MOTS-C levels ın ındividuals with and without obesity and ıts association with ınflammation, insulin resistance and endothelial dysfunction.

Ozkaya DY, Haymana C, Demirci I, Duman UG, Küpçük E, Koç GE, Tasci I, Sonmez YA

Archives of endocrinology and metabolism26 Sept 2025Cited by 1 (Europe PMC)

PMID41004666PMCIDPMC12468430DOI10.20945/2359-4292-2025-0063PepBankPUB-41004666

Summary

ObjectiveTo investigate the Mitochondrial Open Reading Frame of the 12S rRNA type-c (MOTS-c) peptide levels in individuals with obesity compared to those with a normal body mass index and to examine the association of MOTS-c levels with markers of insulin resistance, endothelial function, and inflammation.MethodsIn this study 85 individuals were enrolled, including 48 with a body mass index ≥ 30 kg/m2 and 37 with a body mass index between 18.5 and 24.9 kg/m2. Individuals with smoking, pregnancy, type 2 diabetes mellitus and other chronic conditions were excluded. Blood samples were collected after at least 8 hours of fasting to measure serum MOTS-c, insulin, high-sensitivity C-reactive protein, and asymmetric dimethylarginine levels. Statistical analyses included t-tests, Mann-Whitney U tests, Chi-squared tests, correlation analyses, and multiple regression analyses.ResultsWe found no significant difference in serum MOTS-c levels between individuals with obesity and those with normal body mass index (14.33 ± 3.76 pg/mL versus 13.67 ± 3.44 pg/mL; p = 0.395). Serum MOTS-c levels showed a significant positive correlation with the HOMA-IR index (p < 0.05) but did not correlate with high-sensitivity C-reactive protein or asymmetric dimethylarginine levels. Multiple regression analysis indicated that age and HOMA-IR were significant predictors of MOTS-c levels, with MOTS-c decreasing with age and increasing with higher insulin resistance.ConclusionSerum MOTS-c levels were similar in individuals with obesity and those with normal weight. The study highlighted age and insulin resistance as significant determinants of MOTS-c levels.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In adults, serum MOTS‑c levels did not differ significantly between individuals with obesity and those with normal body mass index.
In plain wordsIn adults, the body's own MOTS‑c levels were similar in people with obesity and people with normal weight.
Peptide
MOTS-c
Outcome
No significant changeSerum MOTS-c, obesity versus normal BMI
Study
n = 85
Comparator
Normal body mass index
Outcome group
Mitochondrial function · Metabolic and weight
Measurements
serum MOTS-c
14.33 pg/mL
obesity
serum MOTS-c
13.67 pg/mL
normal BMI
Source sentences
Summary
We found no significant difference in serum MOTS-c levels between individuals with obesity and those with normal body mass index (14.33 ± 3.76 pg/mL versus 13.67 ± 3.44 pg/mL; p = 0.395).
1 context sentence(design, population, supporting numbers)
Summary · context
In this study 85 individuals were enrolled, including 48 with a body mass index ≥ 30 kg/m2 and 37 with a body mass index between 18.5 and 24.9 kg/m2.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-4100466601
02HumanEndogenous levelObservational studyOther
In adults with and without obesity, serum MOTS‑c levels correlated positively with the HOMA-IR index.
In plain wordsIn adults, higher body's own MOTS‑c levels were linked to higher insulin resistance.
Peptide
MOTS-c
Outcome
IncreaseCorrelation of serum MOTS-c with HOMA-IR
Study
n = 85
Outcome group
Mitochondrial function · Metabolic and weight
Source sentences
Summary
Serum MOTS-c levels showed a significant positive correlation with the HOMA-IR index (p < 0.05)
1 context sentence(design, population, supporting numbers)
Summary · context
In this study 85 individuals were enrolled, including 48 with a body mass index ≥ 30 kg/m2 and 37 with a body mass index between 18.5 and 24.9 kg/m2.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-4100466602
03HumanEndogenous levelObservational studyOther
In adults with and without obesity, serum MOTS‑c levels did not correlate with high-sensitivity C-reactive protein or asymmetric dimethylarginine.
In plain wordsIn adults, the body's own MOTS‑c levels were not linked to inflammation or endothelial markers.
Peptide
MOTS-c
Outcome
No significant changeCorrelation of serum MOTS-c with hs-CRP and ADMA
Study
n = 85
Outcome group
Inflammation markers · Metabolic and weight
Source sentences
Summary
but did not correlate with high-sensitivity C-reactive protein or asymmetric dimethylarginine levels.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study 85 individuals were enrolled, including 48 with a body mass index ≥ 30 kg/m2 and 37 with a body mass index between 18.5 and 24.9 kg/m2.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-4100466603
04HumanEndogenous levelObservational studyOther
In adults with and without obesity, serum MOTS‑c levels decreased with age in multiple regression.
In plain wordsIn adults, the body's own MOTS‑c levels were lower at older ages.
Peptide
MOTS-c
Outcome
DecreaseAge as predictor of serum MOTS-c
Study
n = 85
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
Multiple regression analysis indicated that age and HOMA-IR were significant predictors of MOTS-c levels, with MOTS-c decreasing with age and increasing with higher insulin resistance.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study 85 individuals were enrolled, including 48 with a body mass index ≥ 30 kg/m2 and 37 with a body mass index between 18.5 and 24.9 kg/m2.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-4100466604
05HumanEndogenous levelObservational studyOther
In adults with and without obesity, serum MOTS‑c levels increased with higher insulin resistance (HOMA-IR) in multiple regression.
In plain wordsIn adults, the body's own MOTS‑c levels were higher when insulin resistance was higher.
Peptide
MOTS-c
Outcome
IncreaseHOMA-IR as predictor of serum MOTS-c
Study
n = 85
Outcome group
Mitochondrial function · Metabolic and weight
Source sentences
Summary
Multiple regression analysis indicated that age and HOMA-IR were significant predictors of MOTS-c levels, with MOTS-c decreasing with age and increasing with higher insulin resistance.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study 85 individuals were enrolled, including 48 with a body mass index ≥ 30 kg/m2 and 37 with a body mass index between 18.5 and 24.9 kg/m2.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-4100466605

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.