Skip to content

Study · Randomized controlled trial · n = 8 · 2026

3 results

The effect of intranasal oxytocin on theory of mind in children with attention deficit/hyperactive disorder.

Saker T, Blechman S, Dror C, Ravona-Springer R, Ganem H, Tzur Bitan D, Bloch Y, Maoz H

Journal of psychiatric research21 Oct 2025

PMID41138507 (opens in a new tab)DOI10.1016/j.jpsychires.2025.10.031 (opens in a new tab)PepBankPUB-41138507
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In children with ADHD, a single dose of intranasal oxytocin was followed by improvements in mean reaction time in tasks of theory of mind and emotion recognition.

    In plain wordsIn eight children with ADHD, one dose of oxytocin spray was followed by better reaction time in social thinking tasks. Very small study.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedMean reaction time in theory of mind and emotion recognition tasks
    Study

    n = 8

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    Results demonstrated improvements in mean reaction time and response consistency in tasks assessing ToM and emotion recognition following OT administration.
    1 context sentence
    Summary · context
    Eight participants (6 males, 2 females), all diagnosed with ADHD, were randomly assigned to receive a single dose of IN-OT or placebo in a double-blind, crossover design.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In children with ADHD, a single dose of intranasal oxytocin was followed by improvements in response consistency in tasks of theory of mind and emotion recognition.

    In plain wordsIn eight children with ADHD, one dose of oxytocin spray was followed by more consistent answers in social thinking tasks. Very small study.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedResponse consistency in theory of mind and emotion recognition tasks
    Study

    n = 8

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    Results demonstrated improvements in mean reaction time and response consistency in tasks assessing ToM and emotion recognition following OT administration.
    1 context sentence
    Summary · context
    Eight participants (6 males, 2 females), all diagnosed with ADHD, were randomly assigned to receive a single dose of IN-OT or placebo in a double-blind, crossover design.
  3. 03HumanRandomized controlled trialSafety outcome

    No adverse effects were reported in children with ADHD after intranasal oxytocin.

    In plain wordsNo side effects were reported in the eight children given oxytocin spray.

    Peptide
    Oxytocin
    Outcome
    No significant changeAdverse effects
    Study

    n = 8

    Comparator
    Placebo
    Outcome group
    Adverse events · Whole body
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    No adverse effects were reported.
    1 context sentence
    Summary · context
    Eight participants (6 males, 2 females), all diagnosed with ADHD, were randomly assigned to receive a single dose of IN-OT or placebo in a double-blind, crossover design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.