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Study · Animal study (in vivo) · mouse · 2025

5 results

Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation.

Zhao X, Pan K, Li R, Liu M, Li D, Jia P, Han Z, Han ZC, Guo Z, Li Z, Li Q

Journal of nanobiotechnology1 Dec 2025Cited by 1 (Europe PMC)

PMID41327290 (opens in a new tab)PMCIDPMC12777158 (opens in a new tab)DOI10.1186/s12951-025-03888-9 (opens in a new tab)PepBankPUB-41327290
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice with acute kidney injury, spermidine was highly enriched after GHRP‑6 hydrogel treatment.

    In plain wordsIn mice with acute kidney injury, spermidine was highly enriched after GHRP‑6 hydrogel treatment.

    Peptide
    GHRP-6
    Outcome
    IncreaseSpermidine enrichment
    Study

    mousen: not reported in source

    Acute kidney injury treated with GHRP-6 hydrogel
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Metabolomic sequencing analysis revealed that spermidine, L-glutamine, and acetyl-CoA, which are involved in amino acid and fatty acid metabolism, were highly enriched in a mouse model of AKI treated with the GHRP-6 hydrogel.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice with acute kidney injury, L-glutamine was highly enriched after GHRP‑6 hydrogel treatment.

    In plain wordsIn mice with acute kidney injury, L-glutamine was highly enriched after GHRP‑6 hydrogel treatment.

    Peptide
    GHRP-6
    Outcome
    IncreaseL-glutamine enrichment
    Study

    mousen: not reported in source

    Acute kidney injury treated with GHRP-6 hydrogel
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Metabolomic sequencing analysis revealed that spermidine, L-glutamine, and acetyl-CoA, which are involved in amino acid and fatty acid metabolism, were highly enriched in a mouse model of AKI treated with the GHRP-6 hydrogel.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with acute kidney injury, acetyl-CoA was highly enriched after GHRP‑6 hydrogel treatment.

    In plain wordsIn mice with acute kidney injury, acetyl-CoA was highly enriched after GHRP‑6 hydrogel treatment.

    Peptide
    GHRP-6
    Outcome
    IncreaseAcetyl-CoA enrichment
    Study

    mousen: not reported in source

    Acute kidney injury treated with GHRP-6 hydrogel
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Metabolomic sequencing analysis revealed that spermidine, L-glutamine, and acetyl-CoA, which are involved in amino acid and fatty acid metabolism, were highly enriched in a mouse model of AKI treated with the GHRP-6 hydrogel.
  4. 04LabOther designEfficacy outcome

    In renal tubular epithelial cells in an ischemic microenvironment, GHRP‑6 hydrogel enhanced cell survival.

    In plain wordsIn cells in an ischemic microenvironment, GHRP‑6 hydrogel increased renal tubular epithelial cell survival.

    Peptide
    GHRP-6
    Outcome
    IncreaseTubular epithelial cell survival
    Study

    n: not reported in source

    Renal tubular epithelial cells in an ischemic microenvironment
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further study revealed that GHRP-6 hydrogel treatment enhanced the survival of TECs in the ischemic microenvironment by activating the mTOR-P70 pathway.
  5. 05LabOther designMechanism

    In renal tubular epithelial cells in an ischemic microenvironment, GHRP‑6 hydrogel activated the mTOR-P70 pathway.

    In plain wordsIn cells in an ischemic microenvironment, GHRP‑6 hydrogel activated the mTOR-P70 pathway.

    Peptide
    GHRP-6
    Outcome
    IncreasemTOR-P70 pathway activation
    Study

    n: not reported in source

    Renal tubular epithelial cells in an ischemic microenvironment
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further study revealed that GHRP-6 hydrogel treatment enhanced the survival of TECs in the ischemic microenvironment by activating the mTOR-P70 pathway.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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