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Study · Randomized controlled trial · 2026

5 results

Age-dependent effects of intranasal oxytocin administration were revealed by resting brain entropy (BEN).

Song D, Wang Z

Behavioural brain research6 Dec 2025Cited by 2 (Europe PMC)

PMID41360155 (opens in a new tab)DOI10.1016/j.bbr.2025.115985 (opens in a new tab)PepBankPUB-41360155
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In young adults, intranasal oxytocin increased resting brain entropy in the left temporoparietal junction compared with placebo.

    In plain wordsIn young adults, oxytocin spray increased a measure of brain signal irregularity in one brain area compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseBrain entropy in left TPJ, young adults
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    we identified a significant age-dependent effect in the left temporoparietal junction (TPJ), where OT increased BEN in YA but decreased it in OA.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, young adults (YA) and older adults (OA) were assigned to receive intranasal OT or placebo (PL).
  2. 02HumanRandomized controlled trialMechanism

    In older adults, intranasal oxytocin decreased resting brain entropy in the left temporoparietal junction compared with placebo.

    In plain wordsIn older adults, oxytocin spray decreased a measure of brain signal irregularity in one brain area compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseBrain entropy in left TPJ, older adults
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    we identified a significant age-dependent effect in the left temporoparietal junction (TPJ), where OT increased BEN in YA but decreased it in OA.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, young adults (YA) and older adults (OA) were assigned to receive intranasal OT or placebo (PL).
  3. 03HumanRandomized controlled trialMechanism

    Intranasal oxytocin elevated the fractional amplitude of low-frequency fluctuations in the left temporoparietal junction, particularly in young adults.

    In plain wordsOxytocin spray raised slow brain signal strength in one brain area, mostly in young adults.

    Peptide
    Oxytocin
    Outcome
    IncreasefALFF in left TPJ
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Further analyses showed OT also elevated the fractional amplitude of low-frequency fluctuations (fALFF) in the same region, particularly in YA.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, young adults (YA) and older adults (OA) were assigned to receive intranasal OT or placebo (PL).
  4. 04HumanRandomized controlled trialMechanism

    Intranasal oxytocin enhanced functional connectivity within the left temporoparietal junction in both age groups.

    In plain wordsOxytocin spray strengthened brain signal connections within one brain area in both young and older adults.

    Peptide
    Oxytocin
    Outcome
    IncreaseFunctional connectivity within the left TPJ
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Additionally, OT enhanced functional connectivity within the left TPJ and between the left and right TPJ in both age groups.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, young adults (YA) and older adults (OA) were assigned to receive intranasal OT or placebo (PL).
  5. 05HumanRandomized controlled trialMechanism

    Intranasal oxytocin enhanced functional connectivity between the left and right temporoparietal junction in both age groups.

    In plain wordsOxytocin spray strengthened brain signal connections between the left and right brain areas in both young and older adults.

    Peptide
    Oxytocin
    Outcome
    IncreaseFunctional connectivity between left and right TPJ
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Additionally, OT enhanced functional connectivity within the left TPJ and between the left and right TPJ in both age groups.
    1 context sentence
    Summary · context
    In a randomized, double-blind, placebo-controlled trial, young adults (YA) and older adults (OA) were assigned to receive intranasal OT or placebo (PL).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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