Mechanical growth factor inhibited syndesmophyte formation and the progression of osteoarthritis and ankylosing spondylitis-like symptoms in HLA-B27/Hu-β2m transgenic rats.

Moro A, Qin H, Yuan S, Li H, Liao S, Yang J

Arthritis research & therapy21 Nov 2025Cited by 1 (Europe PMC)

PMID41272763PMCIDPMC12639975DOI10.1186/s13075-025-03677-7PepBankPUB-41272763

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Summary

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Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In HLA-B27/Hu-β2m transgenic rats, MGF increased the time to onset of arthritis symptoms in a dose-dependent way, from 14 days in controls to 23 days at the high dose.
In plain wordsIn rats with induced arthritis, MGF delayed the start of arthritis symptoms in a dose-dependent way compared with the control group.
Peptide
MGF / PEG-MGF
Outcome
IncreaseTime to onset of arthritis symptoms
Study
ratn: not reported in source
HLA-B27/Hu-β2m transgenic rats with induced arthritis and ankylosing spondylitis
Comparator
Control group
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · seven weeksAs given in this study (rat).
Measurements
Time to onset
14 days
control group
Time to onset
23 days
high-dose MGF
Source sentences
Summary
Our results indicated a dose-dependent increase in the time of onset of arthritis symptoms from 14 days in the control group to 23 days in the high-dose MGF group.
1 context sentence(design, population, supporting numbers)
Summary · context
HLA-B27/ Hu-β2m transgenic rats were inoculated with inactivated Mycobacterium tuberculosis to induce arthritis and ankylosing spondylitis, followed by MGF treatment for seven weeks.
Report a problemFND-4127276301
02AnimalAnimal study (in vivo)Mechanism
In HLA-B27/Hu-β2m transgenic rats, MGF increased the anti-inflammatory cytokine IL-2 in a dose-dependent way.
In plain wordsIn rats with induced arthritis, MGF raised the anti-inflammatory signal IL-2 in a dose-dependent way.
Peptide
MGF / PEG-MGF
Outcome
IncreaseIL-2 level
Study
ratn: not reported in source
HLA-B27/Hu-β2m transgenic rats with induced arthritis and ankylosing spondylitis
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · seven weeksAs given in this study (rat).
Source sentences
Summary
Our results also indicated a dose-dependent increase in the anti-inflammatory cytokines IL-2 and IL-10 and decrease in the pro-inflammatory cytokine TNF-α in the peripheral circulation and in bony infiltrations.
1 context sentence(design, population, supporting numbers)
Summary · context
HLA-B27/ Hu-β2m transgenic rats were inoculated with inactivated Mycobacterium tuberculosis to induce arthritis and ankylosing spondylitis, followed by MGF treatment for seven weeks.
Report a problemFND-4127276302
03AnimalAnimal study (in vivo)Mechanism
In HLA-B27/Hu-β2m transgenic rats, MGF increased the anti-inflammatory cytokine IL-10 in a dose-dependent way.
In plain wordsIn rats with induced arthritis, MGF raised the anti-inflammatory signal IL-10 in a dose-dependent way.
Peptide
MGF / PEG-MGF
Outcome
IncreaseIL-10 level
Study
ratn: not reported in source
HLA-B27/Hu-β2m transgenic rats with induced arthritis and ankylosing spondylitis
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · seven weeksAs given in this study (rat).
Source sentences
Summary
Our results also indicated a dose-dependent increase in the anti-inflammatory cytokines IL-2 and IL-10 and decrease in the pro-inflammatory cytokine TNF-α in the peripheral circulation and in bony infiltrations.
1 context sentence(design, population, supporting numbers)
Summary · context
HLA-B27/ Hu-β2m transgenic rats were inoculated with inactivated Mycobacterium tuberculosis to induce arthritis and ankylosing spondylitis, followed by MGF treatment for seven weeks.
Report a problemFND-4127276303
04AnimalAnimal study (in vivo)Mechanism
In HLA-B27/Hu-β2m transgenic rats, MGF decreased the pro-inflammatory cytokine TNF-α in a dose-dependent way.
In plain wordsIn rats with induced arthritis, MGF lowered the inflammatory signal TNF-α in a dose-dependent way.
