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Study · In vitro (cells) · 2025

3 results

The Immunomodulatory Activity of Thymosin Alpha 1 on Tumor Cell Lines and Distinct Immune Cell Subsets.

Solmonese L, Lofiego MF, Fazio C, Marzani F, Piazzini F, Bello E, Celesti F, Giacobini G, Wang X, Maio M, Coral S, Di Giacomo AM, Covre A

OncoTargets and therapy10 Sept 2025

PMID40955371 (opens in a new tab)PMCIDPMC12433645 (opens in a new tab)DOI10.2147/ott.s527785 (opens in a new tab)PepBankPUB-40955371
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In melanoma, glioblastoma and mesothelioma cell lines, Tα1 minimally changed differentially expressed genes and immune-related biological processes.

    In plain wordsIn cancer cells grown in the lab, thymosin alpha‑1 barely changed gene activity or immune-related processes.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeDifferentially expressed genes in cancer cell lines
    Study

    n: not reported in source

    Cutaneous melanoma, glioblastoma and pleural mesothelioma cell lines
    Comparator
    Untreated cells
    Outcome group
    Immune response · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tα1 minimally changed cancer cell DEGs and immune-related biological processes, suggesting a comprehensive lack of transcriptional immunomodulatory potential on the tumor counterpart.
    2 context sentences
    Summary · context
    Cutaneous melanoma, glioblastoma, and pleural mesothelioma cell lines and HD immune cell subsets were treated with Tα1 for 48 hours.
    Summary · context
    Total RNA was subsequently isolated, and gene expression profiles were analyzed by the nCounter® SPRINT Profiler.
  2. 02LabIn vitro (cells)Mechanism

    In immune cell subsets from healthy donors, Tα1 directly affected proliferation and/or transcription in each subset.

    In plain wordsIn immune cells from healthy donors grown in the lab, thymosin alpha‑1 changed growth or gene activity in every cell type studied.

    Peptide
    Thymosin alpha-1
    Outcome
    MixedProliferation and transcription of immune cell subsets
    Study

    humann: not reported in source

    CD4+ T, CD8+ T, B and NK cells from healthy donors
    Comparator
    Untreated cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Conversely, Tα1 exhibited to directly affect the proliferation and/or transcription processes of each studied immune cell subset, with the greatest transcriptional impact observed for activated CD8+ T cells, crucial players in anti-tumor immunity.
    2 context sentences
    Summary · context
    Cutaneous melanoma, glioblastoma, and pleural mesothelioma cell lines and HD immune cell subsets were treated with Tα1 for 48 hours.
    Summary · context
    Total RNA was subsequently isolated, and gene expression profiles were analyzed by the nCounter® SPRINT Profiler.
  3. 03LabIn vitro (cells)Mechanism

    Among immune cell subsets from healthy donors, activated CD8+ T cells showed the greatest transcriptional impact of Tα1.

    In plain wordsIn lab tests, thymosin alpha‑1 changed gene activity most in activated CD8 T cells among the immune cells studied.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableTranscriptional impact on activated CD8+ T cells
    Study

    humann: not reported in source

    Activated CD8+ T cells from healthy donors
    Comparator
    Untreated cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    with the greatest transcriptional impact observed for activated CD8+ T cells, crucial players in anti-tumor immunity.
    2 context sentences
    Summary · context
    Cutaneous melanoma, glioblastoma, and pleural mesothelioma cell lines and HD immune cell subsets were treated with Tα1 for 48 hours.
    Summary · context
    Total RNA was subsequently isolated, and gene expression profiles were analyzed by the nCounter® SPRINT Profiler.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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