOX activity to 1.78 times that of the control group
    1 context sentence
    Summary · context
    To address this issue, this study, for the first time, proposes and validates a Golgi-targeted copper delivery system (LNP-ATOX1/GHK-Cu@PCL-GelMA).

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  6. 06LabNot a test of GHK-Cu aloneIn vitro (cells)Efficacy outcome

    In vitro, the Golgi-targeted copper delivery system enhanced angiogenic capacity.

    In plain wordsIn lab tests, a copper delivery system increased the ability of cells to form new blood vessels.

    Peptide
    GHK-Cu
    Outcome
    IncreaseAngiogenic capacity
    Study

    n: not reported in source

    Outcome group
    Wound healing · Cardiovascular

    Source sentences

    Summary
    In vitro studies demonstrated that this material system significantly increased copper accumulation within the Golgi apparatus, elevated LOX activity to 1.78 times that of the control group, and enhanced angiogenic capacity
    1 context sentence
    Summary · context
    To address this issue, this study, for the first time, proposes and validates a Golgi-targeted copper delivery system (LNP-ATOX1/GHK-Cu@PCL-GelMA).

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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