Peptide
MGF / PEG-MGF
Outcome
DecreaseTNF-α level
Study
ratn: not reported in source
HLA-B27/Hu-β2m transgenic rats with induced arthritis and ankylosing spondylitis
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · seven weeksAs given in this study (rat).
Source sentences
Summary
Our results also indicated a dose-dependent increase in the anti-inflammatory cytokines IL-2 and IL-10 and decrease in the pro-inflammatory cytokine TNF-α in the peripheral circulation and in bony infiltrations.
1 context sentence(design, population, supporting numbers)
Summary · context
HLA-B27/ Hu-β2m transgenic rats were inoculated with inactivated Mycobacterium tuberculosis to induce arthritis and ankylosing spondylitis, followed by MGF treatment for seven weeks.
Report a problemFND-4127276304
05AnimalAnimal study (in vivo)Mechanism
In HLA-B27/Hu-β2m transgenic rats, MGF inhibited STAT3 expression in a dose-dependent way.
In plain wordsIn rats with induced arthritis, MGF lowered STAT3 expression in a dose-dependent way.
Peptide
MGF / PEG-MGF
Outcome
DecreaseSTAT3 expression
Study
ratn: not reported in source
HLA-B27/Hu-β2m transgenic rats with induced arthritis and ankylosing spondylitis
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · seven weeksAs given in this study (rat).
Source sentences
Summary
Likewise, there was a dose-dependent inhibition of STAT3 (signal transducer and activator of transcription 3) and RORγt (retinoic acid-related orphan receptor gamma-t) expression, which was further confirmed by the inhibition of IL-17 expression.
1 context sentence(design, population, supporting numbers)
Summary · context
HLA-B27/ Hu-β2m transgenic rats were inoculated with inactivated Mycobacterium tuberculosis to induce arthritis and ankylosing spondylitis, followed by MGF treatment for seven weeks.
Report a problemFND-4127276305
06AnimalAnimal study (in vivo)Mechanism
In HLA-B27/Hu-β2m transgenic rats, MGF inhibited RORγt expression in a dose-dependent way.
In plain wordsIn rats with induced arthritis, MGF lowered RORγt expression in a dose-dependent way.
Peptide
MGF / PEG-MGF
Outcome
DecreaseRORγt expression
Study
ratn: not reported in source
HLA-B27/Hu-β2m transgenic rats with induced arthritis and ankylosing spondylitis
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · seven weeksAs given in this study (rat).
Source sentences
Summary
Likewise, there was a dose-dependent inhibition of STAT3 (signal transducer and activator of transcription 3) and RORγt (retinoic acid-related orphan receptor gamma-t) expression, which was further confirmed by the inhibition of IL-17 expression.
1 context sentence(design, population, supporting numbers)
Summary · context
HLA-B27/ Hu-β2m transgenic rats were inoculated with inactivated Mycobacterium tuberculosis to induce arthritis and ankylosing spondylitis, followed by MGF treatment for seven weeks.
Report a problemFND-4127276306
07AnimalAnimal study (in vivo)Mechanism
In HLA-B27/Hu-β2m transgenic rats, MGF inhibited IL-17 expression in a dose-dependent way.
In plain wordsIn rats with induced arthritis, MGF lowered IL-17 expression in a dose-dependent way.
Peptide
MGF / PEG-MGF
Outcome
DecreaseIL-17 expression
Study
ratn: not reported in source
HLA-B27/Hu-β2m transgenic rats with induced arthritis and ankylosing spondylitis
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · seven weeksAs given in this study (rat).
Source sentences
Summary
Likewise, there was a dose-dependent inhibition of STAT3 (signal transducer and activator of transcription 3) and RORγt (retinoic acid-related orphan receptor gamma-t) expression, which was further confirmed by the inhibition of IL-17 expression.
1 context sentence(design, population, supporting numbers)
Summary · context
HLA-B27/ Hu-β2m transgenic rats were inoculated with inactivated Mycobacterium tuberculosis to induce arthritis and ankylosing spondylitis, followed by MGF treatment for seven weeks.
Report a problemFND-4127276307

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

Keywords

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