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Study · Ex vivo tissue · rat · 2025

2 results

The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons.

Kolbaev SN, Sharonova IN, Skrebitsky VG

Bulletin of experimental biology and medicine1 Aug 2025

PMID41171324 (opens in a new tab)DOI10.1007/s10517-025-06501-z (opens in a new tab)PepBankPUB-41171324
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat hippocampal slices, Semax at 1 μM increased the frequency of spontaneous intracellular calcium fluctuations in CA1 pyramidal layer cells.

    In plain wordsIn lab tests on rat brain slices, Semax made calcium levels in hippocampal nerve cells fluctuate more often.

    Peptide
    Semax
    Outcome
    IncreaseSpontaneous intracellular calcium fluctuation frequency, hippocampal CA1 pyramidal neurons
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 μMAs given in this study (rat).

    Source sentences

    Summary
    Application of Semax (1 μM), significantly increased the frequency of spontaneous [Ca2+]i fluctuations in the pyramidal layer cells of the hippocampal CA1 field
    1 context sentence
    Summary · context
    We studied the effects of Semax on spontaneous fluctuations of intracellular calcium ion concentration [Ca2+]i in pyramidal neurons on hippocampal slices and on proton-induced increase in [Ca2+]i in cerebellar granule cells in cerebellar slices.
  2. 02LabEx vivo tissueMechanism

    In rat cerebellar slices, Semax at 1 μM had no significant effect on the proton-stimulated increase in intracellular calcium in granule cells.

    In plain wordsIn lab tests on rat brain slices, Semax did not change the acid-triggered calcium rise in cerebellar nerve cells.

    Peptide
    Semax
    Outcome
    No significant changeProton-induced intracellular calcium increase, cerebellar granule cells
    Study

    ratn: not reported in source

    cerebellar slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 μMAs given in this study (rat).

    Source sentences

    Summary
    but had no significant effect on proton-stimulated increase in [Ca2+]i in cerebellar granule cells.
    1 context sentence
    Summary · context
    We studied the effects of Semax on spontaneous fluctuations of intracellular calcium ion concentration [Ca2+]i in pyramidal neurons on hippocampal slices and on proton-induced increase in [Ca2+]i in cerebellar granule cells in cerebellar slices.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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